Stats by Source
Total, split by cell line (COSMIC CL / DepMap / PubMed) vs tissue (COSMIC primary tissue)
Total = all mutations for this gene across every source.
Cell line = COSMIC Cell Lines Project + DepMap + PubMed.
Tissue = COSMIC primary-tissue (patient tumour) samples.
Total can exceed cell line + tissue: COSMIC tissue-derived models sit only in global, and a peptide can be shared across both.
| Total | Cell line | Tissue | |
|---|---|---|---|
| Mutations | 296 | 34 | 259 |
| Samples | 151 | 24 | 125 |
| Peptides | 108 | 14 | 95 |
Function
STARD6 · StAR related lipid transfer domain containing 6
Cholesterol homeostasis is regulated, at least in part, by sterol regulatory element (SRE)-binding proteins (e.g., SREBP1; MIM 184756) and by liver X receptors (e.g., LXRA; MIM 602423). Upon sterol depletion, LXRs are inactive and SREBPs are cleaved, after which they bind promoter SREs and activate genes involved in cholesterol biosynthesis and uptake. Sterol transport is mediated by vesicles or by soluble protein carriers, such as steroidogenic acute regulatory protein (STAR; MIM 600617). STAR is homologous to a family of proteins containing a 200- to 210-amino acid STAR-related lipid transfer (START) domain, including STARD6 (Soccio et al., 2002 [PubMed 12011452]).[supplied by OMIM, Mar 2008].
Isoforms & Proteins
4 transcripts · UniProt mapping is sequence-verified (AA-safe)
Each Ensembl transcript (ENST) this gene is mutated on, with its matched UniProt accession.
The mapping is sequence-verified: the UniProt sequence is identical to the transcript translation, so amino-acid positions line up exactly. A * marks an unreviewed (TrEMBL) entry.
Counts are mutations and unique mutant peptides on each transcript.
| Transcript | UniProt | Mutations | Peptides |
|---|---|---|---|
| ENST00000307844 | P59095 | 152 | 105 |
| ENST00000581310 | P59095 | 136 | 99 |
| ENST00000584040 | J3QRT9* | 7 | 6 |
| ENST00000686109 | A0A8I5QL07* | 1 | 1 |
Gene Properties
Recurrent Mutations
All 105 amino-acid changes on canonical ENST00000307844 · needle height = samples · drag the mini-map to zoom
A lollipop / needle plot – the standard way to show recurrent mutations along a protein (as used by cBioPortal and MutationMapper).
X-axis = amino-acid position in the protein.
Needle height & head size = how often that exact amino-acid change was observed (its recurrence). Tall/large heads are mutational hotspots.
The most recurrent changes are labelled; hover any needle for the change, position and counts.
Mutation frequency across cancer types
% of samples with a missense/complex mutation in STARD6 · cell line vs tissue
For each cancer type, the fraction of samples that carry at least one missense/complex mutation anywhere in STARD6 – counted as distinct samples (a sample counts once no matter how many mutations it has).
Split into cell line and tissue; each cell shows mutated / total and the percentage. Cohorts with <20 samples are omitted. Ordered by combined frequency.
| Cancer type | Cell lines | Tissue samples |
|---|---|---|
| Endometrial Carcinoma | 6/42 14% | 6/612 1% |
| Melanoma | 0/210 0% | 38/1899 2% |
| Germ Cell Tumour | 1/25 4% | 1/169 1% |
| Other Solid Cancers | 0/94 0% | 11/1515 1% |
| Squamous Cell Lung Carcinoma | 0/57 0% | 5/810 1% |
| Colorectal Carcinoma | 2/143 1% | 17/3239 1% |
| Small Cell Lung Carcinoma | 0/9 0% | 4/752 1% |
| Osteosarcoma | 1/45 2% | 0/166 0% |
| Cervical Carcinoma | 0/35 0% | 2/422 0% |
| Non-Small Cell Lung Carcinoma | 5/304 2% | 2/1390 0% |
| Glioma | 3/52 6% | 6/2127 0% |
| Biliary Tract Carcinoma | 0/54 0% | 4/950 0% |
| Ovarian Carcinoma | 2/109 2% | 2/998 0% |
| Bladder Carcinoma | 0/58 0% | 3/956 0% |
| Plasma Cell Myeloma | 0/44 0% | 1/305 0% |
| Gastric Carcinoma | 0/74 0% | 5/1809 0% |
| Pancreatic Carcinoma | 0/89 0% | 3/1611 0% |
| Kidney Carcinoma | 0/85 0% | 3/1862 0% |
| Neuroendocrine Tumour | 0/154 0% | 1/577 0% |
| Esophageal Carcinoma | 0/23 0% | 1/769 0% |
| Hepatocellular Carcinoma | 0/46 0% | 3/2210 0% |
| Other Sarcomas | 1/69 1% | 0/699 0% |
| Breast Carcinoma | 1/144 1% | 3/3264 0% |
| Esophageal Squamous Cell Carcinoma | 0/51 0% | 3/2550 0% |
| B-Lymphoblastic Leukemia | 0/55 0% | 3/2640 0% |
| Non-Cancerous | 1/104 1% | 0/830 0% |
| B-Cell Non-Hodgkins Lymphoma | 1/88 1% | 0/2534 0% |
Mutation Distribution
Where STARD6 is mutated · all tissues, split by cell line vs tissue
How many mutations in STARD6 were found in each tissue, across the whole database.
Each bar is a tissue (cell-line and tissue names are merged to the standard tissue), split into cell line and tissue (patient tumour) contributions.
This shows the cancer-context where this gene is recurrently altered.
GTEx Expression
Median TPM across 33 healthy tissues
Median gene expression (TPM) in normal, non-cancer human tissues from the GTEx project.
Useful for judging tumour specificity – a strong neoantigen target ideally comes from a gene with low expression in healthy tissues.
Scroll or drag the mini-axis below the chart to browse all tissues.
Mutations
All 296 mutations in STARD6
Every mutation record for this gene, across all samples and sources.
The Sample column links to the cell line (cell-line samples) or the tissue type (tissue samples).
Use the Type / Source filters, the search box, and column sorting to explore; each CAN-IMMUNE ID opens the full mutation & peptide view.
| ID | Sample | Transcript | AA Change | CDS | Type | Source | Mutant Peptide | Wild-type Peptide |
|---|