ST3GAL3 ST3 beta-galactoside alpha-2,3-sialyltransferase 3 Q11203 SIAT6_HUMAN
Protein Coding Chr 1 1p34.1 Swiss-Prot reviewed Entrez 6487
Mutations
4,495
CL 485 · Tissue 3,911
Samples
227
CL 38 · Tissue 186
Peptides
295
unique mutant peptides
Transcripts
33
isoforms mutated

Stats by Source

Global, split by cell line (COSMIC CL / DepMap / PubMed) vs tissue (COSMIC primary tissue)

How the counts split by source
Stats by Source

Global = all mutations for this gene across every source.

Cell line = COSMIC Cell Lines Project + DepMap + PubMed.

Tissue = COSMIC primary-tissue (patient tumour) samples.

Global can exceed cell line + tissue: COSMIC tissue-derived models sit only in global, and a peptide can be shared across both.

GlobalCell lineTissue
Mutations4,4954853,911
Samples22738186
Peptides29544257

Function

ST3GAL3 · ST3 beta-galactoside alpha-2,3-sialyltransferase 3

The protein encoded by this gene is a type II membrane protein that catalyzes the transfer of sialic acid from CMP-sialic acid to galactose-containing substrates. The encoded protein is normally found in the Golgi apparatus but can be proteolytically processed to a soluble form. This protein is a member of glycosyltransferase family 29. Mutations in this gene have been associated with a form of autosomal recessive nonsymdromic cognitive disability as well as infantile epileptic encephalopathy. Multiple transcript variants encoding several different isoforms have been found for this gene. [provided by RefSeq, Jul 2017].

Isoforms & Proteins

33 transcripts · UniProt mapping is sequence-verified (AA-safe)

About the isoform mapping
Isoforms & Proteins

Each Ensembl transcript (ENST) this gene is mutated on, with its matched UniProt accession.

The mapping is sequence-verified: the UniProt sequence is identical to the transcript translation, so amino-acid positions line up exactly. A * marks an unreviewed (TrEMBL) entry.

Counts are mutations and unique mutant peptides on each transcript.

TranscriptUniProtMutationsPeptides
ENST00000262915 Q11203-4 203 145
ENST00000351035 Q11203-13 200 142
ENST00000347631 Q11203 193 134
ENST00000372372 Q11203-19 193 137
ENST00000642331 A0A2R8YDJ6* 180 134
ENST00000372368 A0A2U3TZM2* 178 129
ENST00000361392 Q11203-2 177 130
ENST00000643252 A0A2R8Y6H4* 177 131
ENST00000647148 A0A2R8Y7D8* 176 130
ENST00000361746 A0A2U3TZK9* 174 127
ENST00000644195 Q11203 174 127
ENST00000646971 Q11203 174 127
ENST00000646686 A0A2R8Y732* 170 126
ENST00000361400 Q11203-15 167 122
ENST00000372369 Q11203-5 166 120
ENST00000647237 A0A2R8Y6L4* 164 116
ENST00000645034 A0A2R8Y7Z2* 161 119
ENST00000372374 Q11203-7 158 115
ENST00000353126 Q11203-8 138 101
ENST00000642934 Q11203-16 131 96
ENST00000531993 Q11203-21 115 84
ENST00000372367 Q11203-24 106 78
ENST00000528371 Q11203-17 104 76
ENST00000372365 Q11203-10 94 68
ENST00000335430 Q11203-23 89 65
ENST00000372366 Q11203-23 89 65
ENST00000361812 Q11203-3 82 61
ENST00000545417 Q11203-3 82 61
ENST00000372362 Q11203-12 79 58
ENST00000531451 Q11203-18 72 53
ENST00000330208 Q11203-22 55 40
ENST00000531816 Q11203-22 55 40
ENST00000484868 A0A2R8Y7D5* 19 14

Gene Properties

Type
Protein Coding
Chromosome
1
Cytoband
1p34.1
Entrez ID
6487
Aliases
DEE15EIEE15MRT12SIAT6ST3GALIIST3Gal III

Recurrent Mutations

Top recurrent amino-acid changes along the protein · needle height = number of mutations

What this lollipop shows
Recurrent Mutations

A lollipop / needle plot – the standard way to show recurrent mutations along a protein (as used by cBioPortal and MutationMapper).

X-axis = amino-acid position in the protein.

Needle height & head size = how often that exact amino-acid change was observed (its recurrence). Tall/large heads are mutational hotspots.

The most recurrent changes are labelled; hover any needle for the change, position and counts.

Mutation Distribution

Where ST3GAL3 is mutated · all tissues, split by cell line vs tissue

Mutation counts by tissue
Mutation Distribution

How many mutations in ST3GAL3 were found in each tissue, across the whole database.

Each bar is a tissue (cell-line and tissue names are merged to the standard tissue), split into cell line and tissue (patient tumour) contributions.

This shows the cancer-context where this gene is recurrently altered.

GTEx Expression

Median TPM across 54 healthy tissues

GTEx Portal ↗
About the expression data
GTEx Expression

Median gene expression (TPM) in normal, non-cancer human tissues from the GTEx project.

Useful for judging tumour specificity – a strong neoantigen target ideally comes from a gene with low expression in healthy tissues.

Scroll or drag the mini-axis below the chart to browse all tissues.

Mutations

All 4,495 mutations in ST3GAL3

About the mutation list
Mutations

Every mutation record for this gene, across all samples and sources.

The Sample column links to the cell line (cell-line samples) or the tissue type (tissue samples).

Use the Type / Source filters, the search box, and column sorting to explore; each CAN-IMMUNE ID opens the full mutation & peptide view.

IDSampleTranscriptAA Change CDSTypeSourcePeptide