Stats by Source
Total, split by cell line (COSMIC CL / DepMap / PubMed) vs tissue (COSMIC primary tissue)
Total = all mutations for this gene across every source.
Cell line = COSMIC Cell Lines Project + DepMap + PubMed.
Tissue = COSMIC primary-tissue (patient tumour) samples.
Total can exceed cell line + tissue: COSMIC tissue-derived models sit only in global, and a peptide can be shared across both.
| Total | Cell line | Tissue | |
|---|---|---|---|
| Mutations | 404 | 61 | 336 |
| Samples | 236 | 43 | 187 |
| Peptides | 188 | 32 | 158 |
Function
PPP5C · Protein phosphatase 5 catalytic subunit
This gene encodes a serine/threonine phosphatase which is a member of the protein phosphatase catalytic subunit family. Proteins in this family participate in pathways regulated by reversible phosphorylation at serine and threonine residues; many of these pathways are involved in the regulation of cell growth and differentiation. The product of this gene has been shown to participate in signaling pathways in response to hormones or cellular stress, and elevated levels of this protein may be associated with breast cancer development. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2011].
Isoforms & Proteins
2 transcripts · UniProt mapping is sequence-verified (AA-safe)
Each Ensembl transcript (ENST) this gene is mutated on, with its matched UniProt accession.
The mapping is sequence-verified: the UniProt sequence is identical to the transcript translation, so amino-acid positions line up exactly. A * marks an unreviewed (TrEMBL) entry.
Counts are mutations and unique mutant peptides on each transcript.
Gene Properties
Recurrent Mutations
All 179 amino-acid changes on canonical ENST00000012443 · needle height = samples · drag the mini-map to zoom
A lollipop / needle plot – the standard way to show recurrent mutations along a protein (as used by cBioPortal and MutationMapper).
X-axis = amino-acid position in the protein.
Needle height & head size = how often that exact amino-acid change was observed (its recurrence). Tall/large heads are mutational hotspots.
The most recurrent changes are labelled; hover any needle for the change, position and counts.
Mutation frequency across cancer types
% of samples with a missense/complex mutation in PPP5C · cell line vs tissue
For each cancer type, the fraction of samples that carry at least one missense/complex mutation anywhere in PPP5C – counted as distinct samples (a sample counts once no matter how many mutations it has).
Split into cell line and tissue; each cell shows mutated / total and the percentage. Cohorts with <20 samples are omitted. Ordered by combined frequency.
| Cancer type | Cell lines | Tissue samples |
|---|---|---|
| T-Cell Non-Hodgkins Lymphoma | 1/26 4% | 0/0 0% |
| Endometrial Carcinoma | 4/42 10% | 16/612 3% |
| Bladder Carcinoma | 6/58 10% | 8/956 1% |
| Colorectal Carcinoma | 10/143 7% | 33/3239 1% |
| Melanoma | 2/210 1% | 23/1899 1% |
| Cervical Carcinoma | 0/35 0% | 5/422 1% |
| Glioblastoma | 1/98 1% | 0/0 0% |
| Gastric Carcinoma | 0/74 0% | 17/1809 1% |
| Non-Small Cell Lung Carcinoma | 8/304 3% | 7/1390 0% |
| Biliary Tract Carcinoma | 0/54 0% | 6/950 1% |
| Other Sarcomas | 1/69 1% | 3/699 0% |
| Esophageal Carcinoma | 0/23 0% | 4/769 1% |
| Hepatocellular Carcinoma | 0/46 0% | 11/2210 0% |
| Glioma | 1/52 2% | 9/2127 0% |
| Other Solid Cancers | 0/94 0% | 7/1515 0% |
| Head and Neck Carcinoma | 0/85 0% | 6/1574 0% |
| Ewings Sarcoma | 0/63 0% | 1/262 0% |
| Plasma Cell Myeloma | 1/44 2% | 0/305 0% |
| Neuroendocrine Tumour | 1/154 1% | 1/577 0% |
| Ovarian Carcinoma | 2/109 2% | 1/998 0% |
| Pancreatic Carcinoma | 0/89 0% | 4/1611 0% |
| Breast Carcinoma | 0/144 0% | 8/3264 0% |
| Kidney Carcinoma | 0/85 0% | 4/1862 0% |
| Non-Cancerous | 1/104 1% | 1/830 0% |
| B-Cell Non-Hodgkins Lymphoma | 0/88 0% | 5/2534 0% |
| Prostate Carcinoma | 0/13 0% | 4/2105 0% |
| Esophageal Squamous Cell Carcinoma | 0/51 0% | 4/2550 0% |
| Small Cell Lung Carcinoma | 0/9 0% | 1/752 0% |
| Squamous Cell Lung Carcinoma | 0/57 0% | 1/810 0% |
| Thyroid Gland Carcinoma | 0/45 0% | 2/1592 0% |
Mutation Distribution
Where PPP5C is mutated · all tissues, split by cell line vs tissue
How many mutations in PPP5C were found in each tissue, across the whole database.
Each bar is a tissue (cell-line and tissue names are merged to the standard tissue), split into cell line and tissue (patient tumour) contributions.
This shows the cancer-context where this gene is recurrently altered.
GTEx Expression
Median TPM across 54 healthy tissues
Median gene expression (TPM) in normal, non-cancer human tissues from the GTEx project.
Useful for judging tumour specificity – a strong neoantigen target ideally comes from a gene with low expression in healthy tissues.
Scroll or drag the mini-axis below the chart to browse all tissues.
Mutations
All 404 mutations in PPP5C
Every mutation record for this gene, across all samples and sources.
The Sample column links to the cell line (cell-line samples) or the tissue type (tissue samples).
Use the Type / Source filters, the search box, and column sorting to explore; each CAN-IMMUNE ID opens the full mutation & peptide view.
| ID | Sample | Transcript | AA Change | CDS | Type | Source | Mutant Peptide | Wild-type Peptide |
|---|