Stats by Source
Total, split by cell line (COSMIC CL / DepMap / PubMed) vs tissue (COSMIC primary tissue)
Total = all mutations for this gene across every source.
Cell line = COSMIC Cell Lines Project + DepMap + PubMed.
Tissue = COSMIC primary-tissue (patient tumour) samples.
Total can exceed cell line + tissue: COSMIC tissue-derived models sit only in global, and a peptide can be shared across both.
| Total | Cell line | Tissue | |
|---|---|---|---|
| Mutations | 625 | 78 | 541 |
| Samples | 335 | 40 | 292 |
| Peptides | 278 | 45 | 238 |
Function
PRR5-ARHGAP8 · PRR5-ARHGAP8 readthrough
The PRR5-ARHGAP8 mRNA is an infrequent but naturally occurring read-through transcript of the neighboring proline rich 5, renal (PRR5) and Rho GTPase activating protein 8 (ARHGAP8) genes. The resulting fusion protein contains sequence identity with each individual gene product, and it includes domains characteristic of a RhoGAP protein. The significance of this read-through transcript and the function of its protein product have not yet been determined. [provided by RefSeq, Nov 2010].
Isoforms & Proteins
2 transcripts · UniProt mapping is sequence-verified (AA-safe)
Each Ensembl transcript (ENST) this gene is mutated on, with its matched UniProt accession.
The mapping is sequence-verified: the UniProt sequence is identical to the transcript translation, so amino-acid positions line up exactly. A * marks an unreviewed (TrEMBL) entry.
Counts are mutations and unique mutant peptides on each transcript.
Gene Properties
Recurrent Mutations
All 246 amino-acid changes on canonical ENST00000352766 · needle height = samples · drag the mini-map to zoom
A lollipop / needle plot – the standard way to show recurrent mutations along a protein (as used by cBioPortal and MutationMapper).
X-axis = amino-acid position in the protein.
Needle height & head size = how often that exact amino-acid change was observed (its recurrence). Tall/large heads are mutational hotspots.
The most recurrent changes are labelled; hover any needle for the change, position and counts.
Mutation frequency across cancer types
% of samples with a missense/complex mutation in PRR5-ARHGAP8 · cell line vs tissue
For each cancer type, the fraction of samples that carry at least one missense/complex mutation anywhere in PRR5-ARHGAP8 – counted as distinct samples (a sample counts once no matter how many mutations it has).
Split into cell line and tissue; each cell shows mutated / total and the percentage. Cohorts with <20 samples are omitted. Ordered by combined frequency.
| Cancer type | Cell lines | Tissue samples |
|---|---|---|
| T-Lymphoblastic Leukemia | 3/40 8% | 0/0 0% |
| Chronic Myelogenous Leukemia | 1/25 4% | 0/0 0% |
| Melanoma | 3/210 1% | 49/1899 3% |
| Gastrointestinal Stromal Tumour | 0/0 0% | 3/133 2% |
| Hodgkins Lymphoma | 2/16 12% | 1/122 1% |
| Endometrial Carcinoma | 0/42 0% | 12/612 2% |
| Colorectal Carcinoma | 7/143 5% | 40/3239 1% |
| Cervical Carcinoma | 1/35 3% | 5/422 1% |
| Bladder Carcinoma | 1/58 2% | 12/956 1% |
| Squamous Cell Lung Carcinoma | 0/57 0% | 11/810 1% |
| Gastric Carcinoma | 2/74 3% | 21/1809 1% |
| Other Solid Cancers | 0/94 0% | 19/1515 1% |
| Acute Myeloid Leukemia | 1/90 1% | 0/0 0% |
| Glioblastoma | 1/98 1% | 0/0 0% |
| Non-Cancerous | 0/104 0% | 9/830 1% |
| Other Sarcomas | 2/69 3% | 5/699 1% |
| Hepatocellular Carcinoma | 0/46 0% | 20/2210 1% |
| Meningioma | 0/3 0% | 2/252 1% |
| Non-Small Cell Lung Carcinoma | 3/304 1% | 9/1390 1% |
| Neuroendocrine Tumour | 2/154 1% | 3/577 1% |
| Thyroid Gland Carcinoma | 0/45 0% | 11/1592 1% |
| Ovarian Carcinoma | 3/109 3% | 4/998 0% |
| Ewings Sarcoma | 0/63 0% | 2/262 1% |
| Glioma | 0/52 0% | 12/2127 1% |
| Germ Cell Tumour | 1/25 4% | 0/169 0% |
| Biliary Tract Carcinoma | 0/54 0% | 5/950 1% |
| Rhabdomyosarcoma | 1/33 3% | 0/171 0% |
| Esophageal Carcinoma | 0/23 0% | 3/769 0% |
| Neuroblastoma | 2/87 2% | 3/1331 0% |
| Esophageal Squamous Cell Carcinoma | 1/51 2% | 8/2550 0% |
Mutation Distribution
Where PRR5-ARHGAP8 is mutated · all tissues, split by cell line vs tissue
How many mutations in PRR5-ARHGAP8 were found in each tissue, across the whole database.
Each bar is a tissue (cell-line and tissue names are merged to the standard tissue), split into cell line and tissue (patient tumour) contributions.
This shows the cancer-context where this gene is recurrently altered.
Mutations
All 625 mutations in PRR5-ARHGAP8
Every mutation record for this gene, across all samples and sources.
The Sample column links to the cell line (cell-line samples) or the tissue type (tissue samples).
Use the Type / Source filters, the search box, and column sorting to explore; each CAN-IMMUNE ID opens the full mutation & peptide view.
| ID | Sample | Transcript | AA Change | CDS | Type | Source | Mutant Peptide | Wild-type Peptide |
|---|