Stats by Source
Total, split by cell line (COSMIC CL / DepMap / PubMed) vs tissue (COSMIC primary tissue)
Total = all mutations for this gene across every source.
Cell line = COSMIC Cell Lines Project + DepMap + PubMed.
Tissue = COSMIC primary-tissue (patient tumour) samples.
Total can exceed cell line + tissue: COSMIC tissue-derived models sit only in global, and a peptide can be shared across both.
| Total | Cell line | Tissue | |
|---|---|---|---|
| Mutations | 1,312 | 184 | 1,110 |
| Samples | 687 | 114 | 562 |
| Peptides | 544 | 88 | 470 |
Function
SEMA3E · Semaphorin 3E
Semaphorins are a large family of conserved secreted and membrane associated proteins which possess a semaphorin (Sema) domain and a PSI domain (found in plexins, semaphorins and integrins) in the N-terminal extracellular portion. Based on sequence and structural similarities, semaphorins are put into eight classes: invertebrates contain classes 1 and 2, viruses have class V, and vertebrates contain classes 3-7. Semaphorins serve as axon guidance ligands via multimeric receptor complexes, some (if not all) containing plexin proteins. This gene encodes a class 4 semaphorin. This gene encodes a class 3 semaphorin. Multiple transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, May 2010].
Isoforms & Proteins
2 transcripts · UniProt mapping is sequence-verified (AA-safe)
Each Ensembl transcript (ENST) this gene is mutated on, with its matched UniProt accession.
The mapping is sequence-verified: the UniProt sequence is identical to the transcript translation, so amino-acid positions line up exactly. A * marks an unreviewed (TrEMBL) entry.
Counts are mutations and unique mutant peptides on each transcript.
| Transcript | UniProt | Mutations | Peptides |
|---|---|---|---|
| ENST00000643230 | O15041 | 791 | 539 |
| ENST00000642232 | A0A2R8YCX5* | 521 | 375 |
Gene Properties
Recurrent Mutations
All 540 amino-acid changes on canonical ENST00000643230 · needle height = samples · drag the mini-map to zoom
A lollipop / needle plot – the standard way to show recurrent mutations along a protein (as used by cBioPortal and MutationMapper).
X-axis = amino-acid position in the protein.
Needle height & head size = how often that exact amino-acid change was observed (its recurrence). Tall/large heads are mutational hotspots.
The most recurrent changes are labelled; hover any needle for the change, position and counts.
Mutation frequency across cancer types
% of samples with a missense/complex mutation in SEMA3E · cell line vs tissue
For each cancer type, the fraction of samples that carry at least one missense/complex mutation anywhere in SEMA3E – counted as distinct samples (a sample counts once no matter how many mutations it has).
Split into cell line and tissue; each cell shows mutated / total and the percentage. Cohorts with <20 samples are omitted. Ordered by combined frequency.
| Cancer type | Cell lines | Tissue samples |
|---|---|---|
| Glioblastoma | 6/98 6% | 0/0 0% |
| Melanoma | 9/210 4% | 117/1899 6% |
| Squamous Cell Lung Carcinoma | 3/57 5% | 27/810 3% |
| Non-Small Cell Lung Carcinoma | 25/304 8% | 30/1390 2% |
| Endometrial Carcinoma | 3/42 7% | 18/612 3% |
| Other Solid Cancers | 4/94 4% | 38/1515 3% |
| Unknown | 1/10 10% | 0/29 0% |
| T-Lymphoblastic Leukemia | 1/40 2% | 0/0 0% |
| Colorectal Carcinoma | 19/143 13% | 59/3239 2% |
| Gastric Carcinoma | 3/74 4% | 38/1809 2% |
| Plasma Cell Myeloma | 0/44 0% | 7/305 2% |
| Cervical Carcinoma | 2/35 6% | 7/422 2% |
| Small Cell Lung Carcinoma | 0/9 0% | 14/752 2% |
| Hepatocellular Carcinoma | 2/46 4% | 34/2210 2% |
| Bladder Carcinoma | 2/58 3% | 13/956 1% |
| Hodgkins Lymphoma | 0/16 0% | 2/122 2% |
| Esophageal Squamous Cell Carcinoma | 0/51 0% | 33/2550 1% |
| Chondrosarcoma | 0/14 0% | 1/75 1% |
| Acute Myeloid Leukemia | 1/90 1% | 0/0 0% |
| Germ Cell Tumour | 1/25 4% | 1/169 1% |
| Esophageal Carcinoma | 0/23 0% | 8/769 1% |
| Osteosarcoma | 1/45 2% | 1/166 1% |
| Head and Neck Carcinoma | 2/85 2% | 13/1574 1% |
| Adrenocortical Carcinoma | 0/3 0% | 1/112 1% |
| Glioma | 1/52 2% | 17/2127 1% |
| B-Cell Non-Hodgkins Lymphoma | 5/88 6% | 15/2534 1% |
| Pancreatic Carcinoma | 1/89 1% | 12/1611 1% |
| Gastrointestinal Stromal Tumour | 0/0 0% | 1/133 1% |
| Prostate Carcinoma | 0/13 0% | 15/2105 1% |
| Ovarian Carcinoma | 5/109 5% | 2/998 0% |
Mutation Distribution
Where SEMA3E is mutated · all tissues, split by cell line vs tissue
How many mutations in SEMA3E were found in each tissue, across the whole database.
Each bar is a tissue (cell-line and tissue names are merged to the standard tissue), split into cell line and tissue (patient tumour) contributions.
This shows the cancer-context where this gene is recurrently altered.
GTEx Expression
Median TPM across 52 healthy tissues
Median gene expression (TPM) in normal, non-cancer human tissues from the GTEx project.
Useful for judging tumour specificity – a strong neoantigen target ideally comes from a gene with low expression in healthy tissues.
Scroll or drag the mini-axis below the chart to browse all tissues.
Mutations
All 1,312 mutations in SEMA3E
Every mutation record for this gene, across all samples and sources.
The Sample column links to the cell line (cell-line samples) or the tissue type (tissue samples).
Use the Type / Source filters, the search box, and column sorting to explore; each CAN-IMMUNE ID opens the full mutation & peptide view.
| ID | Sample | Transcript | AA Change | CDS | Type | Source | Mutant Peptide | Wild-type Peptide |
|---|