Stats by Source
Total, split by cell line (COSMIC CL / DepMap / PubMed) vs tissue (COSMIC primary tissue)
Total = all mutations for this gene across every source.
Cell line = COSMIC Cell Lines Project + DepMap + PubMed.
Tissue = COSMIC primary-tissue (patient tumour) samples.
Total can exceed cell line + tissue: COSMIC tissue-derived models sit only in global, and a peptide can be shared across both.
| Total | Cell line | Tissue | |
|---|---|---|---|
| Mutations | 1,155 | 152 | 992 |
| Samples | 873 | 129 | 737 |
| Peptides | 552 | 92 | 462 |
Function
PARP4 · Poly(ADP-ribose) polymerase family member 4
This gene encodes poly(ADP-ribosyl)transferase-like 1 protein, which is capable of catalyzing a poly(ADP-ribosyl)ation reaction. This protein has a catalytic domain which is homologous to that of poly (ADP-ribosyl) transferase, but lacks an N-terminal DNA binding domain which activates the C-terminal catalytic domain of poly (ADP-ribosyl) transferase. Since this protein is not capable of binding DNA directly, its transferase activity may be activated by other factors such as protein-protein interaction mediated by the extensive carboxyl terminus. [provided by RefSeq, Jul 2008].
Isoforms & Proteins
1 transcript · UniProt mapping is sequence-verified (AA-safe)
Each Ensembl transcript (ENST) this gene is mutated on, with its matched UniProt accession.
The mapping is sequence-verified: the UniProt sequence is identical to the transcript translation, so amino-acid positions line up exactly. A * marks an unreviewed (TrEMBL) entry.
Counts are mutations and unique mutant peptides on each transcript.
| Transcript | UniProt | Mutations | Peptides |
|---|---|---|---|
| ENST00000381989 | Q9UKK3 | 1,155 | 552 |
Gene Properties
Recurrent Mutations
All 552 amino-acid changes on canonical ENST00000381989 · needle height = samples · drag the mini-map to zoom
A lollipop / needle plot – the standard way to show recurrent mutations along a protein (as used by cBioPortal and MutationMapper).
X-axis = amino-acid position in the protein.
Needle height & head size = how often that exact amino-acid change was observed (its recurrence). Tall/large heads are mutational hotspots.
The most recurrent changes are labelled; hover any needle for the change, position and counts.
Mutation frequency across cancer types
% of samples with a missense/complex mutation in PARP4 · cell line vs tissue
For each cancer type, the fraction of samples that carry at least one missense/complex mutation anywhere in PARP4 – counted as distinct samples (a sample counts once no matter how many mutations it has).
Split into cell line and tissue; each cell shows mutated / total and the percentage. Cohorts with <20 samples are omitted. Ordered by combined frequency.
| Cancer type | Cell lines | Tissue samples |
|---|---|---|
| T-Lymphoblastic Leukemia | 4/40 10% | 0/0 0% |
| T-Cell Non-Hodgkins Lymphoma | 2/26 8% | 0/0 0% |
| Gastrointestinal Stromal Tumour | 0/0 0% | 8/133 6% |
| Non-Small Cell Lung Carcinoma | 29/304 10% | 68/1390 5% |
| Oral Cavity Carcinoma | 3/54 6% | 0/0 0% |
| Endometrial Carcinoma | 10/42 24% | 24/612 4% |
| Melanoma | 11/210 5% | 84/1899 4% |
| Chronic Myelogenous Leukemia | 1/25 4% | 0/0 0% |
| Bladder Carcinoma | 1/58 2% | 37/956 4% |
| Thyroid Gland Carcinoma | 2/45 4% | 48/1592 3% |
| Colorectal Carcinoma | 13/143 9% | 85/3239 3% |
| Other Solid Cancers | 1/94 1% | 45/1515 3% |
| Squamous Cell Lung Carcinoma | 7/57 12% | 16/810 2% |
| Gastric Carcinoma | 5/74 7% | 35/1809 2% |
| Neuroendocrine Tumour | 3/154 2% | 10/577 2% |
| Burkitts Lymphoma | 2/32 6% | 2/196 1% |
| Cervical Carcinoma | 0/35 0% | 7/422 2% |
| Esophageal Carcinoma | 2/23 9% | 10/769 1% |
| Other Blood Cancers | 1/61 2% | 39/2725 1% |
| Pheochromocytoma and Paraganglioma | 0/0 0% | 1/71 1% |
| Biliary Tract Carcinoma | 1/54 2% | 13/950 1% |
| Hepatocellular Carcinoma | 2/46 4% | 29/2210 1% |
| Ovarian Carcinoma | 3/109 3% | 12/998 1% |
| Ewings Sarcoma | 3/63 5% | 1/262 0% |
| Glioma | 2/52 4% | 23/2127 1% |
| Acute Myeloid Leukemia | 1/90 1% | 0/0 0% |
| Small Cell Lung Carcinoma | 0/9 0% | 8/752 1% |
| Germ Cell Tumour | 1/25 4% | 1/169 1% |
| Glioblastoma | 1/98 1% | 0/0 0% |
| Breast Carcinoma | 0/144 0% | 33/3264 1% |
Mutation Distribution
Where PARP4 is mutated · all tissues, split by cell line vs tissue
How many mutations in PARP4 were found in each tissue, across the whole database.
Each bar is a tissue (cell-line and tissue names are merged to the standard tissue), split into cell line and tissue (patient tumour) contributions.
This shows the cancer-context where this gene is recurrently altered.
GTEx Expression
Median TPM across 54 healthy tissues
Median gene expression (TPM) in normal, non-cancer human tissues from the GTEx project.
Useful for judging tumour specificity – a strong neoantigen target ideally comes from a gene with low expression in healthy tissues.
Scroll or drag the mini-axis below the chart to browse all tissues.
Mutations
All 1,155 mutations in PARP4
Every mutation record for this gene, across all samples and sources.
The Sample column links to the cell line (cell-line samples) or the tissue type (tissue samples).
Use the Type / Source filters, the search box, and column sorting to explore; each CAN-IMMUNE ID opens the full mutation & peptide view.
| ID | Sample | Transcript | AA Change | CDS | Type | Source | Mutant Peptide | Wild-type Peptide |
|---|