Stats by Source
Total, split by cell line (COSMIC CL / DepMap / PubMed) vs tissue (COSMIC primary tissue)
Total = all mutations for this gene across every source.
Cell line = COSMIC Cell Lines Project + DepMap + PubMed.
Tissue = COSMIC primary-tissue (patient tumour) samples.
Total can exceed cell line + tissue: COSMIC tissue-derived models sit only in global, and a peptide can be shared across both.
| Total | Cell line | Tissue | |
|---|---|---|---|
| Mutations | 968 | 123 | 844 |
| Samples | 211 | 42 | 168 |
| Peptides | 220 | 36 | 187 |
Function
SCP2 · Sterol carrier protein 2
This gene encodes two proteins: sterol carrier protein X (SCPx) and sterol carrier protein 2 (SCP2), as a result of transcription initiation from 2 independently regulated promoters. The transcript initiated from the proximal promoter encodes the longer SCPx protein, and the transcript initiated from the distal promoter encodes the shorter SCP2 protein, with the 2 proteins sharing a common C-terminus. Evidence suggests that the SCPx protein is a peroxisome-associated thiolase that is involved in the oxidation of branched chain fatty acids, while the SCP2 protein is thought to be an intracellular lipid transfer protein. This gene is highly expressed in organs involved in lipid metabolism, and may play a role in Zellweger syndrome, in which cells are deficient in peroxisomes and have impaired bile acid synthesis. Alternative splicing of this gene produces multiple transcript variants, some encoding different isoforms.[provided by RefSeq, Aug 2010].
Isoforms & Proteins
10 transcripts · UniProt mapping is sequence-verified (AA-safe)
Each Ensembl transcript (ENST) this gene is mutated on, with its matched UniProt accession.
The mapping is sequence-verified: the UniProt sequence is identical to the transcript translation, so amino-acid positions line up exactly. A * marks an unreviewed (TrEMBL) entry.
Counts are mutations and unique mutant peptides on each transcript.
| Transcript | UniProt | Mutations | Peptides |
|---|---|---|---|
| ENST00000371514 | P22307 | 210 | 167 |
| ENST00000407246 | P22307-8 | 180 | 150 |
| ENST00000371509 | P22307-7 | 163 | 136 |
| ENST00000528311 | P22307-4 | 158 | 132 |
| ENST00000371513 | P22307-3 | 98 | 83 |
| ENST00000435345 | P22307-2 | 50 | 41 |
| ENST00000430330 | P22307-6 | 46 | 39 |
| ENST00000408941 | P22307-5 | 28 | 23 |
| ENST00000488965 | P22307-5 | 28 | 23 |
| ENST00000357552 | Q9BX26 | 7 | 6 |
Gene Properties
Recurrent Mutations
All 167 amino-acid changes on canonical ENST00000371514 · needle height = samples · drag the mini-map to zoom
A lollipop / needle plot – the standard way to show recurrent mutations along a protein (as used by cBioPortal and MutationMapper).
X-axis = amino-acid position in the protein.
Needle height & head size = how often that exact amino-acid change was observed (its recurrence). Tall/large heads are mutational hotspots.
The most recurrent changes are labelled; hover any needle for the change, position and counts.
Mutation frequency across cancer types
% of samples with a missense/complex mutation in SCP2 · cell line vs tissue
For each cancer type, the fraction of samples that carry at least one missense/complex mutation anywhere in SCP2 – counted as distinct samples (a sample counts once no matter how many mutations it has).
Split into cell line and tissue; each cell shows mutated / total and the percentage. Cohorts with <20 samples are omitted. Ordered by combined frequency.
| Cancer type | Cell lines | Tissue samples |
|---|---|---|
| T-Lymphoblastic Leukemia | 2/40 5% | 0/0 0% |
| Chronic Myelogenous Leukemia | 1/25 4% | 0/0 0% |
| Glioblastoma | 3/98 3% | 0/0 0% |
| Endometrial Carcinoma | 0/42 0% | 15/612 2% |
| Melanoma | 3/210 1% | 23/1899 1% |
| Bladder Carcinoma | 0/58 0% | 8/956 1% |
| Other Solid Cancers | 2/94 2% | 10/1515 1% |
| Non-Small Cell Lung Carcinoma | 3/304 1% | 9/1390 1% |
| Neuroendocrine Tumour | 2/154 1% | 3/577 1% |
| Colorectal Carcinoma | 5/143 4% | 16/3239 0% |
| Squamous Cell Lung Carcinoma | 0/57 0% | 5/810 1% |
| Head and Neck Carcinoma | 2/85 2% | 7/1574 0% |
| Other Sarcomas | 0/69 0% | 4/699 1% |
| Rhabdomyosarcoma | 0/33 0% | 1/171 1% |
| Osteosarcoma | 1/45 2% | 0/166 0% |
| Breast Carcinoma | 4/144 3% | 10/3264 0% |
| Small Cell Lung Carcinoma | 1/9 11% | 2/752 0% |
| Esophageal Carcinoma | 0/23 0% | 3/769 0% |
| Gastric Carcinoma | 0/74 0% | 7/1809 0% |
| Thyroid Gland Carcinoma | 1/45 2% | 5/1592 0% |
| Hepatocellular Carcinoma | 0/46 0% | 8/2210 0% |
| Kidney Carcinoma | 1/85 1% | 5/1862 0% |
| Plasma Cell Myeloma | 0/44 0% | 1/305 0% |
| Neuroblastoma | 3/87 3% | 1/1331 0% |
| Ovarian Carcinoma | 2/109 2% | 1/998 0% |
| Pancreatic Carcinoma | 0/89 0% | 4/1611 0% |
| B-Cell Non-Hodgkins Lymphoma | 1/88 1% | 5/2534 0% |
| Other Blood Cancers | 3/61 5% | 3/2725 0% |
| Cervical Carcinoma | 0/35 0% | 1/422 0% |
| Non-Cancerous | 0/104 0% | 2/830 0% |
Mutation Distribution
Where SCP2 is mutated · all tissues, split by cell line vs tissue
How many mutations in SCP2 were found in each tissue, across the whole database.
Each bar is a tissue (cell-line and tissue names are merged to the standard tissue), split into cell line and tissue (patient tumour) contributions.
This shows the cancer-context where this gene is recurrently altered.
GTEx Expression
Median TPM across 54 healthy tissues
Median gene expression (TPM) in normal, non-cancer human tissues from the GTEx project.
Useful for judging tumour specificity – a strong neoantigen target ideally comes from a gene with low expression in healthy tissues.
Scroll or drag the mini-axis below the chart to browse all tissues.
Mutations
All 968 mutations in SCP2
Every mutation record for this gene, across all samples and sources.
The Sample column links to the cell line (cell-line samples) or the tissue type (tissue samples).
Use the Type / Source filters, the search box, and column sorting to explore; each CAN-IMMUNE ID opens the full mutation & peptide view.
| ID | Sample | Transcript | AA Change | CDS | Type | Source | Mutant Peptide | Wild-type Peptide |
|---|