Stats by Source
Total, split by cell line (COSMIC CL / DepMap / PubMed) vs tissue (COSMIC primary tissue)
Total = all mutations for this gene across every source.
Cell line = COSMIC Cell Lines Project + DepMap + PubMed.
Tissue = COSMIC primary-tissue (patient tumour) samples.
Total can exceed cell line + tissue: COSMIC tissue-derived models sit only in global, and a peptide can be shared across both.
| Total | Cell line | Tissue | |
|---|---|---|---|
| Mutations | 672 | 52 | 613 |
| Samples | 169 | 22 | 144 |
| Peptides | 137 | 21 | 115 |
Function
PON2 · Paraoxonase 2
This gene encodes a member of the paraoxonase gene family, which includes three known members located adjacent to each other on the long arm of chromosome 7. The encoded protein is ubiquitously expressed in human tissues, membrane-bound, and may act as a cellular antioxidant, protecting cells from oxidative stress. Hydrolytic activity against acylhomoserine lactones, important bacterial quorum-sensing mediators, suggests the encoded protein may also play a role in defense responses to pathogenic bacteria. Mutations in this gene may be associated with vascular disease and a number of quantitative phenotypes related to diabetes. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jul 2008].
Isoforms & Proteins
5 transcripts · UniProt mapping is sequence-verified (AA-safe)
Each Ensembl transcript (ENST) this gene is mutated on, with its matched UniProt accession.
The mapping is sequence-verified: the UniProt sequence is identical to the transcript translation, so amino-acid positions line up exactly. A * marks an unreviewed (TrEMBL) entry.
Counts are mutations and unique mutant peptides on each transcript.
| Transcript | UniProt | Mutations | Peptides |
|---|---|---|---|
| ENST00000222572 | Q15165 | 176 | 116 |
| ENST00000633192 | A0A0J9YXF2* | 172 | 115 |
| ENST00000633531 | Q15165 | 163 | 109 |
| ENST00000433091 | Q15165-3 | 160 | 106 |
| ENST00000455123 | G3XAK4* | 1 | 1 |
Gene Properties
Recurrent Mutations
All 116 amino-acid changes on canonical ENST00000222572 · needle height = samples · drag the mini-map to zoom
A lollipop / needle plot – the standard way to show recurrent mutations along a protein (as used by cBioPortal and MutationMapper).
X-axis = amino-acid position in the protein.
Needle height & head size = how often that exact amino-acid change was observed (its recurrence). Tall/large heads are mutational hotspots.
The most recurrent changes are labelled; hover any needle for the change, position and counts.
Mutation frequency across cancer types
% of samples with a missense/complex mutation in PON2 · cell line vs tissue
For each cancer type, the fraction of samples that carry at least one missense/complex mutation anywhere in PON2 – counted as distinct samples (a sample counts once no matter how many mutations it has).
Split into cell line and tissue; each cell shows mutated / total and the percentage. Cohorts with <20 samples are omitted. Ordered by combined frequency.
| Cancer type | Cell lines | Tissue samples |
|---|---|---|
| Rhabdomyosarcoma | 0/33 0% | 8/171 5% |
| Endometrial Carcinoma | 1/42 2% | 11/612 2% |
| Acute Myeloid Leukemia | 1/90 1% | 0/0 0% |
| Bladder Carcinoma | 0/58 0% | 11/956 1% |
| Glioblastoma | 1/98 1% | 0/0 0% |
| Melanoma | 2/210 1% | 15/1899 1% |
| Hodgkins Lymphoma | 0/16 0% | 1/122 1% |
| Gastric Carcinoma | 2/74 3% | 11/1809 1% |
| Non-Cancerous | 1/104 1% | 5/830 1% |
| Other Solid Cancers | 0/94 0% | 9/1515 1% |
| Colorectal Carcinoma | 5/143 4% | 13/3239 0% |
| Cervical Carcinoma | 0/35 0% | 2/422 0% |
| Other Sarcomas | 2/69 3% | 1/699 0% |
| Glioma | 0/52 0% | 7/2127 0% |
| B-Cell Non-Hodgkins Lymphoma | 3/88 3% | 5/2534 0% |
| Hepatocellular Carcinoma | 0/46 0% | 7/2210 0% |
| Plasma Cell Myeloma | 0/44 0% | 1/305 0% |
| Neuroendocrine Tumour | 1/154 1% | 1/577 0% |
| Ovarian Carcinoma | 1/109 1% | 2/998 0% |
| Small Cell Lung Carcinoma | 0/9 0% | 2/752 0% |
| Esophageal Carcinoma | 0/23 0% | 2/769 0% |
| Other Blood Cancers | 0/61 0% | 6/2725 0% |
| Medulloblastoma | 0/0 0% | 1/450 0% |
| Prostate Carcinoma | 0/13 0% | 4/2105 0% |
| Head and Neck Carcinoma | 0/85 0% | 3/1574 0% |
| Esophageal Squamous Cell Carcinoma | 0/51 0% | 4/2550 0% |
| Breast Carcinoma | 1/144 1% | 4/3264 0% |
| Non-Small Cell Lung Carcinoma | 0/304 0% | 2/1390 0% |
| Pancreatic Carcinoma | 0/89 0% | 2/1611 0% |
| Squamous Cell Lung Carcinoma | 0/57 0% | 1/810 0% |
Mutation Distribution
Where PON2 is mutated · all tissues, split by cell line vs tissue
How many mutations in PON2 were found in each tissue, across the whole database.
Each bar is a tissue (cell-line and tissue names are merged to the standard tissue), split into cell line and tissue (patient tumour) contributions.
This shows the cancer-context where this gene is recurrently altered.
GTEx Expression
Median TPM across 54 healthy tissues
Median gene expression (TPM) in normal, non-cancer human tissues from the GTEx project.
Useful for judging tumour specificity – a strong neoantigen target ideally comes from a gene with low expression in healthy tissues.
Scroll or drag the mini-axis below the chart to browse all tissues.
Mutations
All 672 mutations in PON2
Every mutation record for this gene, across all samples and sources.
The Sample column links to the cell line (cell-line samples) or the tissue type (tissue samples).
Use the Type / Source filters, the search box, and column sorting to explore; each CAN-IMMUNE ID opens the full mutation & peptide view.
| ID | Sample | Transcript | AA Change | CDS | Type | Source | Mutant Peptide | Wild-type Peptide |
|---|