Stats by Source
Total, split by cell line (COSMIC CL / DepMap / PubMed) vs tissue (COSMIC primary tissue)
Total = all mutations for this gene across every source.
Cell line = COSMIC Cell Lines Project + DepMap + PubMed.
Tissue = COSMIC primary-tissue (patient tumour) samples.
Total can exceed cell line + tissue: COSMIC tissue-derived models sit only in global, and a peptide can be shared across both.
| Total | Cell line | Tissue | |
|---|---|---|---|
| Mutations | 1,886 | 247 | 1,619 |
| Samples | 490 | 90 | 392 |
| Peptides | 414 | 67 | 350 |
Function
SP100 · SP100 nuclear body protein
This gene encodes a subnuclear organelle and major component of the PML (promyelocytic leukemia)-SP100 nuclear bodies. PML and SP100 are covalently modified by the SUMO-1 modifier, which is considered crucial to nuclear body interactions. The encoded protein binds heterochromatin proteins and is thought to play a role in tumorigenesis, immunity, and gene regulation. Alternatively spliced variants have been identified for this gene; one of which encodes a high-mobility group protein. [provided by RefSeq, Aug 2011].
Isoforms & Proteins
7 transcripts · UniProt mapping is sequence-verified (AA-safe)
Each Ensembl transcript (ENST) this gene is mutated on, with its matched UniProt accession.
The mapping is sequence-verified: the UniProt sequence is identical to the transcript translation, so amino-acid positions line up exactly. A * marks an unreviewed (TrEMBL) entry.
Counts are mutations and unique mutant peptides on each transcript.
Gene Properties
Recurrent Mutations
All 328 amino-acid changes on canonical ENST00000340126 · needle height = samples · drag the mini-map to zoom
A lollipop / needle plot – the standard way to show recurrent mutations along a protein (as used by cBioPortal and MutationMapper).
X-axis = amino-acid position in the protein.
Needle height & head size = how often that exact amino-acid change was observed (its recurrence). Tall/large heads are mutational hotspots.
The most recurrent changes are labelled; hover any needle for the change, position and counts.
Mutation frequency across cancer types
% of samples with a missense/complex mutation in SP100 · cell line vs tissue
For each cancer type, the fraction of samples that carry at least one missense/complex mutation anywhere in SP100 – counted as distinct samples (a sample counts once no matter how many mutations it has).
Split into cell line and tissue; each cell shows mutated / total and the percentage. Cohorts with <20 samples are omitted. Ordered by combined frequency.
| Cancer type | Cell lines | Tissue samples |
|---|---|---|
| Endometrial Carcinoma | 1/42 2% | 34/612 6% |
| T-Lymphoblastic Leukemia | 2/40 5% | 0/0 0% |
| Acute Myeloid Leukemia | 4/90 4% | 0/0 0% |
| T-Cell Non-Hodgkins Lymphoma | 1/26 4% | 0/0 0% |
| Glioblastoma | 3/98 3% | 0/0 0% |
| Gastrointestinal Stromal Tumour | 0/0 0% | 4/133 3% |
| Melanoma | 7/210 3% | 50/1899 3% |
| Non-Small Cell Lung Carcinoma | 10/304 3% | 32/1390 2% |
| Cervical Carcinoma | 1/35 3% | 10/422 2% |
| Other Solid Cancers | 9/94 10% | 23/1515 2% |
| Bladder Carcinoma | 1/58 2% | 19/956 2% |
| Colorectal Carcinoma | 12/143 8% | 54/3239 2% |
| Gastric Carcinoma | 5/74 7% | 28/1809 2% |
| Germ Cell Tumour | 0/25 0% | 3/169 2% |
| Osteosarcoma | 3/45 7% | 0/166 0% |
| Mesothelioma | 3/62 5% | 0/165 0% |
| Neuroendocrine Tumour | 7/154 5% | 2/577 0% |
| Non-Cancerous | 1/104 1% | 10/830 1% |
| Squamous Cell Lung Carcinoma | 2/57 4% | 8/810 1% |
| Head and Neck Carcinoma | 0/85 0% | 16/1574 1% |
| Ewings Sarcoma | 3/63 5% | 0/262 0% |
| Ovarian Carcinoma | 1/109 1% | 9/998 1% |
| Burkitts Lymphoma | 2/32 6% | 0/196 0% |
| Hodgkins Lymphoma | 0/16 0% | 1/122 1% |
| Esophageal Squamous Cell Carcinoma | 0/51 0% | 18/2550 1% |
| Hepatocellular Carcinoma | 1/46 2% | 14/2210 1% |
| Glioma | 0/52 0% | 14/2127 1% |
| Rhabdomyosarcoma | 1/33 3% | 0/171 0% |
| Thyroid Gland Carcinoma | 2/45 4% | 6/1592 0% |
| Breast Carcinoma | 2/144 1% | 14/3264 0% |
Mutation Distribution
Where SP100 is mutated · all tissues, split by cell line vs tissue
How many mutations in SP100 were found in each tissue, across the whole database.
Each bar is a tissue (cell-line and tissue names are merged to the standard tissue), split into cell line and tissue (patient tumour) contributions.
This shows the cancer-context where this gene is recurrently altered.
GTEx Expression
Median TPM across 54 healthy tissues
Median gene expression (TPM) in normal, non-cancer human tissues from the GTEx project.
Useful for judging tumour specificity – a strong neoantigen target ideally comes from a gene with low expression in healthy tissues.
Scroll or drag the mini-axis below the chart to browse all tissues.
Mutations
All 1,886 mutations in SP100
Every mutation record for this gene, across all samples and sources.
The Sample column links to the cell line (cell-line samples) or the tissue type (tissue samples).
Use the Type / Source filters, the search box, and column sorting to explore; each CAN-IMMUNE ID opens the full mutation & peptide view.
| ID | Sample | Transcript | AA Change | CDS | Type | Source | Mutant Peptide | Wild-type Peptide |
|---|