Stats by Source
Total, split by cell line (COSMIC CL / DepMap / PubMed) vs tissue (COSMIC primary tissue)
Total = all mutations for this gene across every source.
Cell line = COSMIC Cell Lines Project + DepMap + PubMed.
Tissue = COSMIC primary-tissue (patient tumour) samples.
Total can exceed cell line + tissue: COSMIC tissue-derived models sit only in global, and a peptide can be shared across both.
| Total | Cell line | Tissue | |
|---|---|---|---|
| Mutations | 11,709 | 1,214 | 10,405 |
| Samples | 1,338 | 254 | 1,063 |
| Peptides | 1,278 | 201 | 1,089 |
Function
TACC2 · Transforming acidic coiled-coil containing protein 2
Transforming acidic coiled-coil proteins are a conserved family of centrosome- and microtubule-interacting proteins that are implicated in cancer. This gene encodes a protein that concentrates at centrosomes throughout the cell cycle. This gene lies within a chromosomal region associated with tumorigenesis. Expression of this gene is induced by erythropoietin and is thought to affect the progression of breast tumors. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008].
Isoforms & Proteins
13 transcripts · UniProt mapping is sequence-verified (AA-safe)
Each Ensembl transcript (ENST) this gene is mutated on, with its matched UniProt accession.
The mapping is sequence-verified: the UniProt sequence is identical to the transcript translation, so amino-acid positions line up exactly. A * marks an unreviewed (TrEMBL) entry.
Counts are mutations and unique mutant peptides on each transcript.
| Transcript | UniProt | Mutations | Peptides |
|---|---|---|---|
| ENST00000369005 | O95359 | 1,709 | 1,189 |
| ENST00000334433 | O95359 | 1,538 | 1,122 |
| ENST00000453444 | E9PBC6* | 1,481 | 1,079 |
| ENST00000515273 | E9PBC6* | 1,481 | 1,079 |
| ENST00000515603 | E7EMZ9* | 1,466 | 1,068 |
| ENST00000358010 | O95359-5 | 603 | 404 |
| ENST00000513429 | O95359-5 | 603 | 404 |
| ENST00000368999 | Q4VXL8* | 568 | 377 |
| ENST00000260733 | O95359-1 | 566 | 375 |
| ENST00000369004 | D6RAA5* | 554 | 366 |
| ENST00000360561 | O95359-6 | 552 | 364 |
| ENST00000369001 | Q4VXL4* | 295 | 205 |
| ENST00000369000 | O95359-2 | 293 | 203 |
Gene Properties
Recurrent Mutations
All 1189 amino-acid changes on canonical ENST00000369005 · needle height = samples · drag the mini-map to zoom
A lollipop / needle plot – the standard way to show recurrent mutations along a protein (as used by cBioPortal and MutationMapper).
X-axis = amino-acid position in the protein.
Needle height & head size = how often that exact amino-acid change was observed (its recurrence). Tall/large heads are mutational hotspots.
The most recurrent changes are labelled; hover any needle for the change, position and counts.
Mutation frequency across cancer types
% of samples with a missense/complex mutation in TACC2 · cell line vs tissue
For each cancer type, the fraction of samples that carry at least one missense/complex mutation anywhere in TACC2 – counted as distinct samples (a sample counts once no matter how many mutations it has).
Split into cell line and tissue; each cell shows mutated / total and the percentage. Cohorts with <20 samples are omitted. Ordered by combined frequency.
| Cancer type | Cell lines | Tissue samples |
|---|---|---|
| T-Lymphoblastic Leukemia | 12/40 30% | 0/0 0% |
| Melanoma | 19/210 9% | 274/1899 14% |
| Chronic Myelogenous Leukemia | 3/25 12% | 0/0 0% |
| Endometrial Carcinoma | 15/42 36% | 40/612 7% |
| Oral Cavity Carcinoma | 3/54 6% | 0/0 0% |
| Non-Small Cell Lung Carcinoma | 37/304 12% | 55/1390 4% |
| Hodgkins Lymphoma | 4/16 25% | 3/122 2% |
| Gastrointestinal Stromal Tumour | 0/0 0% | 6/133 5% |
| Other Solid Cancers | 7/94 7% | 61/1515 4% |
| Cervical Carcinoma | 0/35 0% | 19/422 4% |
| Colorectal Carcinoma | 30/143 21% | 107/3239 3% |
| Gastric Carcinoma | 3/74 4% | 72/1809 4% |
| Bladder Carcinoma | 4/58 7% | 35/956 4% |
| Germ Cell Tumour | 3/25 12% | 4/169 2% |
| Rhabdomyosarcoma | 1/33 3% | 6/171 4% |
| Ovarian Carcinoma | 12/109 11% | 26/998 3% |
| Acute Myeloid Leukemia | 3/90 3% | 0/0 0% |
| Osteosarcoma | 6/45 13% | 0/166 0% |
| Plasma Cell Myeloma | 2/44 5% | 7/305 2% |
| Biliary Tract Carcinoma | 5/54 9% | 17/950 2% |
| Head and Neck Carcinoma | 5/85 6% | 30/1574 2% |
| Squamous Cell Lung Carcinoma | 4/57 7% | 14/810 2% |
| Non-Cancerous | 1/104 1% | 18/830 2% |
| Hepatocellular Carcinoma | 6/46 13% | 35/2210 2% |
| Neuroendocrine Tumour | 6/154 4% | 7/577 1% |
| Burkitts Lymphoma | 4/32 12% | 0/196 0% |
| Esophageal Squamous Cell Carcinoma | 6/51 12% | 39/2550 2% |
| Thyroid Gland Carcinoma | 2/45 4% | 20/1592 1% |
| Glioma | 1/52 2% | 28/2127 1% |
| Small Cell Lung Carcinoma | 0/9 0% | 10/752 1% |
Mutation Distribution
Where TACC2 is mutated · all tissues, split by cell line vs tissue
How many mutations in TACC2 were found in each tissue, across the whole database.
Each bar is a tissue (cell-line and tissue names are merged to the standard tissue), split into cell line and tissue (patient tumour) contributions.
This shows the cancer-context where this gene is recurrently altered.
GTEx Expression
Median TPM across 54 healthy tissues
Median gene expression (TPM) in normal, non-cancer human tissues from the GTEx project.
Useful for judging tumour specificity – a strong neoantigen target ideally comes from a gene with low expression in healthy tissues.
Scroll or drag the mini-axis below the chart to browse all tissues.
Mutations
All 11,709 mutations in TACC2
Every mutation record for this gene, across all samples and sources.
The Sample column links to the cell line (cell-line samples) or the tissue type (tissue samples).
Use the Type / Source filters, the search box, and column sorting to explore; each CAN-IMMUNE ID opens the full mutation & peptide view.
| ID | Sample | Transcript | AA Change | CDS | Type | Source | Mutant Peptide | Wild-type Peptide |
|---|