Stats by Source
Total, split by cell line (COSMIC CL / DepMap / PubMed) vs tissue (COSMIC primary tissue)
Total = all mutations for this gene across every source.
Cell line = COSMIC Cell Lines Project + DepMap + PubMed.
Tissue = COSMIC primary-tissue (patient tumour) samples.
Total can exceed cell line + tissue: COSMIC tissue-derived models sit only in global, and a peptide can be shared across both.
| Total | Cell line | Tissue | |
|---|---|---|---|
| Mutations | 3,955 | 398 | 3,517 |
| Samples | 788 | 131 | 648 |
| Peptides | 621 | 92 | 555 |
Function
SLC4A10 · Solute carrier family 4 member 10
This gene belongs to a small family of sodium-coupled bicarbonate transporters (NCBTs) that regulate the intracellular pH of neurons, the secretion of bicarbonate ions across the choroid plexus, and the pH of the brain extracellular fluid. The protein encoded by this gene was initially identified as a sodium-driven chloride bicarbonate exchanger (NCBE) though there is now evidence that its sodium/bicarbonate cotransport activity is independent of any chloride ion countertransport under physiological conditions. This gene is now classified as a member A10 of the SLC4 family of transmembrane solute carriers. Alternative splicing results in multiple transcript variants encoding distinct isoforms.[provided by RefSeq, May 2010].
Isoforms & Proteins
5 transcripts · UniProt mapping is sequence-verified (AA-safe)
Each Ensembl transcript (ENST) this gene is mutated on, with its matched UniProt accession.
The mapping is sequence-verified: the UniProt sequence is identical to the transcript translation, so amino-acid positions line up exactly. A * marks an unreviewed (TrEMBL) entry.
Counts are mutations and unique mutant peptides on each transcript.
Gene Properties
Recurrent Mutations
All 585 amino-acid changes on canonical ENST00000446997 · needle height = samples · drag the mini-map to zoom
A lollipop / needle plot – the standard way to show recurrent mutations along a protein (as used by cBioPortal and MutationMapper).
X-axis = amino-acid position in the protein.
Needle height & head size = how often that exact amino-acid change was observed (its recurrence). Tall/large heads are mutational hotspots.
The most recurrent changes are labelled; hover any needle for the change, position and counts.
Mutation frequency across cancer types
% of samples with a missense/complex mutation in SLC4A10 · cell line vs tissue
For each cancer type, the fraction of samples that carry at least one missense/complex mutation anywhere in SLC4A10 – counted as distinct samples (a sample counts once no matter how many mutations it has).
Split into cell line and tissue; each cell shows mutated / total and the percentage. Cohorts with <20 samples are omitted. Ordered by combined frequency.
| Cancer type | Cell lines | Tissue samples |
|---|---|---|
| T-Lymphoblastic Leukemia | 4/40 10% | 0/0 0% |
| Melanoma | 16/210 8% | 109/1899 6% |
| Non-Small Cell Lung Carcinoma | 24/304 8% | 53/1390 4% |
| Endometrial Carcinoma | 3/42 7% | 25/612 4% |
| Squamous Cell Lung Carcinoma | 6/57 11% | 29/810 4% |
| Oral Cavity Carcinoma | 2/54 4% | 0/0 0% |
| Other Solid Cancers | 4/94 4% | 55/1515 4% |
| Gastrointestinal Stromal Tumour | 0/0 0% | 4/133 3% |
| Colorectal Carcinoma | 16/143 11% | 73/3239 2% |
| Gastric Carcinoma | 3/74 4% | 45/1809 2% |
| Small Cell Lung Carcinoma | 0/9 0% | 17/752 2% |
| Hodgkins Lymphoma | 2/16 12% | 1/122 1% |
| Cervical Carcinoma | 0/35 0% | 8/422 2% |
| Adrenocortical Carcinoma | 0/3 0% | 2/112 2% |
| Hepatocellular Carcinoma | 1/46 2% | 35/2210 2% |
| Neuroendocrine Tumour | 7/154 5% | 4/577 1% |
| Esophageal Squamous Cell Carcinoma | 5/51 10% | 33/2550 1% |
| Osteosarcoma | 3/45 7% | 0/166 0% |
| Pheochromocytoma and Paraganglioma | 0/0 0% | 1/71 1% |
| Esophageal Carcinoma | 0/23 0% | 11/769 1% |
| Ovarian Carcinoma | 5/109 5% | 8/998 1% |
| Other Sarcomas | 5/69 7% | 4/699 1% |
| Head and Neck Carcinoma | 1/85 1% | 18/1574 1% |
| Pancreatic Carcinoma | 5/89 6% | 14/1611 1% |
| Germ Cell Tumour | 1/25 4% | 1/169 1% |
| Glioma | 2/52 4% | 18/2127 1% |
| Biliary Tract Carcinoma | 0/54 0% | 9/950 1% |
| Bladder Carcinoma | 0/58 0% | 9/956 1% |
| Mesothelioma | 1/62 2% | 1/165 1% |
| Plasma Cell Myeloma | 2/44 5% | 1/305 0% |
Mutation Distribution
Where SLC4A10 is mutated · all tissues, split by cell line vs tissue
How many mutations in SLC4A10 were found in each tissue, across the whole database.
Each bar is a tissue (cell-line and tissue names are merged to the standard tissue), split into cell line and tissue (patient tumour) contributions.
This shows the cancer-context where this gene is recurrently altered.
GTEx Expression
Median TPM across 53 healthy tissues
Median gene expression (TPM) in normal, non-cancer human tissues from the GTEx project.
Useful for judging tumour specificity – a strong neoantigen target ideally comes from a gene with low expression in healthy tissues.
Scroll or drag the mini-axis below the chart to browse all tissues.
Mutations
All 3,955 mutations in SLC4A10
Every mutation record for this gene, across all samples and sources.
The Sample column links to the cell line (cell-line samples) or the tissue type (tissue samples).
Use the Type / Source filters, the search box, and column sorting to explore; each CAN-IMMUNE ID opens the full mutation & peptide view.
| ID | Sample | Transcript | AA Change | CDS | Type | Source | Mutant Peptide | Wild-type Peptide |
|---|