Stats by Source
Total, split by cell line (COSMIC CL / DepMap / PubMed) vs tissue (COSMIC primary tissue)
Total = all mutations for this gene across every source.
Cell line = COSMIC Cell Lines Project + DepMap + PubMed.
Tissue = COSMIC primary-tissue (patient tumour) samples.
Total can exceed cell line + tissue: COSMIC tissue-derived models sit only in global, and a peptide can be shared across both.
| Total | Cell line | Tissue | |
|---|---|---|---|
| Mutations | 142 | 48 | 88 |
| Samples | 77 | 39 | 36 |
| Peptides | 44 | 10 | 33 |
Function
RETN · Resistin
This gene belongs to the family defined by the mouse resistin-like genes. The characteristic feature of this family is the C-terminal stretch of 10 cys residues with identical spacing. The mouse homolog of this protein is secreted by adipocytes, and may be the hormone potentially linking obesity to type II diabetes. The encoded protein also has an antimicrobial role in skin, displaying antibacterial activity against both Gram positive and Gram negative bacteria. Alternatively spliced transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2020].
Isoforms & Proteins
3 transcripts · UniProt mapping is sequence-verified (AA-safe)
Each Ensembl transcript (ENST) this gene is mutated on, with its matched UniProt accession.
The mapping is sequence-verified: the UniProt sequence is identical to the transcript translation, so amino-acid positions line up exactly. A * marks an unreviewed (TrEMBL) entry.
Counts are mutations and unique mutant peptides on each transcript.
Gene Properties
Recurrent Mutations
All 36 amino-acid changes on canonical ENST00000221515 · needle height = samples · drag the mini-map to zoom
A lollipop / needle plot – the standard way to show recurrent mutations along a protein (as used by cBioPortal and MutationMapper).
X-axis = amino-acid position in the protein.
Needle height & head size = how often that exact amino-acid change was observed (its recurrence). Tall/large heads are mutational hotspots.
The most recurrent changes are labelled; hover any needle for the change, position and counts.
Mutation frequency across cancer types
% of samples with a missense/complex mutation in RETN · cell line vs tissue
For each cancer type, the fraction of samples that carry at least one missense/complex mutation anywhere in RETN – counted as distinct samples (a sample counts once no matter how many mutations it has).
Split into cell line and tissue; each cell shows mutated / total and the percentage. Cohorts with <20 samples are omitted. Ordered by combined frequency.
| Cancer type | Cell lines | Tissue samples |
|---|---|---|
| T-Lymphoblastic Leukemia | 2/40 5% | 0/0 0% |
| T-Cell Non-Hodgkins Lymphoma | 1/26 4% | 0/0 0% |
| Oral Cavity Carcinoma | 2/54 4% | 0/0 0% |
| Osteosarcoma | 3/45 7% | 0/166 0% |
| Chondrosarcoma | 1/14 7% | 0/75 0% |
| Neuroendocrine Tumour | 3/154 2% | 1/577 0% |
| Germ Cell Tumour | 0/25 0% | 1/169 1% |
| Squamous Cell Lung Carcinoma | 1/57 2% | 3/810 0% |
| Mesothelioma | 1/62 2% | 0/165 0% |
| Non-Small Cell Lung Carcinoma | 5/304 2% | 1/1390 0% |
| Plasma Cell Myeloma | 1/44 2% | 0/305 0% |
| Melanoma | 0/210 0% | 6/1899 0% |
| Small Cell Lung Carcinoma | 0/9 0% | 2/752 0% |
| Other Sarcomas | 0/69 0% | 2/699 0% |
| Thyroid Gland Carcinoma | 1/45 2% | 3/1592 0% |
| Cervical Carcinoma | 0/35 0% | 1/422 0% |
| Non-Cancerous | 1/104 1% | 1/830 0% |
| Gastric Carcinoma | 1/74 1% | 3/1809 0% |
| Colorectal Carcinoma | 0/143 0% | 6/3239 0% |
| Glioma | 1/52 2% | 3/2127 0% |
| Endometrial Carcinoma | 0/42 0% | 1/612 0% |
| Neuroblastoma | 2/87 2% | 0/1331 0% |
| Esophageal Squamous Cell Carcinoma | 2/51 4% | 1/2550 0% |
| Other Blood Cancers | 3/61 5% | 0/2725 0% |
| B-Lymphoblastic Leukemia | 2/55 4% | 1/2640 0% |
| Bladder Carcinoma | 1/58 2% | 0/956 0% |
| Ovarian Carcinoma | 1/109 1% | 0/998 0% |
| Breast Carcinoma | 2/144 1% | 1/3264 0% |
| Pancreatic Carcinoma | 1/89 1% | 0/1611 0% |
| Other Solid Cancers | 0/94 0% | 1/1515 0% |
Mutation Distribution
Where RETN is mutated · all tissues, split by cell line vs tissue
How many mutations in RETN were found in each tissue, across the whole database.
Each bar is a tissue (cell-line and tissue names are merged to the standard tissue), split into cell line and tissue (patient tumour) contributions.
This shows the cancer-context where this gene is recurrently altered.
GTEx Expression
Median TPM across 51 healthy tissues
Median gene expression (TPM) in normal, non-cancer human tissues from the GTEx project.
Useful for judging tumour specificity – a strong neoantigen target ideally comes from a gene with low expression in healthy tissues.
Scroll or drag the mini-axis below the chart to browse all tissues.
Mutations
All 142 mutations in RETN
Every mutation record for this gene, across all samples and sources.
The Sample column links to the cell line (cell-line samples) or the tissue type (tissue samples).
Use the Type / Source filters, the search box, and column sorting to explore; each CAN-IMMUNE ID opens the full mutation & peptide view.
| ID | Sample | Transcript | AA Change | CDS | Type | Source | Mutant Peptide | Wild-type Peptide |
|---|