PALM2-AKAP2
Q9Y2D5 PLAK2_HUMANStats by Source
Total, split by cell line (COSMIC CL / DepMap / PubMed) vs tissue (COSMIC primary tissue)
Total = all mutations for this gene across every source.
Cell line = COSMIC Cell Lines Project + DepMap + PubMed.
Tissue = COSMIC primary-tissue (patient tumour) samples.
Total can exceed cell line + tissue: COSMIC tissue-derived models sit only in global, and a peptide can be shared across both.
| Total | Cell line | Tissue | |
|---|---|---|---|
| Mutations | 1,129 | 109 | 1,014 |
| Samples | 525 | 51 | 471 |
| Peptides | 422 | 49 | 379 |
Isoforms & Proteins
2 transcripts · UniProt mapping is sequence-verified (AA-safe)
Each Ensembl transcript (ENST) this gene is mutated on, with its matched UniProt accession.
The mapping is sequence-verified: the UniProt sequence is identical to the transcript translation, so amino-acid positions line up exactly. A * marks an unreviewed (TrEMBL) entry.
Counts are mutations and unique mutant peptides on each transcript.
Recurrent Mutations
All 414 amino-acid changes on canonical ENST00000374530 · needle height = samples · drag the mini-map to zoom
A lollipop / needle plot – the standard way to show recurrent mutations along a protein (as used by cBioPortal and MutationMapper).
X-axis = amino-acid position in the protein.
Needle height & head size = how often that exact amino-acid change was observed (its recurrence). Tall/large heads are mutational hotspots.
The most recurrent changes are labelled; hover any needle for the change, position and counts.
Mutation frequency across cancer types
% of samples with a missense/complex mutation in PALM2-AKAP2 · cell line vs tissue
For each cancer type, the fraction of samples that carry at least one missense/complex mutation anywhere in PALM2-AKAP2 – counted as distinct samples (a sample counts once no matter how many mutations it has).
Split into cell line and tissue; each cell shows mutated / total and the percentage. Cohorts with <20 samples are omitted. Ordered by combined frequency.
| Cancer type | Cell lines | Tissue samples |
|---|---|---|
| Endometrial Carcinoma | 3/42 7% | 30/612 5% |
| T-Lymphoblastic Leukemia | 2/40 5% | 0/0 0% |
| Gastrointestinal Stromal Tumour | 0/0 0% | 4/133 3% |
| Melanoma | 6/210 3% | 48/1899 3% |
| Acute Myeloid Leukemia | 2/90 2% | 0/0 0% |
| Glioblastoma | 2/98 2% | 0/0 0% |
| Gastric Carcinoma | 2/74 3% | 36/1809 2% |
| Other Solid Cancers | 0/94 0% | 32/1515 2% |
| Squamous Cell Lung Carcinoma | 1/57 2% | 16/810 2% |
| Non-Small Cell Lung Carcinoma | 5/304 2% | 27/1390 2% |
| Oral Cavity Carcinoma | 1/54 2% | 0/0 0% |
| Bladder Carcinoma | 1/58 2% | 17/956 2% |
| Cervical Carcinoma | 0/35 0% | 8/422 2% |
| Ovarian Carcinoma | 3/109 3% | 15/998 2% |
| Head and Neck Carcinoma | 2/85 2% | 24/1574 2% |
| Colorectal Carcinoma | 8/143 6% | 45/3239 1% |
| Germ Cell Tumour | 0/25 0% | 3/169 2% |
| Glioma | 0/52 0% | 31/2127 1% |
| Chondrosarcoma | 0/14 0% | 1/75 1% |
| Esophageal Carcinoma | 0/23 0% | 8/769 1% |
| Esophageal Squamous Cell Carcinoma | 1/51 2% | 25/2550 1% |
| Biliary Tract Carcinoma | 0/54 0% | 9/950 1% |
| Burkitts Lymphoma | 0/32 0% | 2/196 1% |
| Hodgkins Lymphoma | 0/16 0% | 1/122 1% |
| Neuroendocrine Tumour | 3/154 2% | 2/577 0% |
| Hepatocellular Carcinoma | 1/46 2% | 14/2210 1% |
| Other Sarcomas | 0/69 0% | 5/699 1% |
| Ewings Sarcoma | 0/63 0% | 2/262 1% |
| Thyroid Gland Carcinoma | 1/45 2% | 8/1592 0% |
| Breast Carcinoma | 3/144 2% | 15/3264 0% |
Mutation Distribution
Where PALM2-AKAP2 is mutated · all tissues, split by cell line vs tissue
How many mutations in PALM2-AKAP2 were found in each tissue, across the whole database.
Each bar is a tissue (cell-line and tissue names are merged to the standard tissue), split into cell line and tissue (patient tumour) contributions.
This shows the cancer-context where this gene is recurrently altered.
Mutations
All 1,129 mutations in PALM2-AKAP2
Every mutation record for this gene, across all samples and sources.
The Sample column links to the cell line (cell-line samples) or the tissue type (tissue samples).
Use the Type / Source filters, the search box, and column sorting to explore; each CAN-IMMUNE ID opens the full mutation & peptide view.
| ID | Sample | Transcript | AA Change | CDS | Type | Source | Mutant Peptide | Wild-type Peptide |
|---|