Stats by Source
Total, split by cell line (COSMIC CL / DepMap / PubMed) vs tissue (COSMIC primary tissue)
Total = all mutations for this gene across every source.
Cell line = COSMIC Cell Lines Project + DepMap + PubMed.
Tissue = COSMIC primary-tissue (patient tumour) samples.
Total can exceed cell line + tissue: COSMIC tissue-derived models sit only in global, and a peptide can be shared across both.
| Total | Cell line | Tissue | |
|---|---|---|---|
| Mutations | 2,095 | 300 | 1,764 |
| Samples | 1,043 | 180 | 843 |
| Peptides | 830 | 135 | 718 |
Function
PTPRC · Protein tyrosine phosphatase receptor type C
The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitosis, and oncogenic transformation. This PTP contains an extracellular domain, a single transmembrane segment and two tandem intracytoplasmic catalytic domains, and thus is classified as a receptor type PTP. This PTP has been shown to be an essential regulator of T- and B-cell antigen receptor signaling. It functions through either direct interaction with components of the antigen receptor complexes, or by activating various Src family kinases required for the antigen receptor signaling. This PTP also suppresses JAK kinases, and thus functions as a regulator of cytokine receptor signaling. Alternatively spliced transcripts variants of this gene, which encode distinct isoforms, have been reported. [provided by RefSeq, Jun 2012].
Isoforms & Proteins
4 transcripts · UniProt mapping is sequence-verified (AA-safe)
Each Ensembl transcript (ENST) this gene is mutated on, with its matched UniProt accession.
The mapping is sequence-verified: the UniProt sequence is identical to the transcript translation, so amino-acid positions line up exactly. A * marks an unreviewed (TrEMBL) entry.
Counts are mutations and unique mutant peptides on each transcript.
Gene Properties
Recurrent Mutations
All 794 amino-acid changes on canonical ENST00000442510 · needle height = samples · drag the mini-map to zoom
A lollipop / needle plot – the standard way to show recurrent mutations along a protein (as used by cBioPortal and MutationMapper).
X-axis = amino-acid position in the protein.
Needle height & head size = how often that exact amino-acid change was observed (its recurrence). Tall/large heads are mutational hotspots.
The most recurrent changes are labelled; hover any needle for the change, position and counts.
Mutation frequency across cancer types
% of samples with a missense/complex mutation in PTPRC · cell line vs tissue
For each cancer type, the fraction of samples that carry at least one missense/complex mutation anywhere in PTPRC – counted as distinct samples (a sample counts once no matter how many mutations it has).
Split into cell line and tissue; each cell shows mutated / total and the percentage. Cohorts with <20 samples are omitted. Ordered by combined frequency.
| Cancer type | Cell lines | Tissue samples |
|---|---|---|
| T-Lymphoblastic Leukemia | 7/40 18% | 0/0 0% |
| Oral Cavity Carcinoma | 6/54 11% | 0/0 0% |
| Melanoma | 13/210 6% | 159/1899 8% |
| Glioblastoma | 7/98 7% | 0/0 0% |
| Endometrial Carcinoma | 7/42 17% | 31/612 5% |
| Squamous Cell Lung Carcinoma | 4/57 7% | 38/810 5% |
| Non-Small Cell Lung Carcinoma | 22/304 7% | 58/1390 4% |
| Other Solid Cancers | 6/94 6% | 56/1515 4% |
| Gastric Carcinoma | 1/74 1% | 70/1809 4% |
| Small Cell Lung Carcinoma | 0/9 0% | 26/752 3% |
| Acute Myeloid Leukemia | 3/90 3% | 0/0 0% |
| Colorectal Carcinoma | 18/143 13% | 93/3239 3% |
| Hodgkins Lymphoma | 2/16 12% | 2/122 2% |
| Neuroendocrine Tumour | 9/154 6% | 10/577 2% |
| Bladder Carcinoma | 4/58 7% | 22/956 2% |
| Cervical Carcinoma | 3/35 9% | 7/422 2% |
| Hepatocellular Carcinoma | 5/46 11% | 42/2210 2% |
| Other Sarcomas | 5/69 7% | 9/699 1% |
| Head and Neck Carcinoma | 3/85 4% | 27/1574 2% |
| Esophageal Squamous Cell Carcinoma | 1/51 2% | 46/2550 2% |
| Ovarian Carcinoma | 9/109 8% | 10/998 1% |
| Ewings Sarcoma | 3/63 5% | 2/262 1% |
| Biliary Tract Carcinoma | 2/54 4% | 12/950 1% |
| Burkitts Lymphoma | 1/32 3% | 2/196 1% |
| Esophageal Carcinoma | 0/23 0% | 10/769 1% |
| Prostate Carcinoma | 3/13 23% | 22/2105 1% |
| Plasma Cell Myeloma | 1/44 2% | 3/305 1% |
| Breast Carcinoma | 11/144 8% | 26/3264 1% |
| Germ Cell Tumour | 0/25 0% | 2/169 1% |
| Osteosarcoma | 1/45 2% | 1/166 1% |
Mutation Distribution
Where PTPRC is mutated · all tissues, split by cell line vs tissue
How many mutations in PTPRC were found in each tissue, across the whole database.
Each bar is a tissue (cell-line and tissue names are merged to the standard tissue), split into cell line and tissue (patient tumour) contributions.
This shows the cancer-context where this gene is recurrently altered.
GTEx Expression
Median TPM across 54 healthy tissues
Median gene expression (TPM) in normal, non-cancer human tissues from the GTEx project.
Useful for judging tumour specificity – a strong neoantigen target ideally comes from a gene with low expression in healthy tissues.
Scroll or drag the mini-axis below the chart to browse all tissues.
Mutations
All 2,095 mutations in PTPRC
Every mutation record for this gene, across all samples and sources.
The Sample column links to the cell line (cell-line samples) or the tissue type (tissue samples).
Use the Type / Source filters, the search box, and column sorting to explore; each CAN-IMMUNE ID opens the full mutation & peptide view.
| ID | Sample | Transcript | AA Change | CDS | Type | Source | Mutant Peptide | Wild-type Peptide |
|---|