Stats by Source
Total, split by cell line (COSMIC CL / DepMap / PubMed) vs tissue (COSMIC primary tissue)
Total = all mutations for this gene across every source.
Cell line = COSMIC Cell Lines Project + DepMap + PubMed.
Tissue = COSMIC primary-tissue (patient tumour) samples.
Total can exceed cell line + tissue: COSMIC tissue-derived models sit only in global, and a peptide can be shared across both.
| Total | Cell line | Tissue | |
|---|---|---|---|
| Mutations | 620 | 71 | 531 |
| Samples | 402 | 47 | 345 |
| Peptides | 311 | 52 | 272 |
Function
PPAN-P2RY11 · PPAN-P2RY11 readthrough
This locus represents naturally occurring read-through transcription between the adjacent PPAN and P2RY11 genes. Alternative splicing results in two transcript variants, one of which encodes a fusion protein that shares sequence identity with each individual gene product. This transcript is found to be ubiquitously expressed and is up-regulated by agents inducing granulocytic differentiation. However, its functional significance in vivo remains unclear. [provided by RefSeq, Nov 2010].
Isoforms & Proteins
2 transcripts · UniProt mapping is sequence-verified (AA-safe)
Each Ensembl transcript (ENST) this gene is mutated on, with its matched UniProt accession.
The mapping is sequence-verified: the UniProt sequence is identical to the transcript translation, so amino-acid positions line up exactly. A * marks an unreviewed (TrEMBL) entry.
Counts are mutations and unique mutant peptides on each transcript.
| Transcript | UniProt | Mutations | Peptides |
|---|---|---|---|
| ENST00000393796 | A0A0B4J1V8* | 368 | 268 |
| ENST00000428358 | Q9NQ55-3 | 252 | 167 |
Gene Properties
Recurrent Mutations
All 167 amino-acid changes on canonical ENST00000428358 · needle height = samples · drag the mini-map to zoom
A lollipop / needle plot – the standard way to show recurrent mutations along a protein (as used by cBioPortal and MutationMapper).
X-axis = amino-acid position in the protein.
Needle height & head size = how often that exact amino-acid change was observed (its recurrence). Tall/large heads are mutational hotspots.
The most recurrent changes are labelled; hover any needle for the change, position and counts.
Mutation frequency across cancer types
% of samples with a missense/complex mutation in PPAN-P2RY11 · cell line vs tissue
For each cancer type, the fraction of samples that carry at least one missense/complex mutation anywhere in PPAN-P2RY11 – counted as distinct samples (a sample counts once no matter how many mutations it has).
Split into cell line and tissue; each cell shows mutated / total and the percentage. Cohorts with <20 samples are omitted. Ordered by combined frequency.
| Cancer type | Cell lines | Tissue samples |
|---|---|---|
| Chronic Myelogenous Leukemia | 2/25 8% | 0/0 0% |
| T-Lymphoblastic Leukemia | 2/40 5% | 0/0 0% |
| Endometrial Carcinoma | 0/42 0% | 26/612 4% |
| Gastrointestinal Stromal Tumour | 0/0 0% | 5/133 4% |
| Glioblastoma | 2/98 2% | 0/0 0% |
| Colorectal Carcinoma | 7/143 5% | 59/3239 2% |
| Oral Cavity Carcinoma | 1/54 2% | 0/0 0% |
| Melanoma | 3/210 1% | 35/1899 2% |
| Rhabdomyosarcoma | 2/33 6% | 1/171 1% |
| Hodgkins Lymphoma | 1/16 6% | 1/122 1% |
| Non-Small Cell Lung Carcinoma | 2/304 1% | 19/1390 1% |
| Bladder Carcinoma | 0/58 0% | 12/956 1% |
| Acute Myeloid Leukemia | 1/90 1% | 0/0 0% |
| Other Solid Cancers | 3/94 3% | 14/1515 1% |
| Squamous Cell Lung Carcinoma | 1/57 2% | 8/810 1% |
| Germ Cell Tumour | 0/25 0% | 2/169 1% |
| Gastric Carcinoma | 2/74 3% | 17/1809 1% |
| Esophageal Squamous Cell Carcinoma | 0/51 0% | 24/2550 1% |
| Hepatocellular Carcinoma | 0/46 0% | 20/2210 1% |
| Burkitts Lymphoma | 1/32 3% | 1/196 1% |
| Non-Cancerous | 0/104 0% | 8/830 1% |
| Biliary Tract Carcinoma | 0/54 0% | 8/950 1% |
| Glioma | 0/52 0% | 15/2127 1% |
| Head and Neck Carcinoma | 1/85 1% | 10/1574 1% |
| Thyroid Gland Carcinoma | 0/45 0% | 9/1592 1% |
| Small Cell Lung Carcinoma | 0/9 0% | 4/752 1% |
| Other Sarcomas | 1/69 1% | 3/699 0% |
| Osteosarcoma | 1/45 2% | 0/166 0% |
| Breast Carcinoma | 3/144 2% | 13/3264 0% |
| Ovarian Carcinoma | 0/109 0% | 5/998 0% |
Mutation Distribution
Where PPAN-P2RY11 is mutated · all tissues, split by cell line vs tissue
How many mutations in PPAN-P2RY11 were found in each tissue, across the whole database.
Each bar is a tissue (cell-line and tissue names are merged to the standard tissue), split into cell line and tissue (patient tumour) contributions.
This shows the cancer-context where this gene is recurrently altered.
Mutations
All 620 mutations in PPAN-P2RY11
Every mutation record for this gene, across all samples and sources.
The Sample column links to the cell line (cell-line samples) or the tissue type (tissue samples).
Use the Type / Source filters, the search box, and column sorting to explore; each CAN-IMMUNE ID opens the full mutation & peptide view.
| ID | Sample | Transcript | AA Change | CDS | Type | Source | Mutant Peptide | Wild-type Peptide |
|---|