Stats by Source
Total, split by cell line (COSMIC CL / DepMap / PubMed) vs tissue (COSMIC primary tissue)
Total = all mutations for this gene across every source.
Cell line = COSMIC Cell Lines Project + DepMap + PubMed.
Tissue = COSMIC primary-tissue (patient tumour) samples.
Total can exceed cell line + tissue: COSMIC tissue-derived models sit only in global, and a peptide can be shared across both.
| Total | Cell line | Tissue | |
|---|---|---|---|
| Mutations | 2,098 | 239 | 1,812 |
| Samples | 369 | 68 | 291 |
| Peptides | 347 | 56 | 285 |
Function
PDLIM5 · PDZ and LIM domain 5
This gene encodes a member of a family of proteins that possess a 100-amino acid PDZ domain at the N terminus and one to three LIM domains at the C-terminus. This family member functions as a scaffold protein that tethers protein kinases to the Z-disk in striated muscles. It is thought to function in cardiomyocyte expansion and in restraining postsynaptic growth of excitatory synapses. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Jan 2012].
Isoforms & Proteins
12 transcripts · UniProt mapping is sequence-verified (AA-safe)
Each Ensembl transcript (ENST) this gene is mutated on, with its matched UniProt accession.
The mapping is sequence-verified: the UniProt sequence is identical to the transcript translation, so amino-acid positions line up exactly. A * marks an unreviewed (TrEMBL) entry.
Counts are mutations and unique mutant peptides on each transcript.
| Transcript | UniProt | Mutations | Peptides |
|---|---|---|---|
| ENST00000317968 | Q96HC4 | 371 | 246 |
| ENST00000514743 | Q96HC4-6 | 281 | 189 |
| ENST00000615540 | Q96HC4-6 | 281 | 189 |
| ENST00000503974 | Q96HC4-7 | 275 | 184 |
| ENST00000542407 | Q96HC4-4 | 268 | 180 |
| ENST00000437932 | A0A0A0MSP3* | 156 | 93 |
| ENST00000380180 | Q96HC4-2 | 132 | 103 |
| ENST00000508216 | Q96HC4-2 | 132 | 103 |
| ENST00000318007 | Q96HC4-3 | 120 | 94 |
| ENST00000359265 | Q96HC4-5 | 39 | 27 |
| ENST00000512274 | D6RGG6* | 23 | 18 |
| ENST00000504489 | D6RAA1* | 20 | 15 |
Gene Properties
Recurrent Mutations
All 246 amino-acid changes on canonical ENST00000317968 · needle height = samples · drag the mini-map to zoom
A lollipop / needle plot – the standard way to show recurrent mutations along a protein (as used by cBioPortal and MutationMapper).
X-axis = amino-acid position in the protein.
Needle height & head size = how often that exact amino-acid change was observed (its recurrence). Tall/large heads are mutational hotspots.
The most recurrent changes are labelled; hover any needle for the change, position and counts.
Mutation frequency across cancer types
% of samples with a missense/complex mutation in PDLIM5 · cell line vs tissue
For each cancer type, the fraction of samples that carry at least one missense/complex mutation anywhere in PDLIM5 – counted as distinct samples (a sample counts once no matter how many mutations it has).
Split into cell line and tissue; each cell shows mutated / total and the percentage. Cohorts with <20 samples are omitted. Ordered by combined frequency.
| Cancer type | Cell lines | Tissue samples |
|---|---|---|
| Gastrointestinal Stromal Tumour | 0/0 0% | 6/133 5% |
| T-Lymphoblastic Leukemia | 1/40 2% | 0/0 0% |
| Endometrial Carcinoma | 1/42 2% | 15/612 2% |
| Acute Myeloid Leukemia | 2/90 2% | 0/0 0% |
| Melanoma | 0/210 0% | 43/1899 2% |
| Non-Small Cell Lung Carcinoma | 13/304 4% | 20/1390 1% |
| Squamous Cell Lung Carcinoma | 3/57 5% | 13/810 2% |
| Germ Cell Tumour | 2/25 8% | 1/169 1% |
| Colorectal Carcinoma | 12/143 8% | 36/3239 1% |
| Neuroendocrine Tumour | 6/154 4% | 4/577 1% |
| Burkitts Lymphoma | 3/32 9% | 0/196 0% |
| Cervical Carcinoma | 0/35 0% | 6/422 1% |
| Gastric Carcinoma | 2/74 3% | 22/1809 1% |
| Other Sarcomas | 1/69 1% | 8/699 1% |
| Rhabdomyosarcoma | 1/33 3% | 1/171 1% |
| Small Cell Lung Carcinoma | 0/9 0% | 7/752 1% |
| Other Solid Cancers | 2/94 2% | 12/1515 1% |
| Bladder Carcinoma | 0/58 0% | 7/956 1% |
| Non-Cancerous | 0/104 0% | 6/830 1% |
| Esophageal Carcinoma | 0/23 0% | 5/769 1% |
| Hepatocellular Carcinoma | 0/46 0% | 13/2210 1% |
| Thyroid Gland Carcinoma | 0/45 0% | 8/1592 0% |
| Head and Neck Carcinoma | 2/85 2% | 6/1574 0% |
| Glioma | 0/52 0% | 10/2127 0% |
| Medulloblastoma | 0/0 0% | 2/450 0% |
| Pancreatic Carcinoma | 0/89 0% | 7/1611 0% |
| Biliary Tract Carcinoma | 0/54 0% | 4/950 0% |
| Meningioma | 0/3 0% | 1/252 0% |
| Prostate Carcinoma | 0/13 0% | 8/2105 0% |
| Breast Carcinoma | 6/144 4% | 7/3264 0% |
Mutation Distribution
Where PDLIM5 is mutated · all tissues, split by cell line vs tissue
How many mutations in PDLIM5 were found in each tissue, across the whole database.
Each bar is a tissue (cell-line and tissue names are merged to the standard tissue), split into cell line and tissue (patient tumour) contributions.
This shows the cancer-context where this gene is recurrently altered.
GTEx Expression
Median TPM across 54 healthy tissues
Median gene expression (TPM) in normal, non-cancer human tissues from the GTEx project.
Useful for judging tumour specificity – a strong neoantigen target ideally comes from a gene with low expression in healthy tissues.
Scroll or drag the mini-axis below the chart to browse all tissues.
Mutations
All 2,098 mutations in PDLIM5
Every mutation record for this gene, across all samples and sources.
The Sample column links to the cell line (cell-line samples) or the tissue type (tissue samples).
Use the Type / Source filters, the search box, and column sorting to explore; each CAN-IMMUNE ID opens the full mutation & peptide view.
| ID | Sample | Transcript | AA Change | CDS | Type | Source | Mutant Peptide | Wild-type Peptide |
|---|