Stats by Source
Total, split by cell line (COSMIC CL / DepMap / PubMed) vs tissue (COSMIC primary tissue)
Total = all mutations for this gene across every source.
Cell line = COSMIC Cell Lines Project + DepMap + PubMed.
Tissue = COSMIC primary-tissue (patient tumour) samples.
Total can exceed cell line + tissue: COSMIC tissue-derived models sit only in global, and a peptide can be shared across both.
| Total | Cell line | Tissue | |
|---|---|---|---|
| Mutations | 1,401 | 166 | 1,224 |
| Samples | 668 | 102 | 561 |
| Peptides | 478 | 77 | 413 |
Function
PLCG1 · Phospholipase C gamma 1
The protein encoded by this gene catalyzes the formation of inositol 1,4,5-trisphosphate and diacylglycerol from phosphatidylinositol 4,5-bisphosphate. This reaction uses calcium as a cofactor and plays an important role in the intracellular transduction of receptor-mediated tyrosine kinase activators. For example, when activated by SRC, the encoded protein causes the Ras guanine nucleotide exchange factor RasGRP1 to translocate to the Golgi, where it activates Ras. Also, this protein has been shown to be a major substrate for heparin-binding growth factor 1 (acidic fibroblast growth factor)-activated tyrosine kinase. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008].
Isoforms & Proteins
3 transcripts · UniProt mapping is sequence-verified (AA-safe)
Each Ensembl transcript (ENST) this gene is mutated on, with its matched UniProt accession.
The mapping is sequence-verified: the UniProt sequence is identical to the transcript translation, so amino-acid positions line up exactly. A * marks an unreviewed (TrEMBL) entry.
Counts are mutations and unique mutant peptides on each transcript.
Gene Properties
Recurrent Mutations
All 445 amino-acid changes on canonical ENST00000373271 · needle height = samples · drag the mini-map to zoom
A lollipop / needle plot – the standard way to show recurrent mutations along a protein (as used by cBioPortal and MutationMapper).
X-axis = amino-acid position in the protein.
Needle height & head size = how often that exact amino-acid change was observed (its recurrence). Tall/large heads are mutational hotspots.
The most recurrent changes are labelled; hover any needle for the change, position and counts.
Mutation frequency across cancer types
% of samples with a missense/complex mutation in PLCG1 · cell line vs tissue
For each cancer type, the fraction of samples that carry at least one missense/complex mutation anywhere in PLCG1 – counted as distinct samples (a sample counts once no matter how many mutations it has).
Split into cell line and tissue; each cell shows mutated / total and the percentage. Cohorts with <20 samples are omitted. Ordered by combined frequency.
| Cancer type | Cell lines | Tissue samples |
|---|---|---|
| T-Lymphoblastic Leukemia | 4/40 10% | 0/0 0% |
| Endometrial Carcinoma | 9/42 21% | 23/612 4% |
| Gastrointestinal Stromal Tumour | 0/0 0% | 5/133 4% |
| Melanoma | 8/210 4% | 54/1899 3% |
| Gastric Carcinoma | 2/74 3% | 48/1809 3% |
| Colorectal Carcinoma | 19/143 13% | 69/3239 2% |
| Other Solid Cancers | 3/94 3% | 36/1515 2% |
| Bladder Carcinoma | 3/58 5% | 20/956 2% |
| Acute Myeloid Leukemia | 2/90 2% | 0/0 0% |
| Esophageal Carcinoma | 1/23 4% | 13/769 2% |
| B-Cell Non-Hodgkins Lymphoma | 4/88 5% | 41/2534 2% |
| Non-Small Cell Lung Carcinoma | 8/304 3% | 21/1390 2% |
| Other Sarcomas | 1/69 1% | 12/699 2% |
| Germ Cell Tumour | 1/25 4% | 2/169 1% |
| Cervical Carcinoma | 1/35 3% | 6/422 1% |
| Glioma | 0/52 0% | 32/2127 2% |
| Hodgkins Lymphoma | 0/16 0% | 2/122 2% |
| Squamous Cell Lung Carcinoma | 6/57 11% | 6/810 1% |
| Head and Neck Carcinoma | 0/85 0% | 21/1574 1% |
| Neuroendocrine Tumour | 3/154 2% | 6/577 1% |
| Esophageal Squamous Cell Carcinoma | 0/51 0% | 26/2550 1% |
| Ovarian Carcinoma | 5/109 5% | 6/998 1% |
| Non-Cancerous | 0/104 0% | 9/830 1% |
| Biliary Tract Carcinoma | 1/54 2% | 8/950 1% |
| Burkitts Lymphoma | 0/32 0% | 2/196 1% |
| Breast Carcinoma | 8/144 6% | 21/3264 1% |
| Hepatocellular Carcinoma | 1/46 2% | 18/2210 1% |
| Thyroid Gland Carcinoma | 1/45 2% | 12/1592 1% |
| Prostate Carcinoma | 0/13 0% | 14/2105 1% |
| Plasma Cell Myeloma | 0/44 0% | 2/305 1% |
Mutation Distribution
Where PLCG1 is mutated · all tissues, split by cell line vs tissue
How many mutations in PLCG1 were found in each tissue, across the whole database.
Each bar is a tissue (cell-line and tissue names are merged to the standard tissue), split into cell line and tissue (patient tumour) contributions.
This shows the cancer-context where this gene is recurrently altered.
GTEx Expression
Median TPM across 54 healthy tissues
Median gene expression (TPM) in normal, non-cancer human tissues from the GTEx project.
Useful for judging tumour specificity – a strong neoantigen target ideally comes from a gene with low expression in healthy tissues.
Scroll or drag the mini-axis below the chart to browse all tissues.
Mutations
All 1,401 mutations in PLCG1
Every mutation record for this gene, across all samples and sources.
The Sample column links to the cell line (cell-line samples) or the tissue type (tissue samples).
Use the Type / Source filters, the search box, and column sorting to explore; each CAN-IMMUNE ID opens the full mutation & peptide view.
| ID | Sample | Transcript | AA Change | CDS | Type | Source | Mutant Peptide | Wild-type Peptide |
|---|