Stats by Source
Total, split by cell line (COSMIC CL / DepMap / PubMed) vs tissue (COSMIC primary tissue)
Total = all mutations for this gene across every source.
Cell line = COSMIC Cell Lines Project + DepMap + PubMed.
Tissue = COSMIC primary-tissue (patient tumour) samples.
Total can exceed cell line + tissue: COSMIC tissue-derived models sit only in global, and a peptide can be shared across both.
| Total | Cell line | Tissue | |
|---|---|---|---|
| Mutations | 220 | 17 | 200 |
| Samples | 189 | 16 | 170 |
| Peptides | 161 | 13 | 148 |
Function
POC1B-GALNT4 · POC1B-GALNT4 readthrough
This locus represents naturally occurring transcripts that splice the 5' exons of the POC1B (POC1 centriolar protein homolog B) gene on chromosome 12 to the GALNT4 (UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 4) gene, which is located within a POC1B intron. Alternative splicing results in two transcript variants, one of which encodes a fusion isoform that shares sequence identity with the products of each individual gene. [provided by RefSeq, Dec 2010].
Isoforms & Proteins
2 transcripts · UniProt mapping is sequence-verified (AA-safe)
Each Ensembl transcript (ENST) this gene is mutated on, with its matched UniProt accession.
The mapping is sequence-verified: the UniProt sequence is identical to the transcript translation, so amino-acid positions line up exactly. A * marks an unreviewed (TrEMBL) entry.
Counts are mutations and unique mutant peptides on each transcript.
Gene Properties
Recurrent Mutations
All 155 amino-acid changes on canonical ENST00000548729 · needle height = samples · drag the mini-map to zoom
A lollipop / needle plot – the standard way to show recurrent mutations along a protein (as used by cBioPortal and MutationMapper).
X-axis = amino-acid position in the protein.
Needle height & head size = how often that exact amino-acid change was observed (its recurrence). Tall/large heads are mutational hotspots.
The most recurrent changes are labelled; hover any needle for the change, position and counts.
Mutation frequency across cancer types
% of samples with a missense/complex mutation in POC1B-GALNT4 · cell line vs tissue
For each cancer type, the fraction of samples that carry at least one missense/complex mutation anywhere in POC1B-GALNT4 – counted as distinct samples (a sample counts once no matter how many mutations it has).
Split into cell line and tissue; each cell shows mutated / total and the percentage. Cohorts with <20 samples are omitted. Ordered by combined frequency.
| Cancer type | Cell lines | Tissue samples |
|---|---|---|
| Chronic Myelogenous Leukemia | 2/25 8% | 0/0 0% |
| Gastrointestinal Stromal Tumour | 0/0 0% | 4/133 3% |
| Endometrial Carcinoma | 0/42 0% | 15/612 2% |
| Melanoma | 1/210 0% | 26/1899 1% |
| Glioblastoma | 1/98 1% | 0/0 0% |
| Non-Small Cell Lung Carcinoma | 5/304 2% | 9/1390 1% |
| Bladder Carcinoma | 0/58 0% | 8/956 1% |
| Gastric Carcinoma | 1/74 1% | 13/1809 1% |
| Other Solid Cancers | 1/94 1% | 10/1515 1% |
| Cervical Carcinoma | 0/35 0% | 3/422 1% |
| Colorectal Carcinoma | 0/143 0% | 20/3239 1% |
| Germ Cell Tumour | 0/25 0% | 1/169 1% |
| Hepatocellular Carcinoma | 0/46 0% | 11/2210 0% |
| Mesothelioma | 1/62 2% | 0/165 0% |
| Ovarian Carcinoma | 0/109 0% | 4/998 0% |
| Glioma | 1/52 2% | 6/2127 0% |
| Biliary Tract Carcinoma | 0/54 0% | 3/950 0% |
| Prostate Carcinoma | 0/13 0% | 6/2105 0% |
| Neuroblastoma | 0/87 0% | 4/1331 0% |
| Neuroendocrine Tumour | 1/154 1% | 1/577 0% |
| Esophageal Squamous Cell Carcinoma | 1/51 2% | 6/2550 0% |
| Head and Neck Carcinoma | 0/85 0% | 4/1574 0% |
| Squamous Cell Lung Carcinoma | 1/57 2% | 1/810 0% |
| Medulloblastoma | 0/0 0% | 1/450 0% |
| Kidney Carcinoma | 0/85 0% | 3/1862 0% |
| B-Cell Non-Hodgkins Lymphoma | 0/88 0% | 4/2534 0% |
| Other Sarcomas | 0/69 0% | 1/699 0% |
| Small Cell Lung Carcinoma | 0/9 0% | 1/752 0% |
| Breast Carcinoma | 0/144 0% | 4/3264 0% |
| Non-Cancerous | 0/104 0% | 1/830 0% |
Mutation Distribution
Where POC1B-GALNT4 is mutated · all tissues, split by cell line vs tissue
How many mutations in POC1B-GALNT4 were found in each tissue, across the whole database.
Each bar is a tissue (cell-line and tissue names are merged to the standard tissue), split into cell line and tissue (patient tumour) contributions.
This shows the cancer-context where this gene is recurrently altered.
Mutations
All 220 mutations in POC1B-GALNT4
Every mutation record for this gene, across all samples and sources.
The Sample column links to the cell line (cell-line samples) or the tissue type (tissue samples).
Use the Type / Source filters, the search box, and column sorting to explore; each CAN-IMMUNE ID opens the full mutation & peptide view.
| ID | Sample | Transcript | AA Change | CDS | Type | Source | Mutant Peptide | Wild-type Peptide |
|---|