PIGN Phosphatidylinositol glycan anchor biosynthesis class N O95427 PIGN_HUMAN
Protein Coding Chr 18 18q21.33 Swiss-Prot reviewed Entrez 23556
Mutations
6,265
CL 904 · Tissue 5,146
Samples
329
CL 84 · Tissue 237
Peptides
294
unique mutant peptides
Transcripts
27
isoforms mutated

Stats by Source

Global, split by cell line (COSMIC CL / DepMap / PubMed) vs tissue (COSMIC primary tissue)

How the counts split by source
Stats by Source

Global = all mutations for this gene across every source.

Cell line = COSMIC Cell Lines Project + DepMap + PubMed.

Tissue = COSMIC primary-tissue (patient tumour) samples.

Global can exceed cell line + tissue: COSMIC tissue-derived models sit only in global, and a peptide can be shared across both.

GlobalCell lineTissue
Mutations6,2659045,146
Samples32984237
Peptides29469234

Function

PIGN · Phosphatidylinositol glycan anchor biosynthesis class N

This gene encodes a protein that is involved in glycosylphosphatidylinositol (GPI)-anchor biosynthesis. The GPI-anchor is a glycolipid found on many blood cells and serves to anchor proteins to the cell surface. This protein is expressed in the endoplasmic reticulum and transfers phosphoethanolamine (EtNP) to the first mannose of the GPI anchor. Two alternatively spliced variants, which encode an identical isoform, have been reported. [provided by RefSeq, Jul 2008].

Isoforms & Proteins

27 transcripts · UniProt mapping is sequence-verified (AA-safe)

About the isoform mapping
Isoforms & Proteins

Each Ensembl transcript (ENST) this gene is mutated on, with its matched UniProt accession.

The mapping is sequence-verified: the UniProt sequence is identical to the transcript translation, so amino-acid positions line up exactly. A * marks an unreviewed (TrEMBL) entry.

Counts are mutations and unique mutant peptides on each transcript.

TranscriptUniProtMutationsPeptides
ENST00000640252 O95427 351 248
ENST00000357637 O95427 298 233
ENST00000400334 O95427 298 233
ENST00000638936 O95427 298 233
ENST00000639902 A0A1W2PQA9* 298 233
ENST00000640050 O95427 298 233
ENST00000640145 O95427 298 233
ENST00000640540 A0A1W2PQA9* 298 233
ENST00000640876 O95427 298 233
ENST00000638977 A0A1W2PNH8* 296 231
ENST00000639758 A0A1W2PNH8* 296 231
ENST00000639912 A0A1W2PNH8* 296 231
ENST00000638183 A0A1W2PNR0* 288 224
ENST00000639174 A0A1W2PS19* 288 224
ENST00000639342 A0A1W2PNQ8* 276 218
ENST00000638369 A0A1W2PQP4* 270 216
ENST00000638435 A0A1W2PQR8* 265 206
ENST00000638167 A0A1W2PPR7* 259 207
ENST00000588571 K7ELE1* 157 117
ENST00000589339 K7ELE1* 157 117
ENST00000638329 K7ELE1* 157 117
ENST00000586566 K7EPJ2* 124 96
ENST00000591238 K7EMD7* 124 96
ENST00000638591 A0A1W2PRH3* 122 94
ENST00000585458 K7ESH9* 76 59
ENST00000589720 K7ESH9* 76 59
ENST00000639600 A0A1W2PR74* 3 2

Gene Properties

Type
Protein Coding
Chromosome
18
Cytoband
18q21.33
Entrez ID
23556
Aliases
GPI-ETIMCAHSMCAHS1MCD4MDC4PIG-N

Recurrent Mutations

Top recurrent amino-acid changes along the protein · needle height = number of mutations

What this lollipop shows
Recurrent Mutations

A lollipop / needle plot – the standard way to show recurrent mutations along a protein (as used by cBioPortal and MutationMapper).

X-axis = amino-acid position in the protein.

Needle height & head size = how often that exact amino-acid change was observed (its recurrence). Tall/large heads are mutational hotspots.

The most recurrent changes are labelled; hover any needle for the change, position and counts.

Mutation Distribution

Where PIGN is mutated · all tissues, split by cell line vs tissue

Mutation counts by tissue
Mutation Distribution

How many mutations in PIGN were found in each tissue, across the whole database.

Each bar is a tissue (cell-line and tissue names are merged to the standard tissue), split into cell line and tissue (patient tumour) contributions.

This shows the cancer-context where this gene is recurrently altered.

GTEx Expression

Median TPM across 54 healthy tissues

GTEx Portal ↗
About the expression data
GTEx Expression

Median gene expression (TPM) in normal, non-cancer human tissues from the GTEx project.

Useful for judging tumour specificity – a strong neoantigen target ideally comes from a gene with low expression in healthy tissues.

Scroll or drag the mini-axis below the chart to browse all tissues.

Mutations

All 6,265 mutations in PIGN

About the mutation list
Mutations

Every mutation record for this gene, across all samples and sources.

The Sample column links to the cell line (cell-line samples) or the tissue type (tissue samples).

Use the Type / Source filters, the search box, and column sorting to explore; each CAN-IMMUNE ID opens the full mutation & peptide view.

IDSampleTranscriptAA Change CDSTypeSourcePeptide