Stats by Source
Total, split by cell line (COSMIC CL / DepMap / PubMed) vs tissue (COSMIC primary tissue)
Total = all mutations for this gene across every source.
Cell line = COSMIC Cell Lines Project + DepMap + PubMed.
Tissue = COSMIC primary-tissue (patient tumour) samples.
Total can exceed cell line + tissue: COSMIC tissue-derived models sit only in global, and a peptide can be shared across both.
| Total | Cell line | Tissue | |
|---|---|---|---|
| Mutations | 3,281 | 415 | 2,829 |
| Samples | 1,407 | 256 | 1,134 |
| Peptides | 1,225 | 184 | 1,077 |
Function
ROS1 · ROS proto-oncogene 1, receptor tyrosine kinase
This proto-oncogene, highly-expressed in a variety of tumor cell lines, belongs to the sevenless subfamily of tyrosine kinase insulin receptor genes. The protein encoded by this gene is a type I integral membrane protein with tyrosine kinase activity. The protein may function as a growth or differentiation factor receptor. [provided by RefSeq, Jul 2008].
Isoforms & Proteins
2 transcripts · UniProt mapping is sequence-verified (AA-safe)
Each Ensembl transcript (ENST) this gene is mutated on, with its matched UniProt accession.
The mapping is sequence-verified: the UniProt sequence is identical to the transcript translation, so amino-acid positions line up exactly. A * marks an unreviewed (TrEMBL) entry.
Counts are mutations and unique mutant peptides on each transcript.
Gene Properties
Recurrent Mutations
All 1139 amino-acid changes on canonical ENST00000368508 · needle height = samples · drag the mini-map to zoom
A lollipop / needle plot – the standard way to show recurrent mutations along a protein (as used by cBioPortal and MutationMapper).
X-axis = amino-acid position in the protein.
Needle height & head size = how often that exact amino-acid change was observed (its recurrence). Tall/large heads are mutational hotspots.
The most recurrent changes are labelled; hover any needle for the change, position and counts.
Mutation frequency across cancer types
% of samples with a missense/complex mutation in ROS1 · cell line vs tissue
For each cancer type, the fraction of samples that carry at least one missense/complex mutation anywhere in ROS1 – counted as distinct samples (a sample counts once no matter how many mutations it has).
Split into cell line and tissue; each cell shows mutated / total and the percentage. Cohorts with <20 samples are omitted. Ordered by combined frequency.
| Cancer type | Cell lines | Tissue samples |
|---|---|---|
| T-Lymphoblastic Leukemia | 9/40 22% | 0/0 0% |
| Melanoma | 26/210 12% | 249/1899 13% |
| Oral Cavity Carcinoma | 7/54 13% | 0/0 0% |
| Endometrial Carcinoma | 17/42 40% | 54/612 9% |
| Chordoma | 1/7 14% | 1/13 8% |
| Chronic Myelogenous Leukemia | 2/25 8% | 0/0 0% |
| T-Cell Non-Hodgkins Lymphoma | 2/26 8% | 0/0 0% |
| Glioblastoma | 7/98 7% | 0/0 0% |
| Other Solid Cancers | 6/94 6% | 104/1515 7% |
| Squamous Cell Lung Carcinoma | 3/57 5% | 53/810 7% |
| Small Cell Lung Carcinoma | 2/9 22% | 38/752 5% |
| Gastric Carcinoma | 7/74 9% | 71/1809 4% |
| Neuroendocrine Tumour | 24/154 16% | 6/577 1% |
| Non-Small Cell Lung Carcinoma | 18/304 6% | 49/1390 4% |
| Acute Monocytic Leukemia | 0/1 0% | 1/25 4% |
| Colorectal Carcinoma | 21/143 15% | 108/3239 3% |
| Bladder Carcinoma | 2/58 3% | 32/956 3% |
| Head and Neck Carcinoma | 7/85 8% | 44/1574 3% |
| Gastrointestinal Stromal Tumour | 0/0 0% | 4/133 3% |
| Osteosarcoma | 2/45 4% | 4/166 2% |
| Germ Cell Tumour | 4/25 16% | 1/169 1% |
| Unknown | 0/10 0% | 1/29 3% |
| Rhabdomyosarcoma | 3/33 9% | 2/171 1% |
| Acute Myeloid Leukemia | 2/90 2% | 0/0 0% |
| Other Sarcomas | 6/69 9% | 11/699 2% |
| Cervical Carcinoma | 1/35 3% | 9/422 2% |
| Hepatocellular Carcinoma | 10/46 22% | 37/2210 2% |
| Ovarian Carcinoma | 5/109 5% | 15/998 2% |
| Plasma Cell Myeloma | 2/44 5% | 4/305 1% |
| Glioma | 2/52 4% | 35/2127 2% |
Mutation Distribution
Where ROS1 is mutated · all tissues, split by cell line vs tissue
How many mutations in ROS1 were found in each tissue, across the whole database.
Each bar is a tissue (cell-line and tissue names are merged to the standard tissue), split into cell line and tissue (patient tumour) contributions.
This shows the cancer-context where this gene is recurrently altered.
GTEx Expression
Median TPM across 32 healthy tissues
Median gene expression (TPM) in normal, non-cancer human tissues from the GTEx project.
Useful for judging tumour specificity – a strong neoantigen target ideally comes from a gene with low expression in healthy tissues.
Scroll or drag the mini-axis below the chart to browse all tissues.
Mutations
All 3,281 mutations in ROS1
Every mutation record for this gene, across all samples and sources.
The Sample column links to the cell line (cell-line samples) or the tissue type (tissue samples).
Use the Type / Source filters, the search box, and column sorting to explore; each CAN-IMMUNE ID opens the full mutation & peptide view.
| ID | Sample | Transcript | AA Change | CDS | Type | Source | Mutant Peptide | Wild-type Peptide |
|---|