Stats by Source
Total, split by cell line (COSMIC CL / DepMap / PubMed) vs tissue (COSMIC primary tissue)
Total = all mutations for this gene across every source.
Cell line = COSMIC Cell Lines Project + DepMap + PubMed.
Tissue = COSMIC primary-tissue (patient tumour) samples.
Total can exceed cell line + tissue: COSMIC tissue-derived models sit only in global, and a peptide can be shared across both.
| Total | Cell line | Tissue | |
|---|---|---|---|
| Mutations | 1,769 | 257 | 1,501 |
| Samples | 624 | 126 | 494 |
| Peptides | 493 | 77 | 425 |
Function
PDE11A · Phosphodiesterase 11A
The 3',5'-cyclic nucleotides cAMP and cGMP function as second messengers in a wide variety of signal transduction pathways. 3',5'-cyclic nucleotide phosphodiesterases (PDEs) catalyze the hydrolysis of cAMP and cGMP to the corresponding 5'-monophosphates and provide a mechanism to downregulate cAMP and cGMP signaling. This gene encodes a member of the PDE protein superfamily. Mutations in this gene are a cause of Cushing disease and adrenocortical hyperplasia. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008].
Isoforms & Proteins
4 transcripts · UniProt mapping is sequence-verified (AA-safe)
Each Ensembl transcript (ENST) this gene is mutated on, with its matched UniProt accession.
The mapping is sequence-verified: the UniProt sequence is identical to the transcript translation, so amino-acid positions line up exactly. A * marks an unreviewed (TrEMBL) entry.
Counts are mutations and unique mutant peptides on each transcript.
Gene Properties
Recurrent Mutations
All 453 amino-acid changes on canonical ENST00000286063 · needle height = samples · drag the mini-map to zoom
A lollipop / needle plot – the standard way to show recurrent mutations along a protein (as used by cBioPortal and MutationMapper).
X-axis = amino-acid position in the protein.
Needle height & head size = how often that exact amino-acid change was observed (its recurrence). Tall/large heads are mutational hotspots.
The most recurrent changes are labelled; hover any needle for the change, position and counts.
Mutation frequency across cancer types
% of samples with a missense/complex mutation in PDE11A · cell line vs tissue
For each cancer type, the fraction of samples that carry at least one missense/complex mutation anywhere in PDE11A – counted as distinct samples (a sample counts once no matter how many mutations it has).
Split into cell line and tissue; each cell shows mutated / total and the percentage. Cohorts with <20 samples are omitted. Ordered by combined frequency.
| Cancer type | Cell lines | Tissue samples |
|---|---|---|
| Oral Cavity Carcinoma | 3/54 6% | 0/0 0% |
| T-Lymphoblastic Leukemia | 2/40 5% | 0/0 0% |
| Gastrointestinal Stromal Tumour | 0/0 0% | 6/133 5% |
| Squamous Cell Lung Carcinoma | 8/57 14% | 29/810 4% |
| Endometrial Carcinoma | 5/42 12% | 22/612 4% |
| Chronic Myelogenous Leukemia | 1/25 4% | 0/0 0% |
| Melanoma | 12/210 6% | 66/1899 3% |
| Rhabdomyosarcoma | 6/33 18% | 0/171 0% |
| Non-Small Cell Lung Carcinoma | 13/304 4% | 34/1390 2% |
| Neuroendocrine Tumour | 13/154 8% | 6/577 1% |
| Colorectal Carcinoma | 18/143 13% | 69/3239 2% |
| Bladder Carcinoma | 2/58 3% | 21/956 2% |
| Other Solid Cancers | 2/94 2% | 34/1515 2% |
| Gastric Carcinoma | 5/74 7% | 29/1809 2% |
| Esophageal Squamous Cell Carcinoma | 2/51 4% | 43/2550 2% |
| Ovarian Carcinoma | 7/109 6% | 12/998 1% |
| Pheochromocytoma and Paraganglioma | 0/0 0% | 1/71 1% |
| Cervical Carcinoma | 0/35 0% | 6/422 1% |
| Small Cell Lung Carcinoma | 2/9 22% | 7/752 1% |
| Acute Myeloid Leukemia | 1/90 1% | 0/0 0% |
| Other Sarcomas | 3/69 4% | 5/699 1% |
| Osteosarcoma | 2/45 4% | 0/166 0% |
| Head and Neck Carcinoma | 3/85 4% | 12/1574 1% |
| Non-Cancerous | 0/104 0% | 8/830 1% |
| Plasma Cell Myeloma | 0/44 0% | 3/305 1% |
| Biliary Tract Carcinoma | 1/54 2% | 7/950 1% |
| Medulloblastoma | 0/0 0% | 3/450 1% |
| Breast Carcinoma | 5/144 3% | 17/3264 1% |
| Glioma | 1/52 2% | 11/2127 1% |
| Germ Cell Tumour | 1/25 4% | 0/169 0% |
Mutation Distribution
Where PDE11A is mutated · all tissues, split by cell line vs tissue
How many mutations in PDE11A were found in each tissue, across the whole database.
Each bar is a tissue (cell-line and tissue names are merged to the standard tissue), split into cell line and tissue (patient tumour) contributions.
This shows the cancer-context where this gene is recurrently altered.
GTEx Expression
Median TPM across 53 healthy tissues
Median gene expression (TPM) in normal, non-cancer human tissues from the GTEx project.
Useful for judging tumour specificity – a strong neoantigen target ideally comes from a gene with low expression in healthy tissues.
Scroll or drag the mini-axis below the chart to browse all tissues.
Mutations
All 1,769 mutations in PDE11A
Every mutation record for this gene, across all samples and sources.
The Sample column links to the cell line (cell-line samples) or the tissue type (tissue samples).
Use the Type / Source filters, the search box, and column sorting to explore; each CAN-IMMUNE ID opens the full mutation & peptide view.
| ID | Sample | Transcript | AA Change | CDS | Type | Source | Mutant Peptide | Wild-type Peptide |
|---|