Stats by Source
Total, split by cell line (COSMIC CL / DepMap / PubMed) vs tissue (COSMIC primary tissue)
Total = all mutations for this gene across every source.
Cell line = COSMIC Cell Lines Project + DepMap + PubMed.
Tissue = COSMIC primary-tissue (patient tumour) samples.
Total can exceed cell line + tissue: COSMIC tissue-derived models sit only in global, and a peptide can be shared across both.
| Total | Cell line | Tissue | |
|---|---|---|---|
| Mutations | 3,441 | 452 | 2,937 |
| Samples | 1,963 | 321 | 1,606 |
| Peptides | 1,507 | 228 | 1,336 |
Function
PAPPA2 · Pappalysin 2
This gene encodes a member of the pappalysin family of metzincin metalloproteinases. The encoded protein cleaves insulin-like growth factor-binding protein 5 and is thought to be a local regulator of insulin-like growth factor (IGF) bioavailability. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2010].
Isoforms & Proteins
2 transcripts · UniProt mapping is sequence-verified (AA-safe)
Each Ensembl transcript (ENST) this gene is mutated on, with its matched UniProt accession.
The mapping is sequence-verified: the UniProt sequence is identical to the transcript translation, so amino-acid positions line up exactly. A * marks an unreviewed (TrEMBL) entry.
Counts are mutations and unique mutant peptides on each transcript.
Gene Properties
Recurrent Mutations
All 1488 amino-acid changes on canonical ENST00000367662 · needle height = samples · drag the mini-map to zoom
A lollipop / needle plot – the standard way to show recurrent mutations along a protein (as used by cBioPortal and MutationMapper).
X-axis = amino-acid position in the protein.
Needle height & head size = how often that exact amino-acid change was observed (its recurrence). Tall/large heads are mutational hotspots.
The most recurrent changes are labelled; hover any needle for the change, position and counts.
Mutation frequency across cancer types
% of samples with a missense/complex mutation in PAPPA2 · cell line vs tissue
For each cancer type, the fraction of samples that carry at least one missense/complex mutation anywhere in PAPPA2 – counted as distinct samples (a sample counts once no matter how many mutations it has).
Split into cell line and tissue; each cell shows mutated / total and the percentage. Cohorts with <20 samples are omitted. Ordered by combined frequency.
| Cancer type | Cell lines | Tissue samples |
|---|---|---|
| Chronic Myelogenous Leukemia | 5/25 20% | 0/0 0% |
| Melanoma | 34/210 16% | 294/1899 15% |
| Non-Small Cell Lung Carcinoma | 45/304 15% | 186/1390 13% |
| Squamous Cell Lung Carcinoma | 11/57 19% | 98/810 12% |
| T-Cell Non-Hodgkins Lymphoma | 3/26 12% | 0/0 0% |
| T-Lymphoblastic Leukemia | 4/40 10% | 0/0 0% |
| Endometrial Carcinoma | 10/42 24% | 55/612 9% |
| Oral Cavity Carcinoma | 5/54 9% | 0/0 0% |
| Other Solid Cancers | 5/94 5% | 143/1515 9% |
| Small Cell Lung Carcinoma | 1/9 11% | 51/752 7% |
| Acute Myeloid Leukemia | 6/90 7% | 0/0 0% |
| Colorectal Carcinoma | 37/143 26% | 187/3239 6% |
| Gastric Carcinoma | 6/74 8% | 114/1809 6% |
| Neuroendocrine Tumour | 27/154 18% | 14/577 2% |
| Glioblastoma | 5/98 5% | 0/0 0% |
| Chordoma | 1/7 14% | 0/13 0% |
| Head and Neck Carcinoma | 7/85 8% | 71/1574 5% |
| Hodgkins Lymphoma | 4/16 25% | 2/122 2% |
| Rhabdomyosarcoma | 5/33 15% | 3/171 2% |
| Acute Monocytic Leukemia | 0/1 0% | 1/25 4% |
| Bladder Carcinoma | 10/58 17% | 26/956 3% |
| Cervical Carcinoma | 4/35 11% | 12/422 3% |
| Other Sarcomas | 9/69 13% | 17/699 2% |
| Esophageal Squamous Cell Carcinoma | 7/51 14% | 70/2550 3% |
| Esophageal Carcinoma | 2/23 9% | 19/769 2% |
| Ovarian Carcinoma | 15/109 14% | 13/998 1% |
| Biliary Tract Carcinoma | 1/54 2% | 24/950 3% |
| Germ Cell Tumour | 3/25 12% | 1/169 1% |
| Breast Carcinoma | 8/144 6% | 51/3264 2% |
| Pancreatic Carcinoma | 4/89 4% | 21/1611 1% |
Mutation Distribution
Where PAPPA2 is mutated · all tissues, split by cell line vs tissue
How many mutations in PAPPA2 were found in each tissue, across the whole database.
Each bar is a tissue (cell-line and tissue names are merged to the standard tissue), split into cell line and tissue (patient tumour) contributions.
This shows the cancer-context where this gene is recurrently altered.
GTEx Expression
Median TPM across 54 healthy tissues
Median gene expression (TPM) in normal, non-cancer human tissues from the GTEx project.
Useful for judging tumour specificity – a strong neoantigen target ideally comes from a gene with low expression in healthy tissues.
Scroll or drag the mini-axis below the chart to browse all tissues.
Mutations
All 3,441 mutations in PAPPA2
Every mutation record for this gene, across all samples and sources.
The Sample column links to the cell line (cell-line samples) or the tissue type (tissue samples).
Use the Type / Source filters, the search box, and column sorting to explore; each CAN-IMMUNE ID opens the full mutation & peptide view.
| ID | Sample | Transcript | AA Change | CDS | Type | Source | Mutant Peptide | Wild-type Peptide |
|---|