Stats by Source
Total, split by cell line (COSMIC CL / DepMap / PubMed) vs tissue (COSMIC primary tissue)
Total = all mutations for this gene across every source.
Cell line = COSMIC Cell Lines Project + DepMap + PubMed.
Tissue = COSMIC primary-tissue (patient tumour) samples.
Total can exceed cell line + tissue: COSMIC tissue-derived models sit only in global, and a peptide can be shared across both.
| Total | Cell line | Tissue | |
|---|---|---|---|
| Mutations | 3,729 | 509 | 3,177 |
| Samples | 823 | 169 | 648 |
| Peptides | 666 | 127 | 575 |
Function
SLC8A3 · Solute carrier family 8 member A3
This gene encodes a member of the sodium/calcium exchanger integral membrane protein family. Na+/Ca2+ exchange proteins are involved in maintaining Ca2+ homeostasis in a wide variety of cell types. The protein is regulated by intracellular calcium ions and is found in both the plasma membrane and intracellular organellar membranes, where exchange of Na+ for Ca2+ occurs in an electrogenic manner. Alternative splicing has been observed for this gene and multiple variants have been described. [provided by RefSeq, Aug 2013].
Isoforms & Proteins
7 transcripts · UniProt mapping is sequence-verified (AA-safe)
Each Ensembl transcript (ENST) this gene is mutated on, with its matched UniProt accession.
The mapping is sequence-verified: the UniProt sequence is identical to the transcript translation, so amino-acid positions line up exactly. A * marks an unreviewed (TrEMBL) entry.
Counts are mutations and unique mutant peptides on each transcript.
Gene Properties
Recurrent Mutations
All 559 amino-acid changes on canonical ENST00000356921 · needle height = samples · drag the mini-map to zoom
A lollipop / needle plot – the standard way to show recurrent mutations along a protein (as used by cBioPortal and MutationMapper).
X-axis = amino-acid position in the protein.
Needle height & head size = how often that exact amino-acid change was observed (its recurrence). Tall/large heads are mutational hotspots.
The most recurrent changes are labelled; hover any needle for the change, position and counts.
Mutation frequency across cancer types
% of samples with a missense/complex mutation in SLC8A3 · cell line vs tissue
For each cancer type, the fraction of samples that carry at least one missense/complex mutation anywhere in SLC8A3 – counted as distinct samples (a sample counts once no matter how many mutations it has).
Split into cell line and tissue; each cell shows mutated / total and the percentage. Cohorts with <20 samples are omitted. Ordered by combined frequency.
| Cancer type | Cell lines | Tissue samples |
|---|---|---|
| Melanoma | 29/210 14% | 172/1899 9% |
| T-Lymphoblastic Leukemia | 3/40 8% | 0/0 0% |
| Other Solid Cancers | 2/94 2% | 86/1515 6% |
| Endometrial Carcinoma | 6/42 14% | 27/612 4% |
| Non-Small Cell Lung Carcinoma | 33/304 11% | 49/1390 4% |
| Squamous Cell Lung Carcinoma | 3/57 5% | 33/810 4% |
| T-Cell Non-Hodgkins Lymphoma | 1/26 4% | 0/0 0% |
| Acute Myeloid Leukemia | 3/90 3% | 0/0 0% |
| Neuroendocrine Tumour | 21/154 14% | 3/577 1% |
| Unknown | 1/10 10% | 0/29 0% |
| Gastric Carcinoma | 3/74 4% | 40/1809 2% |
| Colorectal Carcinoma | 12/143 8% | 59/3239 2% |
| Small Cell Lung Carcinoma | 2/9 22% | 12/752 2% |
| Hodgkins Lymphoma | 1/16 6% | 1/122 1% |
| Burkitts Lymphoma | 3/32 9% | 0/196 0% |
| Other Sarcomas | 2/69 3% | 8/699 1% |
| Head and Neck Carcinoma | 1/85 1% | 20/1574 1% |
| Ovarian Carcinoma | 4/109 4% | 9/998 1% |
| Chondrosarcoma | 0/14 0% | 1/75 1% |
| Cervical Carcinoma | 2/35 6% | 3/422 1% |
| Glioblastoma | 1/98 1% | 0/0 0% |
| Pancreatic Carcinoma | 2/89 2% | 14/1611 1% |
| Bladder Carcinoma | 0/58 0% | 9/956 1% |
| Mesothelioma | 2/62 3% | 0/165 0% |
| Esophageal Squamous Cell Carcinoma | 6/51 12% | 17/2550 1% |
| Non-Cancerous | 0/104 0% | 8/830 1% |
| Hepatocellular Carcinoma | 1/46 2% | 14/2210 1% |
| Esophageal Carcinoma | 0/23 0% | 5/769 1% |
| Kidney Carcinoma | 2/85 2% | 10/1862 1% |
| Germ Cell Tumour | 1/25 4% | 0/169 0% |
Mutation Distribution
Where SLC8A3 is mutated · all tissues, split by cell line vs tissue
How many mutations in SLC8A3 were found in each tissue, across the whole database.
Each bar is a tissue (cell-line and tissue names are merged to the standard tissue), split into cell line and tissue (patient tumour) contributions.
This shows the cancer-context where this gene is recurrently altered.
GTEx Expression
Median TPM across 54 healthy tissues
Median gene expression (TPM) in normal, non-cancer human tissues from the GTEx project.
Useful for judging tumour specificity – a strong neoantigen target ideally comes from a gene with low expression in healthy tissues.
Scroll or drag the mini-axis below the chart to browse all tissues.
Mutations
All 3,729 mutations in SLC8A3
Every mutation record for this gene, across all samples and sources.
The Sample column links to the cell line (cell-line samples) or the tissue type (tissue samples).
Use the Type / Source filters, the search box, and column sorting to explore; each CAN-IMMUNE ID opens the full mutation & peptide view.
| ID | Sample | Transcript | AA Change | CDS | Type | Source | Mutant Peptide | Wild-type Peptide |
|---|