Stats by Source
Total, split by cell line (COSMIC CL / DepMap / PubMed) vs tissue (COSMIC primary tissue)
Total = all mutations for this gene across every source.
Cell line = COSMIC Cell Lines Project + DepMap + PubMed.
Tissue = COSMIC primary-tissue (patient tumour) samples.
Total can exceed cell line + tissue: COSMIC tissue-derived models sit only in global, and a peptide can be shared across both.
| Total | Cell line | Tissue | |
|---|---|---|---|
| Mutations | 60 | 53 | 0 |
| Samples | 55 | 50 | 0 |
| Peptides | 56 | 49 | 0 |
Function
SEPTIN4 · Septin 4
This gene is a member of the septin family of nucleotide binding proteins, originally described in yeast as cell division cycle regulatory proteins. Septins are highly conserved in yeast, Drosophila, and mouse, and appear to regulate cytoskeletal organization. Disruption of septin function disturbs cytokinesis and results in large multinucleate or polyploid cells. This gene is highly expressed in brain and heart. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. One of the isoforms (known as ARTS) is distinct; it is localized to the mitochondria, and has a role in apoptosis and cancer. [provided by RefSeq, Nov 2010].
Isoforms & Proteins
2 transcripts · UniProt mapping is sequence-verified (AA-safe)
Each Ensembl transcript (ENST) this gene is mutated on, with its matched UniProt accession.
The mapping is sequence-verified: the UniProt sequence is identical to the transcript translation, so amino-acid positions line up exactly. A * marks an unreviewed (TrEMBL) entry.
Counts are mutations and unique mutant peptides on each transcript.
Gene Properties
Recurrent Mutations
All 49 amino-acid changes on canonical ENST00000672673 · needle height = samples · drag the mini-map to zoom
A lollipop / needle plot – the standard way to show recurrent mutations along a protein (as used by cBioPortal and MutationMapper).
X-axis = amino-acid position in the protein.
Needle height & head size = how often that exact amino-acid change was observed (its recurrence). Tall/large heads are mutational hotspots.
The most recurrent changes are labelled; hover any needle for the change, position and counts.
Mutation frequency across cancer types
% of samples with a missense/complex mutation in SEPTIN4 · cell line vs tissue
For each cancer type, the fraction of samples that carry at least one missense/complex mutation anywhere in SEPTIN4 – counted as distinct samples (a sample counts once no matter how many mutations it has).
Split into cell line and tissue; each cell shows mutated / total and the percentage. Cohorts with <20 samples are omitted. Ordered by combined frequency.
| Cancer type | Cell lines | Tissue samples |
|---|---|---|
| Chordoma | 1/7 14% | 0/13 0% |
| T-Lymphoblastic Leukemia | 1/40 2% | 0/0 0% |
| Oral Cavity Carcinoma | 1/54 2% | 0/0 0% |
| Endometrial Carcinoma | 6/42 14% | 1/612 0% |
| Glioblastoma | 1/98 1% | 0/0 0% |
| Neuroendocrine Tumour | 3/154 2% | 0/577 0% |
| Colorectal Carcinoma | 9/143 6% | 1/3239 0% |
| Neuroblastoma | 4/87 5% | 0/1331 0% |
| Non-Small Cell Lung Carcinoma | 3/304 1% | 1/1390 0% |
| Non-Cancerous | 2/104 2% | 0/830 0% |
| Gastric Carcinoma | 2/74 3% | 1/1809 0% |
| Melanoma | 3/210 1% | 0/1899 0% |
| Squamous Cell Lung Carcinoma | 1/57 2% | 0/810 0% |
| Head and Neck Carcinoma | 2/85 2% | 0/1574 0% |
| Bladder Carcinoma | 0/58 0% | 1/956 0% |
| Breast Carcinoma | 3/144 2% | 0/3264 0% |
| B-Cell Non-Hodgkins Lymphoma | 2/88 2% | 0/2534 0% |
| Pancreatic Carcinoma | 1/89 1% | 0/1611 0% |
| Other Solid Cancers | 1/94 1% | 0/1515 0% |
| Prostate Carcinoma | 1/13 8% | 0/2105 0% |
| Kidney Carcinoma | 1/85 1% | 0/1862 0% |
| Esophageal Squamous Cell Carcinoma | 1/51 2% | 0/2550 0% |
| B-Lymphoblastic Leukemia | 1/55 2% | 0/2640 0% |
Mutation Distribution
Where SEPTIN4 is mutated · all tissues, split by cell line vs tissue
How many mutations in SEPTIN4 were found in each tissue, across the whole database.
Each bar is a tissue (cell-line and tissue names are merged to the standard tissue), split into cell line and tissue (patient tumour) contributions.
This shows the cancer-context where this gene is recurrently altered.
Mutations
All 60 mutations in SEPTIN4
Every mutation record for this gene, across all samples and sources.
The Sample column links to the cell line (cell-line samples) or the tissue type (tissue samples).
Use the Type / Source filters, the search box, and column sorting to explore; each CAN-IMMUNE ID opens the full mutation & peptide view.
| ID | Sample | Transcript | AA Change | CDS | Type | Source | Mutant Peptide | Wild-type Peptide |
|---|