Stats by Source
Total, split by cell line (COSMIC CL / DepMap / PubMed) vs tissue (COSMIC primary tissue)
Total = all mutations for this gene across every source.
Cell line = COSMIC Cell Lines Project + DepMap + PubMed.
Tissue = COSMIC primary-tissue (patient tumour) samples.
Total can exceed cell line + tissue: COSMIC tissue-derived models sit only in global, and a peptide can be shared across both.
| Total | Cell line | Tissue | |
|---|---|---|---|
| Mutations | 1,340 | 208 | 1,122 |
| Samples | 351 | 74 | 273 |
| Peptides | 315 | 55 | 265 |
Function
RBBP8 · RB binding protein 8, endonuclease
The protein encoded by this gene is a ubiquitously expressed nuclear protein. It is found among several proteins that bind directly to retinoblastoma protein, which regulates cell proliferation. This protein complexes with transcriptional co-repressor CTBP. It is also associated with BRCA1 and is thought to modulate the functions of BRCA1 in transcriptional regulation, DNA repair, and/or cell cycle checkpoint control. It is suggested that this gene may itself be a tumor suppressor acting in the same pathway as BRCA1. Three transcript variants encoding two different isoforms have been found for this gene. More transcript variants exist, but their full-length natures have not been determined. [provided by RefSeq, Jul 2008].
Isoforms & Proteins
5 transcripts · UniProt mapping is sequence-verified (AA-safe)
Each Ensembl transcript (ENST) this gene is mutated on, with its matched UniProt accession.
The mapping is sequence-verified: the UniProt sequence is identical to the transcript translation, so amino-acid positions line up exactly. A * marks an unreviewed (TrEMBL) entry.
Counts are mutations and unique mutant peptides on each transcript.
Gene Properties
Recurrent Mutations
All 283 amino-acid changes on canonical ENST00000327155 · needle height = samples · drag the mini-map to zoom
A lollipop / needle plot – the standard way to show recurrent mutations along a protein (as used by cBioPortal and MutationMapper).
X-axis = amino-acid position in the protein.
Needle height & head size = how often that exact amino-acid change was observed (its recurrence). Tall/large heads are mutational hotspots.
The most recurrent changes are labelled; hover any needle for the change, position and counts.
Mutation frequency across cancer types
% of samples with a missense/complex mutation in RBBP8 · cell line vs tissue
For each cancer type, the fraction of samples that carry at least one missense/complex mutation anywhere in RBBP8 – counted as distinct samples (a sample counts once no matter how many mutations it has).
Split into cell line and tissue; each cell shows mutated / total and the percentage. Cohorts with <20 samples are omitted. Ordered by combined frequency.
| Cancer type | Cell lines | Tissue samples |
|---|---|---|
| Chronic Myelogenous Leukemia | 2/25 8% | 0/0 0% |
| T-Lymphoblastic Leukemia | 2/40 5% | 0/0 0% |
| Acute Myeloid Leukemia | 4/90 4% | 0/0 0% |
| T-Cell Non-Hodgkins Lymphoma | 1/26 4% | 0/0 0% |
| Endometrial Carcinoma | 3/42 7% | 19/612 3% |
| Thymic Epithelial Tumor | 0/0 0% | 1/39 3% |
| Melanoma | 5/210 2% | 33/1899 2% |
| Colorectal Carcinoma | 14/143 10% | 43/3239 1% |
| Bladder Carcinoma | 0/58 0% | 15/956 2% |
| Pheochromocytoma and Paraganglioma | 0/0 0% | 1/71 1% |
| Cervical Carcinoma | 2/35 6% | 4/422 1% |
| Biliary Tract Carcinoma | 2/54 4% | 10/950 1% |
| Non-Small Cell Lung Carcinoma | 8/304 3% | 12/1390 1% |
| Glioblastoma | 1/98 1% | 0/0 0% |
| Gastric Carcinoma | 1/74 1% | 16/1809 1% |
| Other Solid Cancers | 3/94 3% | 11/1515 1% |
| Plasma Cell Myeloma | 1/44 2% | 2/305 1% |
| Ovarian Carcinoma | 4/109 4% | 5/998 0% |
| Esophageal Carcinoma | 2/23 9% | 4/769 1% |
| Hepatocellular Carcinoma | 0/46 0% | 17/2210 1% |
| Squamous Cell Lung Carcinoma | 1/57 2% | 5/810 1% |
| Esophageal Squamous Cell Carcinoma | 2/51 4% | 16/2550 1% |
| Head and Neck Carcinoma | 1/85 1% | 10/1574 1% |
| Neuroendocrine Tumour | 1/154 1% | 3/577 1% |
| Other Sarcomas | 0/69 0% | 4/699 1% |
| Germ Cell Tumour | 0/25 0% | 1/169 1% |
| Burkitts Lymphoma | 0/32 0% | 1/196 1% |
| Glioma | 4/52 8% | 5/2127 0% |
| Small Cell Lung Carcinoma | 0/9 0% | 3/752 0% |
| Breast Carcinoma | 2/144 1% | 11/3264 0% |
Mutation Distribution
Where RBBP8 is mutated · all tissues, split by cell line vs tissue
How many mutations in RBBP8 were found in each tissue, across the whole database.
Each bar is a tissue (cell-line and tissue names are merged to the standard tissue), split into cell line and tissue (patient tumour) contributions.
This shows the cancer-context where this gene is recurrently altered.
GTEx Expression
Median TPM across 54 healthy tissues
Median gene expression (TPM) in normal, non-cancer human tissues from the GTEx project.
Useful for judging tumour specificity – a strong neoantigen target ideally comes from a gene with low expression in healthy tissues.
Scroll or drag the mini-axis below the chart to browse all tissues.
Mutations
All 1,340 mutations in RBBP8
Every mutation record for this gene, across all samples and sources.
The Sample column links to the cell line (cell-line samples) or the tissue type (tissue samples).
Use the Type / Source filters, the search box, and column sorting to explore; each CAN-IMMUNE ID opens the full mutation & peptide view.
| ID | Sample | Transcript | AA Change | CDS | Type | Source | Mutant Peptide | Wild-type Peptide |
|---|