Stats by Source
Total, split by cell line (COSMIC CL / DepMap / PubMed) vs tissue (COSMIC primary tissue)
Total = all mutations for this gene across every source.
Cell line = COSMIC Cell Lines Project + DepMap + PubMed.
Tissue = COSMIC primary-tissue (patient tumour) samples.
Total can exceed cell line + tissue: COSMIC tissue-derived models sit only in global, and a peptide can be shared across both.
| Total | Cell line | Tissue | |
|---|---|---|---|
| Mutations | 2,071 | 264 | 1,797 |
| Samples | 505 | 87 | 408 |
| Peptides | 383 | 69 | 321 |
Function
PDE4A · Phosphodiesterase 4A
The protein encoded by this gene belongs to the cyclic nucleotide phosphodiesterase (PDE) family, and PDE4 subfamily. This PDE hydrolyzes the second messenger, cAMP, which is a regulator and mediator of a number of cellular responses to extracellular signals. Thus, by regulating the cellular concentration of cAMP, this protein plays a key role in many important physiological processes. Alternatively spliced transcript variants encoding different isoforms have been described for this gene.[provided by RefSeq, Jul 2011].
Isoforms & Proteins
5 transcripts · UniProt mapping is sequence-verified (AA-safe)
Each Ensembl transcript (ENST) this gene is mutated on, with its matched UniProt accession.
The mapping is sequence-verified: the UniProt sequence is identical to the transcript translation, so amino-acid positions line up exactly. A * marks an unreviewed (TrEMBL) entry.
Counts are mutations and unique mutant peptides on each transcript.
Gene Properties
Recurrent Mutations
All 328 amino-acid changes on canonical ENST00000380702 · needle height = samples · drag the mini-map to zoom
A lollipop / needle plot – the standard way to show recurrent mutations along a protein (as used by cBioPortal and MutationMapper).
X-axis = amino-acid position in the protein.
Needle height & head size = how often that exact amino-acid change was observed (its recurrence). Tall/large heads are mutational hotspots.
The most recurrent changes are labelled; hover any needle for the change, position and counts.
Mutation frequency across cancer types
% of samples with a missense/complex mutation in PDE4A · cell line vs tissue
For each cancer type, the fraction of samples that carry at least one missense/complex mutation anywhere in PDE4A – counted as distinct samples (a sample counts once no matter how many mutations it has).
Split into cell line and tissue; each cell shows mutated / total and the percentage. Cohorts with <20 samples are omitted. Ordered by combined frequency.
| Cancer type | Cell lines | Tissue samples |
|---|---|---|
| T-Lymphoblastic Leukemia | 11/40 28% | 0/0 0% |
| Chronic Myelogenous Leukemia | 3/25 12% | 0/0 0% |
| Melanoma | 8/210 4% | 66/1899 3% |
| Rhabdomyosarcoma | 0/33 0% | 7/171 4% |
| Gastrointestinal Stromal Tumour | 0/0 0% | 4/133 3% |
| Unknown | 0/10 0% | 1/29 3% |
| Other Solid Cancers | 7/94 7% | 30/1515 2% |
| Endometrial Carcinoma | 3/42 7% | 12/612 2% |
| Chondrosarcoma | 2/14 14% | 0/75 0% |
| Colorectal Carcinoma | 15/143 10% | 59/3239 2% |
| Bladder Carcinoma | 1/58 2% | 20/956 2% |
| Gastric Carcinoma | 2/74 3% | 32/1809 2% |
| Non-Cancerous | 0/104 0% | 15/830 2% |
| Ovarian Carcinoma | 1/109 1% | 15/998 2% |
| Thyroid Gland Carcinoma | 2/45 4% | 18/1592 1% |
| Non-Small Cell Lung Carcinoma | 9/304 3% | 11/1390 1% |
| Medulloblastoma | 0/0 0% | 5/450 1% |
| Cervical Carcinoma | 0/35 0% | 5/422 1% |
| Other Sarcomas | 2/69 3% | 6/699 1% |
| Ewings Sarcoma | 0/63 0% | 3/262 1% |
| Burkitts Lymphoma | 2/32 6% | 0/196 0% |
| Squamous Cell Lung Carcinoma | 0/57 0% | 7/810 1% |
| Hepatocellular Carcinoma | 2/46 4% | 16/2210 1% |
| Esophageal Carcinoma | 0/23 0% | 6/769 1% |
| Small Cell Lung Carcinoma | 0/9 0% | 5/752 1% |
| Esophageal Squamous Cell Carcinoma | 1/51 2% | 16/2550 1% |
| Head and Neck Carcinoma | 2/85 2% | 8/1574 1% |
| Neuroendocrine Tumour | 3/154 2% | 1/577 0% |
| Prostate Carcinoma | 3/13 23% | 8/2105 0% |
| Glioma | 0/52 0% | 11/2127 1% |
Mutation Distribution
Where PDE4A is mutated · all tissues, split by cell line vs tissue
How many mutations in PDE4A were found in each tissue, across the whole database.
Each bar is a tissue (cell-line and tissue names are merged to the standard tissue), split into cell line and tissue (patient tumour) contributions.
This shows the cancer-context where this gene is recurrently altered.
GTEx Expression
Median TPM across 54 healthy tissues
Median gene expression (TPM) in normal, non-cancer human tissues from the GTEx project.
Useful for judging tumour specificity – a strong neoantigen target ideally comes from a gene with low expression in healthy tissues.
Scroll or drag the mini-axis below the chart to browse all tissues.
Mutations
All 2,071 mutations in PDE4A
Every mutation record for this gene, across all samples and sources.
The Sample column links to the cell line (cell-line samples) or the tissue type (tissue samples).
Use the Type / Source filters, the search box, and column sorting to explore; each CAN-IMMUNE ID opens the full mutation & peptide view.
| ID | Sample | Transcript | AA Change | CDS | Type | Source | Mutant Peptide | Wild-type Peptide |
|---|