Stats by Source
Total, split by cell line (COSMIC CL / DepMap / PubMed) vs tissue (COSMIC primary tissue)
Total = all mutations for this gene across every source.
Cell line = COSMIC Cell Lines Project + DepMap + PubMed.
Tissue = COSMIC primary-tissue (patient tumour) samples.
Total can exceed cell line + tissue: COSMIC tissue-derived models sit only in global, and a peptide can be shared across both.
| Total | Cell line | Tissue | |
|---|---|---|---|
| Mutations | 776 | 49 | 727 |
| Samples | 80 | 8 | 72 |
| Peptides | 86 | 7 | 79 |
Function
SNCA · Synuclein alpha
Alpha-synuclein is a member of the synuclein family, which also includes beta- and gamma-synuclein. Synucleins are abundantly expressed in the brain and alpha- and beta-synuclein inhibit phospholipase D2 selectively. SNCA may serve to integrate presynaptic signaling and membrane trafficking. Defects in SNCA have been implicated in the pathogenesis of Parkinson disease. SNCA peptides are a major component of amyloid plaques in the brains of patients with Alzheimer's disease. Alternatively spliced transcripts encoding different isoforms have been identified for this gene. [provided by RefSeq, Feb 2016].
Isoforms & Proteins
12 transcripts · UniProt mapping is sequence-verified (AA-safe)
Each Ensembl transcript (ENST) this gene is mutated on, with its matched UniProt accession.
The mapping is sequence-verified: the UniProt sequence is identical to the transcript translation, so amino-acid positions line up exactly. A * marks an unreviewed (TrEMBL) entry.
Counts are mutations and unique mutant peptides on each transcript.
| Transcript | UniProt | Mutations | Peptides |
|---|---|---|---|
| ENST00000394991 | P37840 | 78 | 62 |
| ENST00000336904 | P37840 | 75 | 60 |
| ENST00000394986 | P37840 | 75 | 60 |
| ENST00000506244 | P37840 | 75 | 60 |
| ENST00000508895 | P37840 | 75 | 60 |
| ENST00000394989 | P37840-3 | 72 | 57 |
| ENST00000505199 | P37840-3 | 72 | 57 |
| ENST00000618500 | P37840-3 | 72 | 57 |
| ENST00000345009 | P37840-2 | 47 | 40 |
| ENST00000420646 | P37840-2 | 47 | 40 |
| ENST00000502987 | E7EPV7* | 44 | 37 |
| ENST00000611107 | A0A087WVQ5* | 44 | 37 |
Gene Properties
Recurrent Mutations
All 62 amino-acid changes on canonical ENST00000394991 · needle height = samples · drag the mini-map to zoom
A lollipop / needle plot – the standard way to show recurrent mutations along a protein (as used by cBioPortal and MutationMapper).
X-axis = amino-acid position in the protein.
Needle height & head size = how often that exact amino-acid change was observed (its recurrence). Tall/large heads are mutational hotspots.
The most recurrent changes are labelled; hover any needle for the change, position and counts.
Mutation frequency across cancer types
% of samples with a missense/complex mutation in SNCA · cell line vs tissue
For each cancer type, the fraction of samples that carry at least one missense/complex mutation anywhere in SNCA – counted as distinct samples (a sample counts once no matter how many mutations it has).
Split into cell line and tissue; each cell shows mutated / total and the percentage. Cohorts with <20 samples are omitted. Ordered by combined frequency.
| Cancer type | Cell lines | Tissue samples |
|---|---|---|
| Germ Cell Tumour | 0/25 0% | 2/169 1% |
| Endometrial Carcinoma | 0/42 0% | 6/612 1% |
| Squamous Cell Lung Carcinoma | 1/57 2% | 3/810 0% |
| Mesothelioma | 1/62 2% | 0/165 0% |
| Melanoma | 1/210 0% | 8/1899 0% |
| Other Solid Cancers | 0/94 0% | 6/1515 0% |
| Non-Small Cell Lung Carcinoma | 0/304 0% | 6/1390 0% |
| Gastric Carcinoma | 0/74 0% | 6/1809 0% |
| Ovarian Carcinoma | 2/109 2% | 1/998 0% |
| Small Cell Lung Carcinoma | 0/9 0% | 2/752 0% |
| Head and Neck Carcinoma | 0/85 0% | 4/1574 0% |
| Colorectal Carcinoma | 0/143 0% | 7/3239 0% |
| Neuroendocrine Tumour | 0/154 0% | 1/577 0% |
| Glioma | 0/52 0% | 3/2127 0% |
| Esophageal Carcinoma | 0/23 0% | 1/769 0% |
| Other Sarcomas | 0/69 0% | 1/699 0% |
| Thyroid Gland Carcinoma | 0/45 0% | 2/1592 0% |
| Breast Carcinoma | 2/144 1% | 2/3264 0% |
| B-Cell Non-Hodgkins Lymphoma | 0/88 0% | 3/2534 0% |
| Bladder Carcinoma | 0/58 0% | 1/956 0% |
| Hepatocellular Carcinoma | 0/46 0% | 2/2210 0% |
| Esophageal Squamous Cell Carcinoma | 0/51 0% | 2/2550 0% |
| Neuroblastoma | 0/87 0% | 1/1331 0% |
| Pancreatic Carcinoma | 0/89 0% | 1/1611 0% |
| Prostate Carcinoma | 0/13 0% | 1/2105 0% |
| Other Blood Cancers | 1/61 2% | 0/2725 0% |
Mutation Distribution
Where SNCA is mutated · all tissues, split by cell line vs tissue
How many mutations in SNCA were found in each tissue, across the whole database.
Each bar is a tissue (cell-line and tissue names are merged to the standard tissue), split into cell line and tissue (patient tumour) contributions.
This shows the cancer-context where this gene is recurrently altered.
GTEx Expression
Median TPM across 54 healthy tissues
Median gene expression (TPM) in normal, non-cancer human tissues from the GTEx project.
Useful for judging tumour specificity – a strong neoantigen target ideally comes from a gene with low expression in healthy tissues.
Scroll or drag the mini-axis below the chart to browse all tissues.
Mutations
All 776 mutations in SNCA
Every mutation record for this gene, across all samples and sources.
The Sample column links to the cell line (cell-line samples) or the tissue type (tissue samples).
Use the Type / Source filters, the search box, and column sorting to explore; each CAN-IMMUNE ID opens the full mutation & peptide view.
| ID | Sample | Transcript | AA Change | CDS | Type | Source | Mutant Peptide | Wild-type Peptide |
|---|