Stats by Source
Total, split by cell line (COSMIC CL / DepMap / PubMed) vs tissue (COSMIC primary tissue)
Total = all mutations for this gene across every source.
Cell line = COSMIC Cell Lines Project + DepMap + PubMed.
Tissue = COSMIC primary-tissue (patient tumour) samples.
Total can exceed cell line + tissue: COSMIC tissue-derived models sit only in global, and a peptide can be shared across both.
| Total | Cell line | Tissue | |
|---|---|---|---|
| Mutations | 1,465 | 324 | 1,105 |
| Samples | 1,273 | 271 | 968 |
| Peptides | 968 | 203 | 806 |
Function
SDK2 · Sidekick cell adhesion molecule 2
The protein encoded by this gene is a member of the immunoglobulin superfamily. The protein contains two immunoglobulin domains and thirteen fibronectin type III domains. Fibronectin type III domains are present in both extracellular and intracellular proteins and tandem repeats are known to contain binding sites for DNA, heparin and the cell surface. This protein, and a homologous mouse sequence, are very similar to the Drosophila sidekick gene product but the specific function of this superfamily member is not yet known. Evidence for alternative splicing at this gene locus has been observed but the full-length nature of additional variants has not yet been determined. [provided by RefSeq, Jul 2008].
Isoforms & Proteins
1 transcript · UniProt mapping is sequence-verified (AA-safe)
Each Ensembl transcript (ENST) this gene is mutated on, with its matched UniProt accession.
The mapping is sequence-verified: the UniProt sequence is identical to the transcript translation, so amino-acid positions line up exactly. A * marks an unreviewed (TrEMBL) entry.
Counts are mutations and unique mutant peptides on each transcript.
| Transcript | UniProt | Mutations | Peptides |
|---|---|---|---|
| ENST00000392650 | Q58EX2 | 1,465 | 968 |
Gene Properties
Recurrent Mutations
All 968 amino-acid changes on canonical ENST00000392650 · needle height = samples · drag the mini-map to zoom
A lollipop / needle plot – the standard way to show recurrent mutations along a protein (as used by cBioPortal and MutationMapper).
X-axis = amino-acid position in the protein.
Needle height & head size = how often that exact amino-acid change was observed (its recurrence). Tall/large heads are mutational hotspots.
The most recurrent changes are labelled; hover any needle for the change, position and counts.
Mutation frequency across cancer types
% of samples with a missense/complex mutation in SDK2 · cell line vs tissue
For each cancer type, the fraction of samples that carry at least one missense/complex mutation anywhere in SDK2 – counted as distinct samples (a sample counts once no matter how many mutations it has).
Split into cell line and tissue; each cell shows mutated / total and the percentage. Cohorts with <20 samples are omitted. Ordered by combined frequency.
| Cancer type | Cell lines | Tissue samples |
|---|---|---|
| T-Lymphoblastic Leukemia | 10/40 25% | 0/0 0% |
| T-Cell Non-Hodgkins Lymphoma | 4/26 15% | 0/0 0% |
| Endometrial Carcinoma | 14/42 33% | 41/612 7% |
| Melanoma | 15/210 7% | 156/1899 8% |
| Chronic Myelogenous Leukemia | 2/25 8% | 0/0 0% |
| Hodgkins Lymphoma | 2/16 12% | 8/122 7% |
| Non-Small Cell Lung Carcinoma | 41/304 13% | 64/1390 5% |
| Glioblastoma | 6/98 6% | 0/0 0% |
| Gastric Carcinoma | 9/74 12% | 83/1809 5% |
| Colorectal Carcinoma | 33/143 23% | 132/3239 4% |
| Gastrointestinal Stromal Tumour | 0/0 0% | 6/133 5% |
| Oral Cavity Carcinoma | 2/54 4% | 0/0 0% |
| Other Solid Cancers | 13/94 14% | 44/1515 3% |
| Meningioma | 1/3 33% | 8/252 3% |
| Squamous Cell Lung Carcinoma | 10/57 18% | 20/810 2% |
| Cervical Carcinoma | 2/35 6% | 11/422 3% |
| Esophageal Squamous Cell Carcinoma | 6/51 12% | 64/2550 3% |
| Mesothelioma | 5/62 8% | 1/165 1% |
| Hepatocellular Carcinoma | 2/46 4% | 51/2210 2% |
| Small Cell Lung Carcinoma | 0/9 0% | 17/752 2% |
| Acute Myeloid Leukemia | 2/90 2% | 0/0 0% |
| Burkitts Lymphoma | 5/32 16% | 0/196 0% |
| Biliary Tract Carcinoma | 3/54 6% | 19/950 2% |
| Germ Cell Tumour | 1/25 4% | 3/169 2% |
| Other Sarcomas | 4/69 6% | 10/699 1% |
| Esophageal Carcinoma | 1/23 4% | 13/769 2% |
| Bladder Carcinoma | 6/58 10% | 11/956 1% |
| Thyroid Gland Carcinoma | 4/45 9% | 23/1592 1% |
| Ovarian Carcinoma | 5/109 5% | 13/998 1% |
| Ewings Sarcoma | 2/63 3% | 3/262 1% |
Mutation Distribution
Where SDK2 is mutated · all tissues, split by cell line vs tissue
How many mutations in SDK2 were found in each tissue, across the whole database.
Each bar is a tissue (cell-line and tissue names are merged to the standard tissue), split into cell line and tissue (patient tumour) contributions.
This shows the cancer-context where this gene is recurrently altered.
GTEx Expression
Median TPM across 54 healthy tissues
Median gene expression (TPM) in normal, non-cancer human tissues from the GTEx project.
Useful for judging tumour specificity – a strong neoantigen target ideally comes from a gene with low expression in healthy tissues.
Scroll or drag the mini-axis below the chart to browse all tissues.
Mutations
All 1,465 mutations in SDK2
Every mutation record for this gene, across all samples and sources.
The Sample column links to the cell line (cell-line samples) or the tissue type (tissue samples).
Use the Type / Source filters, the search box, and column sorting to explore; each CAN-IMMUNE ID opens the full mutation & peptide view.
| ID | Sample | Transcript | AA Change | CDS | Type | Source | Mutant Peptide | Wild-type Peptide |
|---|