Stats by Source
Total, split by cell line (COSMIC CL / DepMap / PubMed) vs tissue (COSMIC primary tissue)
Total = all mutations for this gene across every source.
Cell line = COSMIC Cell Lines Project + DepMap + PubMed.
Tissue = COSMIC primary-tissue (patient tumour) samples.
Total can exceed cell line + tissue: COSMIC tissue-derived models sit only in global, and a peptide can be shared across both.
| Total | Cell line | Tissue | |
|---|---|---|---|
| Mutations | 1,257 | 90 | 1,164 |
| Samples | 266 | 35 | 230 |
| Peptides | 268 | 27 | 243 |
Function
PPP2R5C · Protein phosphatase 2 regulatory subunit B'gamma
The product of this gene belongs to the phosphatase 2A regulatory subunit B family. Protein phosphatase 2A is one of the four major Ser/Thr phosphatases, and it is implicated in the negative control of cell growth and division. It consists of a common heteromeric core enzyme, which is composed of a catalytic subunit and a constant regulatory subunit, that associates with a variety of regulatory subunits. The B regulatory subunit might modulate substrate selectivity and catalytic activity. This gene encodes a gamma isoform of the regulatory subunit B56 subfamily. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008].
Isoforms & Proteins
11 transcripts · UniProt mapping is sequence-verified (AA-safe)
Each Ensembl transcript (ENST) this gene is mutated on, with its matched UniProt accession.
The mapping is sequence-verified: the UniProt sequence is identical to the transcript translation, so amino-acid positions line up exactly. A * marks an unreviewed (TrEMBL) entry.
Counts are mutations and unique mutant peptides on each transcript.
| Transcript | UniProt | Mutations | Peptides |
|---|---|---|---|
| ENST00000422945 | Q13362-5 | 219 | 173 |
| ENST00000328724 | Q13362-4 | 215 | 170 |
| ENST00000334743 | Q13362 | 211 | 170 |
| ENST00000350249 | Q13362-3 | 205 | 163 |
| ENST00000445439 | Q13362-2 | 168 | 140 |
| ENST00000557095 | G3V3D0* | 144 | 123 |
| ENST00000554442 | G3V292* | 29 | 25 |
| ENST00000694906 | A0A8Q3WKR3* | 20 | 18 |
| ENST00000556946 | H0YNR8* | 17 | 17 |
| ENST00000557714 | H0YK25* | 16 | 16 |
| ENST00000556260 | H0YNJ3* | 13 | 9 |
Gene Properties
Recurrent Mutations
All 173 amino-acid changes on canonical ENST00000422945 · needle height = samples · drag the mini-map to zoom
A lollipop / needle plot – the standard way to show recurrent mutations along a protein (as used by cBioPortal and MutationMapper).
X-axis = amino-acid position in the protein.
Needle height & head size = how often that exact amino-acid change was observed (its recurrence). Tall/large heads are mutational hotspots.
The most recurrent changes are labelled; hover any needle for the change, position and counts.
Mutation frequency across cancer types
% of samples with a missense/complex mutation in PPP2R5C · cell line vs tissue
For each cancer type, the fraction of samples that carry at least one missense/complex mutation anywhere in PPP2R5C – counted as distinct samples (a sample counts once no matter how many mutations it has).
Split into cell line and tissue; each cell shows mutated / total and the percentage. Cohorts with <20 samples are omitted. Ordered by combined frequency.
| Cancer type | Cell lines | Tissue samples |
|---|---|---|
| Endometrial Carcinoma | 9/42 21% | 15/612 2% |
| Glioblastoma | 3/98 3% | 0/0 0% |
| Melanoma | 2/210 1% | 34/1899 2% |
| Gastrointestinal Stromal Tumour | 0/0 0% | 2/133 2% |
| Chondrosarcoma | 0/14 0% | 1/75 1% |
| Cervical Carcinoma | 0/35 0% | 5/422 1% |
| Squamous Cell Lung Carcinoma | 1/57 2% | 8/810 1% |
| Small Cell Lung Carcinoma | 0/9 0% | 7/752 1% |
| Bladder Carcinoma | 0/58 0% | 9/956 1% |
| Adrenocortical Carcinoma | 0/3 0% | 1/112 1% |
| Non-Cancerous | 1/104 1% | 7/830 1% |
| Gastric Carcinoma | 0/74 0% | 16/1809 1% |
| Colorectal Carcinoma | 2/143 1% | 25/3239 1% |
| Other Solid Cancers | 0/94 0% | 12/1515 1% |
| Neuroendocrine Tumour | 2/154 1% | 3/577 1% |
| Biliary Tract Carcinoma | 0/54 0% | 6/950 1% |
| Non-Small Cell Lung Carcinoma | 2/304 1% | 8/1390 1% |
| Head and Neck Carcinoma | 1/85 1% | 8/1574 1% |
| Hepatocellular Carcinoma | 0/46 0% | 12/2210 1% |
| Germ Cell Tumour | 0/25 0% | 1/169 1% |
| Thyroid Gland Carcinoma | 0/45 0% | 7/1592 0% |
| Breast Carcinoma | 3/144 2% | 11/3264 0% |
| Other Sarcomas | 0/69 0% | 3/699 0% |
| Esophageal Squamous Cell Carcinoma | 0/51 0% | 10/2550 0% |
| Other Blood Cancers | 4/61 7% | 4/2725 0% |
| Ovarian Carcinoma | 0/109 0% | 3/998 0% |
| Glioma | 0/52 0% | 5/2127 0% |
| Kidney Carcinoma | 0/85 0% | 3/1862 0% |
| B-Cell Non-Hodgkins Lymphoma | 2/88 2% | 2/2534 0% |
| Esophageal Carcinoma | 0/23 0% | 1/769 0% |
Mutation Distribution
Where PPP2R5C is mutated · all tissues, split by cell line vs tissue
How many mutations in PPP2R5C were found in each tissue, across the whole database.
Each bar is a tissue (cell-line and tissue names are merged to the standard tissue), split into cell line and tissue (patient tumour) contributions.
This shows the cancer-context where this gene is recurrently altered.
GTEx Expression
Median TPM across 54 healthy tissues
Median gene expression (TPM) in normal, non-cancer human tissues from the GTEx project.
Useful for judging tumour specificity – a strong neoantigen target ideally comes from a gene with low expression in healthy tissues.
Scroll or drag the mini-axis below the chart to browse all tissues.
Mutations
All 1,257 mutations in PPP2R5C
Every mutation record for this gene, across all samples and sources.
The Sample column links to the cell line (cell-line samples) or the tissue type (tissue samples).
Use the Type / Source filters, the search box, and column sorting to explore; each CAN-IMMUNE ID opens the full mutation & peptide view.
| ID | Sample | Transcript | AA Change | CDS | Type | Source | Mutant Peptide | Wild-type Peptide |
|---|