Stats by Source
Total, split by cell line (COSMIC CL / DepMap / PubMed) vs tissue (COSMIC primary tissue)
Total = all mutations for this gene across every source.
Cell line = COSMIC Cell Lines Project + DepMap + PubMed.
Tissue = COSMIC primary-tissue (patient tumour) samples.
Total can exceed cell line + tissue: COSMIC tissue-derived models sit only in global, and a peptide can be shared across both.
| Total | Cell line | Tissue | |
|---|---|---|---|
| Mutations | 841 | 127 | 708 |
| Samples | 496 | 92 | 400 |
| Peptides | 289 | 61 | 251 |
Function
PPP2R1A · Protein phosphatase 2 scaffold subunit Aalpha
This gene encodes a constant regulatory subunit of protein phosphatase 2. Protein phosphatase 2 is one of the four major Ser/Thr phosphatases, and it is implicated in the negative control of cell growth and division. It consists of a common heteromeric core enzyme, which is composed of a catalytic subunit and a constant regulatory subunit, that associates with a variety of regulatory subunits. The constant regulatory subunit A serves as a scaffolding molecule to coordinate the assembly of the catalytic subunit and a variable regulatory B subunit. This gene encodes an alpha isoform of the constant regulatory subunit A. Alternatively spliced transcript variants have been described. [provided by RefSeq, Apr 2010].
Isoforms & Proteins
3 transcripts · UniProt mapping is sequence-verified (AA-safe)
Each Ensembl transcript (ENST) this gene is mutated on, with its matched UniProt accession.
The mapping is sequence-verified: the UniProt sequence is identical to the transcript translation, so amino-acid positions line up exactly. A * marks an unreviewed (TrEMBL) entry.
Counts are mutations and unique mutant peptides on each transcript.
Gene Properties
Recurrent Mutations
All 274 amino-acid changes on canonical ENST00000322088 · needle height = samples · drag the mini-map to zoom
A lollipop / needle plot – the standard way to show recurrent mutations along a protein (as used by cBioPortal and MutationMapper).
X-axis = amino-acid position in the protein.
Needle height & head size = how often that exact amino-acid change was observed (its recurrence). Tall/large heads are mutational hotspots.
The most recurrent changes are labelled; hover any needle for the change, position and counts.
Mutation frequency across cancer types
% of samples with a missense/complex mutation in PPP2R1A · cell line vs tissue
For each cancer type, the fraction of samples that carry at least one missense/complex mutation anywhere in PPP2R1A – counted as distinct samples (a sample counts once no matter how many mutations it has).
Split into cell line and tissue; each cell shows mutated / total and the percentage. Cohorts with <20 samples are omitted. Ordered by combined frequency.
| Cancer type | Cell lines | Tissue samples |
|---|---|---|
| Endometrial Carcinoma | 15/42 36% | 91/612 15% |
| T-Lymphoblastic Leukemia | 2/40 5% | 0/0 0% |
| Acute Monocytic Leukemia | 0/1 0% | 1/25 4% |
| Oral Cavity Carcinoma | 2/54 4% | 0/0 0% |
| Ovarian Carcinoma | 14/109 13% | 12/998 1% |
| Colorectal Carcinoma | 14/143 10% | 59/3239 2% |
| Non-Small Cell Lung Carcinoma | 9/304 3% | 22/1390 2% |
| Other Sarcomas | 0/69 0% | 14/699 2% |
| Squamous Cell Lung Carcinoma | 2/57 4% | 12/810 1% |
| Germ Cell Tumour | 3/25 12% | 0/169 0% |
| Melanoma | 6/210 3% | 26/1899 1% |
| Cervical Carcinoma | 1/35 3% | 5/422 1% |
| Gastric Carcinoma | 0/74 0% | 24/1809 1% |
| Acute Myeloid Leukemia | 1/90 1% | 0/0 0% |
| Neuroendocrine Tumour | 3/154 2% | 5/577 1% |
| Glioblastoma | 1/98 1% | 0/0 0% |
| Esophageal Carcinoma | 0/23 0% | 7/769 1% |
| Esophageal Squamous Cell Carcinoma | 2/51 4% | 20/2550 1% |
| Small Cell Lung Carcinoma | 0/9 0% | 6/752 1% |
| Breast Carcinoma | 5/144 3% | 17/3264 1% |
| Other Solid Cancers | 0/94 0% | 10/1515 1% |
| Bladder Carcinoma | 0/58 0% | 6/956 1% |
| Hepatocellular Carcinoma | 0/46 0% | 13/2210 1% |
| Thyroid Gland Carcinoma | 1/45 2% | 8/1592 0% |
| Non-Cancerous | 0/104 0% | 5/830 1% |
| Glioma | 0/52 0% | 11/2127 1% |
| Rhabdomyosarcoma | 0/33 0% | 1/171 1% |
| Head and Neck Carcinoma | 1/85 1% | 7/1574 0% |
| Pancreatic Carcinoma | 2/89 2% | 6/1611 0% |
| Osteosarcoma | 1/45 2% | 0/166 0% |
Mutation Distribution
Where PPP2R1A is mutated · all tissues, split by cell line vs tissue
How many mutations in PPP2R1A were found in each tissue, across the whole database.
Each bar is a tissue (cell-line and tissue names are merged to the standard tissue), split into cell line and tissue (patient tumour) contributions.
This shows the cancer-context where this gene is recurrently altered.
GTEx Expression
Median TPM across 54 healthy tissues
Median gene expression (TPM) in normal, non-cancer human tissues from the GTEx project.
Useful for judging tumour specificity – a strong neoantigen target ideally comes from a gene with low expression in healthy tissues.
Scroll or drag the mini-axis below the chart to browse all tissues.
Mutations
All 841 mutations in PPP2R1A
Every mutation record for this gene, across all samples and sources.
The Sample column links to the cell line (cell-line samples) or the tissue type (tissue samples).
Use the Type / Source filters, the search box, and column sorting to explore; each CAN-IMMUNE ID opens the full mutation & peptide view.
| ID | Sample | Transcript | AA Change | CDS | Type | Source | Mutant Peptide | Wild-type Peptide |
|---|