Stats by Source
Total, split by cell line (COSMIC CL / DepMap / PubMed) vs tissue (COSMIC primary tissue)
Total = all mutations for this gene across every source.
Cell line = COSMIC Cell Lines Project + DepMap + PubMed.
Tissue = COSMIC primary-tissue (patient tumour) samples.
Total can exceed cell line + tissue: COSMIC tissue-derived models sit only in global, and a peptide can be shared across both.
| Total | Cell line | Tissue | |
|---|---|---|---|
| Mutations | 780 | 113 | 662 |
| Samples | 262 | 57 | 201 |
| Peptides | 222 | 36 | 185 |
Function
STIP1 · Stress induced phosphoprotein 1
STIP1 is an adaptor protein that coordinates the functions of HSP70 (see HSPA1A; MIM 140550) and HSP90 (see HSP90AA1; MIM 140571) in protein folding. It is thought to assist in the transfer of proteins from HSP70 to HSP90 by binding both HSP90 and substrate-bound HSP70. STIP1 also stimulates the ATPase activity of HSP70 and inhibits the ATPase activity of HSP90, suggesting that it regulates both the conformations and ATPase cycles of these chaperones (Song and Masison, 2005 [PubMed 16100115]).[supplied by OMIM, Jul 2009].
Isoforms & Proteins
4 transcripts · UniProt mapping is sequence-verified (AA-safe)
Each Ensembl transcript (ENST) this gene is mutated on, with its matched UniProt accession.
The mapping is sequence-verified: the UniProt sequence is identical to the transcript translation, so amino-acid positions line up exactly. A * marks an unreviewed (TrEMBL) entry.
Counts are mutations and unique mutant peptides on each transcript.
Gene Properties
Recurrent Mutations
All 195 amino-acid changes on canonical ENST00000305218 · needle height = samples · drag the mini-map to zoom
A lollipop / needle plot – the standard way to show recurrent mutations along a protein (as used by cBioPortal and MutationMapper).
X-axis = amino-acid position in the protein.
Needle height & head size = how often that exact amino-acid change was observed (its recurrence). Tall/large heads are mutational hotspots.
The most recurrent changes are labelled; hover any needle for the change, position and counts.
Mutation frequency across cancer types
% of samples with a missense/complex mutation in STIP1 · cell line vs tissue
For each cancer type, the fraction of samples that carry at least one missense/complex mutation anywhere in STIP1 – counted as distinct samples (a sample counts once no matter how many mutations it has).
Split into cell line and tissue; each cell shows mutated / total and the percentage. Cohorts with <20 samples are omitted. Ordered by combined frequency.
| Cancer type | Cell lines | Tissue samples |
|---|---|---|
| T-Lymphoblastic Leukemia | 4/40 10% | 0/0 0% |
| Endometrial Carcinoma | 6/42 14% | 17/612 3% |
| Germ Cell Tumour | 2/25 8% | 1/169 1% |
| Squamous Cell Lung Carcinoma | 3/57 5% | 9/810 1% |
| Melanoma | 2/210 1% | 26/1899 1% |
| Neuroendocrine Tumour | 7/154 5% | 2/577 0% |
| Bladder Carcinoma | 0/58 0% | 10/956 1% |
| Colorectal Carcinoma | 7/143 5% | 26/3239 1% |
| Gastric Carcinoma | 0/74 0% | 18/1809 1% |
| Non-Small Cell Lung Carcinoma | 8/304 3% | 8/1390 1% |
| Cervical Carcinoma | 1/35 3% | 3/422 1% |
| Other Solid Cancers | 3/94 3% | 10/1515 1% |
| Gastrointestinal Stromal Tumour | 0/0 0% | 1/133 1% |
| Esophageal Squamous Cell Carcinoma | 0/51 0% | 15/2550 1% |
| Small Cell Lung Carcinoma | 0/9 0% | 4/752 1% |
| Non-Cancerous | 0/104 0% | 4/830 0% |
| Head and Neck Carcinoma | 1/85 1% | 6/1574 0% |
| Hepatocellular Carcinoma | 1/46 2% | 8/2210 0% |
| Biliary Tract Carcinoma | 0/54 0% | 3/950 0% |
| Glioma | 0/52 0% | 6/2127 0% |
| Ovarian Carcinoma | 0/109 0% | 3/998 0% |
| Breast Carcinoma | 0/144 0% | 9/3264 0% |
| Other Sarcomas | 2/69 3% | 0/699 0% |
| Esophageal Carcinoma | 0/23 0% | 2/769 0% |
| Thyroid Gland Carcinoma | 0/45 0% | 4/1592 0% |
| Prostate Carcinoma | 1/13 8% | 4/2105 0% |
| B-Lymphoblastic Leukemia | 5/55 9% | 0/2640 0% |
| Pancreatic Carcinoma | 1/89 1% | 2/1611 0% |
| Other Blood Cancers | 2/61 3% | 2/2725 0% |
| Kidney Carcinoma | 1/85 1% | 1/1862 0% |
Mutation Distribution
Where STIP1 is mutated · all tissues, split by cell line vs tissue
How many mutations in STIP1 were found in each tissue, across the whole database.
Each bar is a tissue (cell-line and tissue names are merged to the standard tissue), split into cell line and tissue (patient tumour) contributions.
This shows the cancer-context where this gene is recurrently altered.
GTEx Expression
Median TPM across 54 healthy tissues
Median gene expression (TPM) in normal, non-cancer human tissues from the GTEx project.
Useful for judging tumour specificity – a strong neoantigen target ideally comes from a gene with low expression in healthy tissues.
Scroll or drag the mini-axis below the chart to browse all tissues.
Mutations
All 780 mutations in STIP1
Every mutation record for this gene, across all samples and sources.
The Sample column links to the cell line (cell-line samples) or the tissue type (tissue samples).
Use the Type / Source filters, the search box, and column sorting to explore; each CAN-IMMUNE ID opens the full mutation & peptide view.
| ID | Sample | Transcript | AA Change | CDS | Type | Source | Mutant Peptide | Wild-type Peptide |
|---|