Stats by Source
Total, split by cell line (COSMIC CL / DepMap / PubMed) vs tissue (COSMIC primary tissue)
Total = all mutations for this gene across every source.
Cell line = COSMIC Cell Lines Project + DepMap + PubMed.
Tissue = COSMIC primary-tissue (patient tumour) samples.
Total can exceed cell line + tissue: COSMIC tissue-derived models sit only in global, and a peptide can be shared across both.
| Total | Cell line | Tissue | |
|---|---|---|---|
| Mutations | 1,280 | 118 | 1,154 |
| Samples | 473 | 54 | 415 |
| Peptides | 238 | 48 | 216 |
Function
PRB4 · Proline rich protein BstNI subfamily 4
This gene encodes a member of the heterogeneous family of basic, proline-rich, human salivary glycoproteins. The encoded preproprotein undergoes proteolytic processing to generate one or more mature peptides before secretion from the parotid glands. Multiple alleles of this gene exhibiting variations in the length of the tandem repeats have been identified. The reference genome encodes the 'Small' allele. This gene is located in a cluster of closely related salivary proline-rich proteins on chromosome 12. Alternative splicing results in multiple transcript variants encoding different isoforms that may undergo similar proteolytic processing. [provided by RefSeq, Nov 2015].
Isoforms & Proteins
3 transcripts · UniProt mapping is sequence-verified (AA-safe)
Each Ensembl transcript (ENST) this gene is mutated on, with its matched UniProt accession.
The mapping is sequence-verified: the UniProt sequence is identical to the transcript translation, so amino-acid positions line up exactly. A * marks an unreviewed (TrEMBL) entry.
Counts are mutations and unique mutant peptides on each transcript.
Gene Properties
Recurrent Mutations
All 221 amino-acid changes on canonical ENST00000279575 · needle height = samples · drag the mini-map to zoom
A lollipop / needle plot – the standard way to show recurrent mutations along a protein (as used by cBioPortal and MutationMapper).
X-axis = amino-acid position in the protein.
Needle height & head size = how often that exact amino-acid change was observed (its recurrence). Tall/large heads are mutational hotspots.
The most recurrent changes are labelled; hover any needle for the change, position and counts.
Mutation frequency across cancer types
% of samples with a missense/complex mutation in PRB4 · cell line vs tissue
For each cancer type, the fraction of samples that carry at least one missense/complex mutation anywhere in PRB4 – counted as distinct samples (a sample counts once no matter how many mutations it has).
Split into cell line and tissue; each cell shows mutated / total and the percentage. Cohorts with <20 samples are omitted. Ordered by combined frequency.
| Cancer type | Cell lines | Tissue samples |
|---|---|---|
| Melanoma | 7/210 3% | 79/1899 4% |
| T-Cell Non-Hodgkins Lymphoma | 1/26 4% | 0/0 0% |
| Gastrointestinal Stromal Tumour | 0/0 0% | 5/133 4% |
| Other Solid Cancers | 2/94 2% | 40/1515 3% |
| Squamous Cell Lung Carcinoma | 1/57 2% | 21/810 3% |
| Cervical Carcinoma | 4/35 11% | 6/422 1% |
| Glioblastoma | 2/98 2% | 0/0 0% |
| Colorectal Carcinoma | 6/143 4% | 58/3239 2% |
| Endometrial Carcinoma | 0/42 0% | 11/612 2% |
| Thyroid Gland Carcinoma | 0/45 0% | 24/1592 2% |
| Osteosarcoma | 1/45 2% | 2/166 1% |
| Non-Small Cell Lung Carcinoma | 6/304 2% | 15/1390 1% |
| Meningioma | 0/3 0% | 3/252 1% |
| Chondrosarcoma | 1/14 7% | 0/75 0% |
| Acute Myeloid Leukemia | 1/90 1% | 0/0 0% |
| Biliary Tract Carcinoma | 0/54 0% | 10/950 1% |
| Bladder Carcinoma | 0/58 0% | 10/956 1% |
| Pancreatic Carcinoma | 1/89 1% | 15/1611 1% |
| Esophageal Carcinoma | 0/23 0% | 7/769 1% |
| Adrenocortical Carcinoma | 0/3 0% | 1/112 1% |
| Gastric Carcinoma | 1/74 1% | 14/1809 1% |
| Other Sarcomas | 4/69 6% | 2/699 0% |
| Prostate Carcinoma | 0/13 0% | 15/2105 1% |
| Other Blood Cancers | 3/61 5% | 15/2725 1% |
| Neuroendocrine Tumour | 3/154 2% | 1/577 0% |
| Non-Cancerous | 0/104 0% | 5/830 1% |
| Head and Neck Carcinoma | 1/85 1% | 8/1574 1% |
| Small Cell Lung Carcinoma | 0/9 0% | 4/752 1% |
| Esophageal Squamous Cell Carcinoma | 0/51 0% | 11/2550 0% |
| Glioma | 0/52 0% | 8/2127 0% |
Mutation Distribution
Where PRB4 is mutated · all tissues, split by cell line vs tissue
How many mutations in PRB4 were found in each tissue, across the whole database.
Each bar is a tissue (cell-line and tissue names are merged to the standard tissue), split into cell line and tissue (patient tumour) contributions.
This shows the cancer-context where this gene is recurrently altered.
GTEx Expression
Median TPM across 3 healthy tissues
Median gene expression (TPM) in normal, non-cancer human tissues from the GTEx project.
Useful for judging tumour specificity – a strong neoantigen target ideally comes from a gene with low expression in healthy tissues.
Scroll or drag the mini-axis below the chart to browse all tissues.
Mutations
All 1,280 mutations in PRB4
Every mutation record for this gene, across all samples and sources.
The Sample column links to the cell line (cell-line samples) or the tissue type (tissue samples).
Use the Type / Source filters, the search box, and column sorting to explore; each CAN-IMMUNE ID opens the full mutation & peptide view.
| ID | Sample | Transcript | AA Change | CDS | Type | Source | Mutant Peptide | Wild-type Peptide |
|---|