Stats by Source
Total, split by cell line (COSMIC CL / DepMap / PubMed) vs tissue (COSMIC primary tissue)
Total = all mutations for this gene across every source.
Cell line = COSMIC Cell Lines Project + DepMap + PubMed.
Tissue = COSMIC primary-tissue (patient tumour) samples.
Total can exceed cell line + tissue: COSMIC tissue-derived models sit only in global, and a peptide can be shared across both.
| Total | Cell line | Tissue | |
|---|---|---|---|
| Mutations | 229 | 31 | 193 |
| Samples | 226 | 31 | 190 |
| Peptides | 170 | 18 | 154 |
Function
RGS18 · Regulator of G protein signaling 18
This gene encodes a member of the regulator of G-protein signaling family. This protein is contains a conserved, 120 amino acid motif called the RGS domain. The protein attenuates the signaling activity of G-proteins by binding to activated, GTP-bound G alpha subunits and acting as a GTPase activating protein (GAP), increasing the rate of conversion of the GTP to GDP. This hydrolysis allows the G alpha subunits to bind G beta/gamma subunit heterodimers, forming inactive G-protein heterotrimers, thereby terminating the signal. Alternate transcriptional splice variants of this gene have been observed but have not been thoroughly characterized. [provided by RefSeq, Jul 2008].
Isoforms & Proteins
1 transcript · UniProt mapping is sequence-verified (AA-safe)
Each Ensembl transcript (ENST) this gene is mutated on, with its matched UniProt accession.
The mapping is sequence-verified: the UniProt sequence is identical to the transcript translation, so amino-acid positions line up exactly. A * marks an unreviewed (TrEMBL) entry.
Counts are mutations and unique mutant peptides on each transcript.
| Transcript | UniProt | Mutations | Peptides |
|---|---|---|---|
| ENST00000367460 | Q9NS28 | 229 | 170 |
Gene Properties
Recurrent Mutations
All 170 amino-acid changes on canonical ENST00000367460 · needle height = samples · drag the mini-map to zoom
A lollipop / needle plot – the standard way to show recurrent mutations along a protein (as used by cBioPortal and MutationMapper).
X-axis = amino-acid position in the protein.
Needle height & head size = how often that exact amino-acid change was observed (its recurrence). Tall/large heads are mutational hotspots.
The most recurrent changes are labelled; hover any needle for the change, position and counts.
Mutation frequency across cancer types
% of samples with a missense/complex mutation in RGS18 · cell line vs tissue
For each cancer type, the fraction of samples that carry at least one missense/complex mutation anywhere in RGS18 – counted as distinct samples (a sample counts once no matter how many mutations it has).
Split into cell line and tissue; each cell shows mutated / total and the percentage. Cohorts with <20 samples are omitted. Ordered by combined frequency.
| Cancer type | Cell lines | Tissue samples |
|---|---|---|
| Oral Cavity Carcinoma | 2/54 4% | 0/0 0% |
| Melanoma | 2/210 1% | 42/1899 2% |
| Non-Small Cell Lung Carcinoma | 8/304 3% | 23/1390 2% |
| Hodgkins Lymphoma | 0/16 0% | 2/122 2% |
| Osteosarcoma | 2/45 4% | 1/166 1% |
| Squamous Cell Lung Carcinoma | 0/57 0% | 11/810 1% |
| Gastric Carcinoma | 0/74 0% | 18/1809 1% |
| Other Solid Cancers | 0/94 0% | 12/1515 1% |
| Neuroendocrine Tumour | 3/154 2% | 2/577 0% |
| Other Sarcomas | 3/69 4% | 2/699 0% |
| Small Cell Lung Carcinoma | 0/9 0% | 4/752 1% |
| Colorectal Carcinoma | 3/143 2% | 15/3239 0% |
| Germ Cell Tumour | 0/25 0% | 1/169 1% |
| Bladder Carcinoma | 0/58 0% | 5/956 1% |
| Rhabdomyosarcoma | 1/33 3% | 0/171 0% |
| Hepatocellular Carcinoma | 0/46 0% | 11/2210 0% |
| Head and Neck Carcinoma | 1/85 1% | 7/1574 0% |
| Endometrial Carcinoma | 0/42 0% | 3/612 0% |
| Esophageal Squamous Cell Carcinoma | 0/51 0% | 12/2550 0% |
| Cervical Carcinoma | 0/35 0% | 2/422 0% |
| Medulloblastoma | 0/0 0% | 2/450 0% |
| Mesothelioma | 1/62 2% | 0/165 0% |
| Biliary Tract Carcinoma | 0/54 0% | 4/950 0% |
| Ovarian Carcinoma | 0/109 0% | 3/998 0% |
| Prostate Carcinoma | 2/13 15% | 3/2105 0% |
| Kidney Carcinoma | 2/85 2% | 2/1862 0% |
| Neuroblastoma | 0/87 0% | 2/1331 0% |
| Glioma | 1/52 2% | 2/2127 0% |
| Non-Cancerous | 0/104 0% | 1/830 0% |
| Thyroid Gland Carcinoma | 0/45 0% | 1/1592 0% |
Mutation Distribution
Where RGS18 is mutated · all tissues, split by cell line vs tissue
How many mutations in RGS18 were found in each tissue, across the whole database.
Each bar is a tissue (cell-line and tissue names are merged to the standard tissue), split into cell line and tissue (patient tumour) contributions.
This shows the cancer-context where this gene is recurrently altered.
GTEx Expression
Median TPM across 52 healthy tissues
Median gene expression (TPM) in normal, non-cancer human tissues from the GTEx project.
Useful for judging tumour specificity – a strong neoantigen target ideally comes from a gene with low expression in healthy tissues.
Scroll or drag the mini-axis below the chart to browse all tissues.
Mutations
All 229 mutations in RGS18
Every mutation record for this gene, across all samples and sources.
The Sample column links to the cell line (cell-line samples) or the tissue type (tissue samples).
Use the Type / Source filters, the search box, and column sorting to explore; each CAN-IMMUNE ID opens the full mutation & peptide view.
| ID | Sample | Transcript | AA Change | CDS | Type | Source | Mutant Peptide | Wild-type Peptide |
|---|