Stats by Source
Total, split by cell line (COSMIC CL / DepMap / PubMed) vs tissue (COSMIC primary tissue)
Total = all mutations for this gene across every source.
Cell line = COSMIC Cell Lines Project + DepMap + PubMed.
Tissue = COSMIC primary-tissue (patient tumour) samples.
Total can exceed cell line + tissue: COSMIC tissue-derived models sit only in global, and a peptide can be shared across both.
| Total | Cell line | Tissue | |
|---|---|---|---|
| Mutations | 1,760 | 209 | 1,533 |
| Samples | 493 | 78 | 410 |
| Peptides | 381 | 58 | 331 |
Function
PTPN3 · Protein tyrosine phosphatase non-receptor type 3
The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This protein contains a C-terminal PTP domain and an N-terminal domain homologous to the band 4.1 superfamily of cytoskeletal-associated proteins. P97, a cell cycle regulator involved in a variety of membrane related functions, has been shown to be a substrate of this PTP. This PTP was also found to interact with, and be regulated by adaptor protein 14-3-3 beta. Several alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2009].
Isoforms & Proteins
4 transcripts · UniProt mapping is sequence-verified (AA-safe)
Each Ensembl transcript (ENST) this gene is mutated on, with its matched UniProt accession.
The mapping is sequence-verified: the UniProt sequence is identical to the transcript translation, so amino-acid positions line up exactly. A * marks an unreviewed (TrEMBL) entry.
Counts are mutations and unique mutant peptides on each transcript.
Gene Properties
Recurrent Mutations
All 360 amino-acid changes on canonical ENST00000374541 · needle height = samples · drag the mini-map to zoom
A lollipop / needle plot – the standard way to show recurrent mutations along a protein (as used by cBioPortal and MutationMapper).
X-axis = amino-acid position in the protein.
Needle height & head size = how often that exact amino-acid change was observed (its recurrence). Tall/large heads are mutational hotspots.
The most recurrent changes are labelled; hover any needle for the change, position and counts.
Mutation frequency across cancer types
% of samples with a missense/complex mutation in PTPN3 · cell line vs tissue
For each cancer type, the fraction of samples that carry at least one missense/complex mutation anywhere in PTPN3 – counted as distinct samples (a sample counts once no matter how many mutations it has).
Split into cell line and tissue; each cell shows mutated / total and the percentage. Cohorts with <20 samples are omitted. Ordered by combined frequency.
| Cancer type | Cell lines | Tissue samples |
|---|---|---|
| Endometrial Carcinoma | 6/42 14% | 24/612 4% |
| Rhabdomyosarcoma | 0/33 0% | 6/171 4% |
| Melanoma | 5/210 2% | 54/1899 3% |
| T-Lymphoblastic Leukemia | 1/40 2% | 0/0 0% |
| Gastric Carcinoma | 4/74 5% | 38/1809 2% |
| Hodgkins Lymphoma | 2/16 12% | 1/122 1% |
| Colorectal Carcinoma | 13/143 9% | 59/3239 2% |
| Squamous Cell Lung Carcinoma | 5/57 9% | 13/810 2% |
| Non-Small Cell Lung Carcinoma | 11/304 4% | 19/1390 1% |
| Osteosarcoma | 3/45 7% | 0/166 0% |
| Bladder Carcinoma | 2/58 3% | 11/956 1% |
| Hepatocellular Carcinoma | 1/46 2% | 25/2210 1% |
| Acute Myeloid Leukemia | 1/90 1% | 0/0 0% |
| Neuroendocrine Tumour | 1/154 1% | 7/577 1% |
| Other Solid Cancers | 0/94 0% | 17/1515 1% |
| Glioblastoma | 1/98 1% | 0/0 0% |
| Glioma | 1/52 2% | 20/2127 1% |
| Non-Cancerous | 1/104 1% | 8/830 1% |
| Ovarian Carcinoma | 2/109 2% | 8/998 1% |
| Adrenocortical Carcinoma | 0/3 0% | 1/112 1% |
| Meningioma | 0/3 0% | 2/252 1% |
| Pancreatic Carcinoma | 2/89 2% | 11/1611 1% |
| Gastrointestinal Stromal Tumour | 0/0 0% | 1/133 1% |
| Head and Neck Carcinoma | 2/85 2% | 10/1574 1% |
| Esophageal Squamous Cell Carcinoma | 0/51 0% | 17/2550 1% |
| Ewings Sarcoma | 0/63 0% | 2/262 1% |
| Plasma Cell Myeloma | 0/44 0% | 2/305 1% |
| Breast Carcinoma | 5/144 3% | 12/3264 0% |
| Biliary Tract Carcinoma | 1/54 2% | 4/950 0% |
| Thyroid Gland Carcinoma | 0/45 0% | 8/1592 0% |
Mutation Distribution
Where PTPN3 is mutated · all tissues, split by cell line vs tissue
How many mutations in PTPN3 were found in each tissue, across the whole database.
Each bar is a tissue (cell-line and tissue names are merged to the standard tissue), split into cell line and tissue (patient tumour) contributions.
This shows the cancer-context where this gene is recurrently altered.
GTEx Expression
Median TPM across 54 healthy tissues
Median gene expression (TPM) in normal, non-cancer human tissues from the GTEx project.
Useful for judging tumour specificity – a strong neoantigen target ideally comes from a gene with low expression in healthy tissues.
Scroll or drag the mini-axis below the chart to browse all tissues.
Mutations
All 1,760 mutations in PTPN3
Every mutation record for this gene, across all samples and sources.
The Sample column links to the cell line (cell-line samples) or the tissue type (tissue samples).
Use the Type / Source filters, the search box, and column sorting to explore; each CAN-IMMUNE ID opens the full mutation & peptide view.
| ID | Sample | Transcript | AA Change | CDS | Type | Source | Mutant Peptide | Wild-type Peptide |
|---|