Stats by Source
Total, split by cell line (COSMIC CL / DepMap / PubMed) vs tissue (COSMIC primary tissue)
Total = all mutations for this gene across every source.
Cell line = COSMIC Cell Lines Project + DepMap + PubMed.
Tissue = COSMIC primary-tissue (patient tumour) samples.
Total can exceed cell line + tissue: COSMIC tissue-derived models sit only in global, and a peptide can be shared across both.
| Total | Cell line | Tissue | |
|---|---|---|---|
| Mutations | 738 | 127 | 606 |
| Samples | 378 | 83 | 292 |
| Peptides | 265 | 51 | 222 |
Function
SERPINA7 · Serpin family A member 7
There are three proteins including thyroxine-binding globulin (TBG), transthyretin and albumin responsible for carrying the thyroid hormones thyroxine (T4) and 3,5,3'-triiodothyronine (T3) in the bloodstream. This gene encodes the major thyroid hormone transport protein, TBG, in serum. It belongs to the serpin family in genomics, but the protein has no inhibitory function like many other members of the serpin family. Mutations in this gene result in TGB deficiency, which has been classified as partial deficiency, complete deficiency, and excess, based on the level of serum TBG. Alternatively spliced transcript variants encoding different isoforms have been found, but the full-length nature of these variants has not been determined.[provided by RefSeq, Jun 2012].
Isoforms & Proteins
2 transcripts · UniProt mapping is sequence-verified (AA-safe)
Each Ensembl transcript (ENST) this gene is mutated on, with its matched UniProt accession.
The mapping is sequence-verified: the UniProt sequence is identical to the transcript translation, so amino-acid positions line up exactly. A * marks an unreviewed (TrEMBL) entry.
Counts are mutations and unique mutant peptides on each transcript.
Gene Properties
Recurrent Mutations
All 265 amino-acid changes on canonical ENST00000372563 · needle height = samples · drag the mini-map to zoom
A lollipop / needle plot – the standard way to show recurrent mutations along a protein (as used by cBioPortal and MutationMapper).
X-axis = amino-acid position in the protein.
Needle height & head size = how often that exact amino-acid change was observed (its recurrence). Tall/large heads are mutational hotspots.
The most recurrent changes are labelled; hover any needle for the change, position and counts.
Mutation frequency across cancer types
% of samples with a missense/complex mutation in SERPINA7 · cell line vs tissue
For each cancer type, the fraction of samples that carry at least one missense/complex mutation anywhere in SERPINA7 – counted as distinct samples (a sample counts once no matter how many mutations it has).
Split into cell line and tissue; each cell shows mutated / total and the percentage. Cohorts with <20 samples are omitted. Ordered by combined frequency.
| Cancer type | Cell lines | Tissue samples |
|---|---|---|
| T-Lymphoblastic Leukemia | 6/40 15% | 0/0 0% |
| Melanoma | 11/210 5% | 84/1899 4% |
| Glioblastoma | 4/98 4% | 0/0 0% |
| Acute Monocytic Leukemia | 0/1 0% | 1/25 4% |
| Endometrial Carcinoma | 1/42 2% | 16/612 3% |
| Hodgkins Lymphoma | 0/16 0% | 3/122 2% |
| Non-Small Cell Lung Carcinoma | 11/304 4% | 25/1390 2% |
| Cervical Carcinoma | 1/35 3% | 6/422 1% |
| Other Solid Cancers | 1/94 1% | 21/1515 1% |
| Mesothelioma | 3/62 5% | 0/165 0% |
| Gastric Carcinoma | 5/74 7% | 19/1809 1% |
| Ovarian Carcinoma | 6/109 6% | 8/998 1% |
| Neuroendocrine Tumour | 8/154 5% | 1/577 0% |
| Acute Myeloid Leukemia | 1/90 1% | 0/0 0% |
| Squamous Cell Lung Carcinoma | 1/57 2% | 8/810 1% |
| Small Cell Lung Carcinoma | 0/9 0% | 7/752 1% |
| Plasma Cell Myeloma | 2/44 5% | 1/305 0% |
| Colorectal Carcinoma | 7/143 5% | 22/3239 1% |
| Esophageal Carcinoma | 0/23 0% | 5/769 1% |
| Head and Neck Carcinoma | 0/85 0% | 9/1574 1% |
| Biliary Tract Carcinoma | 1/54 2% | 4/950 0% |
| Rhabdomyosarcoma | 0/33 0% | 1/171 1% |
| Osteosarcoma | 1/45 2% | 0/166 0% |
| Burkitts Lymphoma | 1/32 3% | 0/196 0% |
| B-Cell Non-Hodgkins Lymphoma | 1/88 1% | 10/2534 0% |
| Esophageal Squamous Cell Carcinoma | 2/51 4% | 8/2550 0% |
| Pancreatic Carcinoma | 2/89 2% | 4/1611 0% |
| Glioma | 0/52 0% | 7/2127 0% |
| Non-Cancerous | 0/104 0% | 3/830 0% |
| Breast Carcinoma | 3/144 2% | 8/3264 0% |
Mutation Distribution
Where SERPINA7 is mutated · all tissues, split by cell line vs tissue
How many mutations in SERPINA7 were found in each tissue, across the whole database.
Each bar is a tissue (cell-line and tissue names are merged to the standard tissue), split into cell line and tissue (patient tumour) contributions.
This shows the cancer-context where this gene is recurrently altered.
GTEx Expression
Median TPM across 7 healthy tissues
Median gene expression (TPM) in normal, non-cancer human tissues from the GTEx project.
Useful for judging tumour specificity – a strong neoantigen target ideally comes from a gene with low expression in healthy tissues.
Scroll or drag the mini-axis below the chart to browse all tissues.
Mutations
All 738 mutations in SERPINA7
Every mutation record for this gene, across all samples and sources.
The Sample column links to the cell line (cell-line samples) or the tissue type (tissue samples).
Use the Type / Source filters, the search box, and column sorting to explore; each CAN-IMMUNE ID opens the full mutation & peptide view.
| ID | Sample | Transcript | AA Change | CDS | Type | Source | Mutant Peptide | Wild-type Peptide |
|---|