Stats by Source
Total, split by cell line (COSMIC CL / DepMap / PubMed) vs tissue (COSMIC primary tissue)
Total = all mutations for this gene across every source.
Cell line = COSMIC Cell Lines Project + DepMap + PubMed.
Tissue = COSMIC primary-tissue (patient tumour) samples.
Total can exceed cell line + tissue: COSMIC tissue-derived models sit only in global, and a peptide can be shared across both.
| Total | Cell line | Tissue | |
|---|---|---|---|
| Mutations | 591 | 97 | 487 |
| Samples | 524 | 81 | 440 |
| Peptides | 437 | 66 | 374 |
Function
RAB3GAP2 · RAB3 GTPase activating non-catalytic protein subunit 2
The protein encoded by this gene belongs to the RAB3 protein family, members of which are involved in regulated exocytosis of neurotransmitters and hormones. This protein forms the Rab3 GTPase-activating complex with RAB3GAP1, where it constitutes the regulatory subunit, whereas the latter functions as the catalytic subunit. This gene has the highest level of expression in the brain, consistent with it having a key role in neurodevelopment. Mutations in this gene are associated with Martsolf syndrome.[provided by RefSeq, Oct 2009].
Isoforms & Proteins
1 transcript · UniProt mapping is sequence-verified (AA-safe)
Each Ensembl transcript (ENST) this gene is mutated on, with its matched UniProt accession.
The mapping is sequence-verified: the UniProt sequence is identical to the transcript translation, so amino-acid positions line up exactly. A * marks an unreviewed (TrEMBL) entry.
Counts are mutations and unique mutant peptides on each transcript.
| Transcript | UniProt | Mutations | Peptides |
|---|---|---|---|
| ENST00000358951 | Q9H2M9 | 591 | 437 |
Gene Properties
Recurrent Mutations
All 437 amino-acid changes on canonical ENST00000358951 · needle height = samples · drag the mini-map to zoom
A lollipop / needle plot – the standard way to show recurrent mutations along a protein (as used by cBioPortal and MutationMapper).
X-axis = amino-acid position in the protein.
Needle height & head size = how often that exact amino-acid change was observed (its recurrence). Tall/large heads are mutational hotspots.
The most recurrent changes are labelled; hover any needle for the change, position and counts.
Mutation frequency across cancer types
% of samples with a missense/complex mutation in RAB3GAP2 · cell line vs tissue
For each cancer type, the fraction of samples that carry at least one missense/complex mutation anywhere in RAB3GAP2 – counted as distinct samples (a sample counts once no matter how many mutations it has).
Split into cell line and tissue; each cell shows mutated / total and the percentage. Cohorts with <20 samples are omitted. Ordered by combined frequency.
| Cancer type | Cell lines | Tissue samples |
|---|---|---|
| T-Lymphoblastic Leukemia | 6/40 15% | 0/0 0% |
| Endometrial Carcinoma | 4/42 10% | 33/612 5% |
| Chordoma | 0/7 0% | 1/13 8% |
| T-Cell Non-Hodgkins Lymphoma | 1/26 4% | 0/0 0% |
| Acute Monocytic Leukemia | 0/1 0% | 1/25 4% |
| Acute Myeloid Leukemia | 3/90 3% | 0/0 0% |
| Melanoma | 4/210 2% | 49/1899 3% |
| Non-Small Cell Lung Carcinoma | 11/304 4% | 27/1390 2% |
| Colorectal Carcinoma | 13/143 9% | 57/3239 2% |
| Glioblastoma | 2/98 2% | 0/0 0% |
| Other Solid Cancers | 3/94 3% | 29/1515 2% |
| Gastric Carcinoma | 4/74 5% | 31/1809 2% |
| Oral Cavity Carcinoma | 1/54 2% | 0/0 0% |
| Squamous Cell Lung Carcinoma | 0/57 0% | 16/810 2% |
| Bladder Carcinoma | 2/58 3% | 13/956 1% |
| Hodgkins Lymphoma | 0/16 0% | 2/122 2% |
| Mesothelioma | 3/62 5% | 0/165 0% |
| Chondrosarcoma | 0/14 0% | 1/75 1% |
| Thyroid Gland Carcinoma | 0/45 0% | 18/1592 1% |
| Esophageal Squamous Cell Carcinoma | 4/51 8% | 24/2550 1% |
| Glioma | 1/52 2% | 21/2127 1% |
| Neuroendocrine Tumour | 3/154 2% | 4/577 1% |
| Ewings Sarcoma | 2/63 3% | 1/262 0% |
| Hepatocellular Carcinoma | 1/46 2% | 19/2210 1% |
| Cervical Carcinoma | 0/35 0% | 4/422 1% |
| Burkitts Lymphoma | 0/32 0% | 2/196 1% |
| Biliary Tract Carcinoma | 0/54 0% | 8/950 1% |
| Small Cell Lung Carcinoma | 0/9 0% | 5/752 1% |
| Esophageal Carcinoma | 0/23 0% | 5/769 1% |
| Breast Carcinoma | 3/144 2% | 18/3264 1% |
Mutation Distribution
Where RAB3GAP2 is mutated · all tissues, split by cell line vs tissue
How many mutations in RAB3GAP2 were found in each tissue, across the whole database.
Each bar is a tissue (cell-line and tissue names are merged to the standard tissue), split into cell line and tissue (patient tumour) contributions.
This shows the cancer-context where this gene is recurrently altered.
GTEx Expression
Median TPM across 54 healthy tissues
Median gene expression (TPM) in normal, non-cancer human tissues from the GTEx project.
Useful for judging tumour specificity – a strong neoantigen target ideally comes from a gene with low expression in healthy tissues.
Scroll or drag the mini-axis below the chart to browse all tissues.
Mutations
All 591 mutations in RAB3GAP2
Every mutation record for this gene, across all samples and sources.
The Sample column links to the cell line (cell-line samples) or the tissue type (tissue samples).
Use the Type / Source filters, the search box, and column sorting to explore; each CAN-IMMUNE ID opens the full mutation & peptide view.
| ID | Sample | Transcript | AA Change | CDS | Type | Source | Mutant Peptide | Wild-type Peptide |
|---|