Stats by Source
Total, split by cell line (COSMIC CL / DepMap / PubMed) vs tissue (COSMIC primary tissue)
Total = all mutations for this gene across every source.
Cell line = COSMIC Cell Lines Project + DepMap + PubMed.
Tissue = COSMIC primary-tissue (patient tumour) samples.
Total can exceed cell line + tissue: COSMIC tissue-derived models sit only in global, and a peptide can be shared across both.
| Total | Cell line | Tissue | |
|---|---|---|---|
| Mutations | 5,360 | 660 | 4,612 |
| Samples | 864 | 175 | 673 |
| Peptides | 751 | 132 | 629 |
Function
PTPRK · Protein tyrosine phosphatase receptor type K
The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP possesses an extracellular region, a single transmembrane region, and two tandem catalytic domains, and thus represents a receptor-type PTP. The extracellular region contains a meprin-A5 antigen-PTP mu (MAM) domain, an Ig-like domain and four fibronectin type III-like repeats. This PTP was shown to mediate homophilic intercellular interaction, possibly through the interaction with beta- and gamma-catenin at adherens junctions. Expression of this gene was found to be stimulated by TGF-beta 1, which may be important for the inhibition of keratinocyte proliferation. [provided by RefSeq, Jul 2008].
Isoforms & Proteins
9 transcripts · UniProt mapping is sequence-verified (AA-safe)
Each Ensembl transcript (ENST) this gene is mutated on, with its matched UniProt accession.
The mapping is sequence-verified: the UniProt sequence is identical to the transcript translation, so amino-acid positions line up exactly. A * marks an unreviewed (TrEMBL) entry.
Counts are mutations and unique mutant peptides on each transcript.
| Transcript | UniProt | Mutations | Peptides |
|---|---|---|---|
| ENST00000368226 | Q15262-2 | 967 | 680 |
| ENST00000368207 | E9PGC5* | 863 | 650 |
| ENST00000532331 | Q15262-4 | 859 | 646 |
| ENST00000368210 | Q5TG12* | 858 | 645 |
| ENST00000368213 | Q15262-3 | 857 | 644 |
| ENST00000368215 | Q15262 | 856 | 643 |
| ENST00000525459 | E9PRW2* | 95 | 74 |
| ENST00000628183 | Q15262 | 3 | 3 |
| ENST00000618924 | Q15262-2 | 2 | 2 |
Gene Properties
Recurrent Mutations
All 680 amino-acid changes on canonical ENST00000368226 · needle height = samples · drag the mini-map to zoom
A lollipop / needle plot – the standard way to show recurrent mutations along a protein (as used by cBioPortal and MutationMapper).
X-axis = amino-acid position in the protein.
Needle height & head size = how often that exact amino-acid change was observed (its recurrence). Tall/large heads are mutational hotspots.
The most recurrent changes are labelled; hover any needle for the change, position and counts.
Mutation frequency across cancer types
% of samples with a missense/complex mutation in PTPRK · cell line vs tissue
For each cancer type, the fraction of samples that carry at least one missense/complex mutation anywhere in PTPRK – counted as distinct samples (a sample counts once no matter how many mutations it has).
Split into cell line and tissue; each cell shows mutated / total and the percentage. Cohorts with <20 samples are omitted. Ordered by combined frequency.
| Cancer type | Cell lines | Tissue samples |
|---|---|---|
| T-Lymphoblastic Leukemia | 7/40 18% | 0/0 0% |
| Melanoma | 26/210 12% | 182/1899 10% |
| Chronic Myelogenous Leukemia | 2/25 8% | 0/0 0% |
| Glioblastoma | 7/98 7% | 0/0 0% |
| Endometrial Carcinoma | 12/42 29% | 32/612 5% |
| Oral Cavity Carcinoma | 2/54 4% | 0/0 0% |
| Colorectal Carcinoma | 21/143 15% | 100/3239 3% |
| Squamous Cell Lung Carcinoma | 3/57 5% | 21/810 3% |
| Non-Small Cell Lung Carcinoma | 12/304 4% | 34/1390 2% |
| Neuroendocrine Tumour | 11/154 7% | 8/577 1% |
| Bladder Carcinoma | 2/58 3% | 22/956 2% |
| Other Sarcomas | 6/69 9% | 12/699 2% |
| Gastric Carcinoma | 3/74 4% | 39/1809 2% |
| Acute Myeloid Leukemia | 2/90 2% | 0/0 0% |
| Cervical Carcinoma | 0/35 0% | 9/422 2% |
| Osteosarcoma | 3/45 7% | 1/166 1% |
| Other Solid Cancers | 0/94 0% | 25/1515 2% |
| Hodgkins Lymphoma | 2/16 12% | 0/122 0% |
| Pheochromocytoma and Paraganglioma | 0/0 0% | 1/71 1% |
| Esophageal Squamous Cell Carcinoma | 3/51 6% | 32/2550 1% |
| Non-Cancerous | 2/104 2% | 9/830 1% |
| Ovarian Carcinoma | 4/109 4% | 8/998 1% |
| Small Cell Lung Carcinoma | 0/9 0% | 8/752 1% |
| Germ Cell Tumour | 2/25 8% | 0/169 0% |
| Hepatocellular Carcinoma | 1/46 2% | 22/2210 1% |
| Esophageal Carcinoma | 2/23 9% | 6/769 1% |
| Glioma | 1/52 2% | 20/2127 1% |
| Prostate Carcinoma | 3/13 23% | 17/2105 1% |
| Head and Neck Carcinoma | 0/85 0% | 15/1574 1% |
| Kidney Carcinoma | 5/85 6% | 10/1862 1% |
Mutation Distribution
Where PTPRK is mutated · all tissues, split by cell line vs tissue
How many mutations in PTPRK were found in each tissue, across the whole database.
Each bar is a tissue (cell-line and tissue names are merged to the standard tissue), split into cell line and tissue (patient tumour) contributions.
This shows the cancer-context where this gene is recurrently altered.
GTEx Expression
Median TPM across 54 healthy tissues
Median gene expression (TPM) in normal, non-cancer human tissues from the GTEx project.
Useful for judging tumour specificity – a strong neoantigen target ideally comes from a gene with low expression in healthy tissues.
Scroll or drag the mini-axis below the chart to browse all tissues.
Mutations
All 5,360 mutations in PTPRK
Every mutation record for this gene, across all samples and sources.
The Sample column links to the cell line (cell-line samples) or the tissue type (tissue samples).
Use the Type / Source filters, the search box, and column sorting to explore; each CAN-IMMUNE ID opens the full mutation & peptide view.
| ID | Sample | Transcript | AA Change | CDS | Type | Source | Mutant Peptide | Wild-type Peptide |
|---|