Stats by Source
Global, split by cell line (COSMIC CL / DepMap / PubMed) vs tissue (COSMIC primary tissue)
Global = all mutations for this gene across every source.
Cell line = COSMIC Cell Lines Project + DepMap + PubMed.
Tissue = COSMIC primary-tissue (patient tumour) samples.
Global can exceed cell line + tissue: COSMIC tissue-derived models sit only in global, and a peptide can be shared across both.
| Global | Cell line | Tissue | |
|---|---|---|---|
| Mutations | 2,624 | 334 | 2,265 |
| Samples | 173 | 32 | 139 |
| Peptides | 195 | 32 | 167 |
Function
STRADA · STE20 related adaptor alpha
The protein encoded by this gene contains a STE20-like kinase domain, but lacks several residues that are critical for catalytic activity, so it is termed a 'pseudokinase'. The protein forms a heterotrimeric complex with serine/threonine kinase 11 (STK11, also known as LKB1) and the scaffolding protein calcium binding protein 39 (CAB39, also known as MO25). The protein activates STK11 leading to the phosphorylation of both proteins and excluding STK11 from the nucleus. The protein is necessary for STK11-induced G1 cell cycle arrest. A mutation in this gene has been shown to result in polyhydramnios, megalencephaly, and symptomatic epilepsy (PMSE) syndrome. Multiple transcript variants encoding different isoforms have been found for this gene. Additional transcript variants have been described but their full-length nature is not known. [provided by RefSeq, Sep 2009].
Isoforms & Proteins
23 transcripts · UniProt mapping is sequence-verified (AA-safe)
Each Ensembl transcript (ENST) this gene is mutated on, with its matched UniProt accession.
The mapping is sequence-verified: the UniProt sequence is identical to the transcript translation, so amino-acid positions line up exactly. A * marks an unreviewed (TrEMBL) entry.
Counts are mutations and unique mutant peptides on each transcript.
| Transcript | UniProt | Mutations | Peptides |
|---|---|---|---|
| ENST00000336174 | Q7RTN6 | 165 | 124 |
| ENST00000638193 | A0A1W2PQF1* | 145 | 118 |
| ENST00000638708 | A0A1W2PPJ9* | 141 | 114 |
| ENST00000639835 | Q7RTN6-3 | 141 | 114 |
| ENST00000640999 | Q7RTN6-3 | 141 | 114 |
| ENST00000375840 | Q7RTN6-5 | 134 | 109 |
| ENST00000638702 | Q7RTN6-5 | 134 | 109 |
| ENST00000392950 | Q7RTN6-2 | 132 | 109 |
| ENST00000640979 | A0A1W2PPM8* | 130 | 106 |
| ENST00000638888 | A0A1W2PPG2* | 124 | 101 |
| ENST00000582137 | Q7RTN6-6 | 116 | 94 |
| ENST00000640086 | A0A1W2PR00* | 116 | 94 |
| ENST00000447001 | Q7RTN6-4 | 112 | 91 |
| ENST00000638698 | A0A1W2PNV7* | 111 | 88 |
| ENST00000640679 | A0A1W2PNV7* | 111 | 88 |
| ENST00000638276 | A0A1W2PQE8* | 109 | 89 |
| ENST00000638309 | A0A1W2PS04* | 99 | 80 |
| ENST00000578008 | J3QS66* | 91 | 73 |
| ENST00000245865 | A0ACM8PXG4* | 84 | 68 |
| ENST00000617949 | A0ACM8PXG4* | 84 | 68 |
| ENST00000640397 | A0A1W2PRQ6* | 81 | 65 |
| ENST00000578801 | J3QQS3* | 69 | 57 |
| ENST00000579340 | J3KSK5* | 54 | 45 |
Gene Properties
Recurrent Mutations
Top recurrent amino-acid changes along the protein · needle height = number of mutations
A lollipop / needle plot – the standard way to show recurrent mutations along a protein (as used by cBioPortal and MutationMapper).
X-axis = amino-acid position in the protein.
Needle height & head size = how often that exact amino-acid change was observed (its recurrence). Tall/large heads are mutational hotspots.
The most recurrent changes are labelled; hover any needle for the change, position and counts.
Mutation Distribution
Where STRADA is mutated · all tissues, split by cell line vs tissue
How many mutations in STRADA were found in each tissue, across the whole database.
Each bar is a tissue (cell-line and tissue names are merged to the standard tissue), split into cell line and tissue (patient tumour) contributions.
This shows the cancer-context where this gene is recurrently altered.
GTEx Expression
Median TPM across 54 healthy tissues
Median gene expression (TPM) in normal, non-cancer human tissues from the GTEx project.
Useful for judging tumour specificity – a strong neoantigen target ideally comes from a gene with low expression in healthy tissues.
Scroll or drag the mini-axis below the chart to browse all tissues.
Mutations
All 2,624 mutations in STRADA
Every mutation record for this gene, across all samples and sources.
The Sample column links to the cell line (cell-line samples) or the tissue type (tissue samples).
Use the Type / Source filters, the search box, and column sorting to explore; each CAN-IMMUNE ID opens the full mutation & peptide view.
| ID | Sample | Transcript | AA Change | CDS | Type | Source | Peptide |
|---|