Stats by Source
Total, split by cell line (COSMIC CL / DepMap / PubMed) vs tissue (COSMIC primary tissue)
Total = all mutations for this gene across every source.
Cell line = COSMIC Cell Lines Project + DepMap + PubMed.
Tissue = COSMIC primary-tissue (patient tumour) samples.
Total can exceed cell line + tissue: COSMIC tissue-derived models sit only in global, and a peptide can be shared across both.
| Total | Cell line | Tissue | |
|---|---|---|---|
| Mutations | 286 | 63 | 223 |
| Samples | 273 | 57 | 216 |
| Peptides | 184 | 35 | 161 |
Function
REG1B · Regenerating family member 1 beta
This gene is a type I subclass member of the Reg gene family. The Reg gene family is a multigene family grouped into four subclasses, types I, II, III and IV based on the primary structures of the encoded proteins. This gene encodes a protein secreted by the exocrine pancreas that is highly similar to the REG1A protein. The related REG1A protein is associated with islet cell regeneration and diabetogenesis, and may be involved in pancreatic lithogenesis. Reg family members REG1A, REGL, PAP and this gene are tandemly clustered on chromosome 2p12 and may have arisen from the same ancestral gene by gene duplication. [provided by RefSeq, Jul 2008].
Isoforms & Proteins
1 transcript · UniProt mapping is sequence-verified (AA-safe)
Each Ensembl transcript (ENST) this gene is mutated on, with its matched UniProt accession.
The mapping is sequence-verified: the UniProt sequence is identical to the transcript translation, so amino-acid positions line up exactly. A * marks an unreviewed (TrEMBL) entry.
Counts are mutations and unique mutant peptides on each transcript.
| Transcript | UniProt | Mutations | Peptides |
|---|---|---|---|
| ENST00000305089 | P48304 | 286 | 184 |
Gene Properties
Recurrent Mutations
All 184 amino-acid changes on canonical ENST00000305089 · needle height = samples · drag the mini-map to zoom
A lollipop / needle plot – the standard way to show recurrent mutations along a protein (as used by cBioPortal and MutationMapper).
X-axis = amino-acid position in the protein.
Needle height & head size = how often that exact amino-acid change was observed (its recurrence). Tall/large heads are mutational hotspots.
The most recurrent changes are labelled; hover any needle for the change, position and counts.
Mutation frequency across cancer types
% of samples with a missense/complex mutation in REG1B · cell line vs tissue
For each cancer type, the fraction of samples that carry at least one missense/complex mutation anywhere in REG1B – counted as distinct samples (a sample counts once no matter how many mutations it has).
Split into cell line and tissue; each cell shows mutated / total and the percentage. Cohorts with <20 samples are omitted. Ordered by combined frequency.
| Cancer type | Cell lines | Tissue samples |
|---|---|---|
| T-Lymphoblastic Leukemia | 2/40 5% | 0/0 0% |
| Squamous Cell Lung Carcinoma | 2/57 4% | 26/810 3% |
| Non-Small Cell Lung Carcinoma | 18/304 6% | 36/1390 3% |
| Small Cell Lung Carcinoma | 0/9 0% | 16/752 2% |
| Adrenocortical Carcinoma | 2/3 67% | 0/112 0% |
| Melanoma | 5/210 2% | 28/1899 1% |
| Hodgkins Lymphoma | 2/16 12% | 0/122 0% |
| Burkitts Lymphoma | 3/32 9% | 0/196 0% |
| Endometrial Carcinoma | 1/42 2% | 6/612 1% |
| Neuroendocrine Tumour | 4/154 3% | 3/577 1% |
| Bladder Carcinoma | 2/58 3% | 6/956 1% |
| Head and Neck Carcinoma | 0/85 0% | 12/1574 1% |
| Other Solid Cancers | 2/94 2% | 9/1515 1% |
| Gastric Carcinoma | 0/74 0% | 12/1809 1% |
| Esophageal Carcinoma | 0/23 0% | 4/769 1% |
| Cervical Carcinoma | 0/35 0% | 2/422 0% |
| Colorectal Carcinoma | 5/143 4% | 8/3239 0% |
| Esophageal Squamous Cell Carcinoma | 2/51 4% | 7/2550 0% |
| Breast Carcinoma | 1/144 1% | 10/3264 0% |
| Hepatocellular Carcinoma | 0/46 0% | 7/2210 0% |
| Glioma | 0/52 0% | 6/2127 0% |
| Ovarian Carcinoma | 2/109 2% | 1/998 0% |
| B-Cell Non-Hodgkins Lymphoma | 1/88 1% | 6/2534 0% |
| Other Sarcomas | 0/69 0% | 2/699 0% |
| Biliary Tract Carcinoma | 1/54 2% | 1/950 0% |
| Thyroid Gland Carcinoma | 0/45 0% | 3/1592 0% |
| Pancreatic Carcinoma | 0/89 0% | 2/1611 0% |
| Kidney Carcinoma | 1/85 1% | 1/1862 0% |
| Prostate Carcinoma | 0/13 0% | 2/2105 0% |
| B-Lymphoblastic Leukemia | 1/55 2% | 0/2640 0% |
Mutation Distribution
Where REG1B is mutated · all tissues, split by cell line vs tissue
How many mutations in REG1B were found in each tissue, across the whole database.
Each bar is a tissue (cell-line and tissue names are merged to the standard tissue), split into cell line and tissue (patient tumour) contributions.
This shows the cancer-context where this gene is recurrently altered.
GTEx Expression
Median TPM across 54 healthy tissues
Median gene expression (TPM) in normal, non-cancer human tissues from the GTEx project.
Useful for judging tumour specificity – a strong neoantigen target ideally comes from a gene with low expression in healthy tissues.
Scroll or drag the mini-axis below the chart to browse all tissues.
Mutations
All 286 mutations in REG1B
Every mutation record for this gene, across all samples and sources.
The Sample column links to the cell line (cell-line samples) or the tissue type (tissue samples).
Use the Type / Source filters, the search box, and column sorting to explore; each CAN-IMMUNE ID opens the full mutation & peptide view.
| ID | Sample | Transcript | AA Change | CDS | Type | Source | Mutant Peptide | Wild-type Peptide |
|---|