Stats by Source
Total, split by cell line (COSMIC CL / DepMap / PubMed) vs tissue (COSMIC primary tissue)
Total = all mutations for this gene across every source.
Cell line = COSMIC Cell Lines Project + DepMap + PubMed.
Tissue = COSMIC primary-tissue (patient tumour) samples.
Total can exceed cell line + tissue: COSMIC tissue-derived models sit only in global, and a peptide can be shared across both.
| Total | Cell line | Tissue | |
|---|---|---|---|
| Mutations | 1,930 | 156 | 1,687 |
| Samples | 294 | 45 | 242 |
| Peptides | 235 | 35 | 201 |
Function
TBL1X · Transducin beta like 1 X-linked
The protein encoded by this gene has sequence similarity with members of the WD40 repeat-containing protein family. The WD40 group is a large family of proteins, which appear to have a regulatory function. It is believed that the WD40 repeats mediate protein-protein interactions and members of the family are involved in signal transduction, RNA processing, gene regulation, vesicular trafficking, cytoskeletal assembly and may play a role in the control of cytotypic differentiation. This encoded protein is found as a subunit in corepressor SMRT (silencing mediator for retinoid and thyroid receptors) complex along with histone deacetylase 3 protein. This gene is located adjacent to the ocular albinism gene and it is thought to be involved in the pathogenesis of the ocular albinism with late-onset sensorineural deafness phenotype. Four transcript variants encoding two different isoforms have been found for this gene. This gene is highly similar to the Y chromosome TBL1Y gene. [provided by RefSeq, Nov 2008].
Isoforms & Proteins
7 transcripts · UniProt mapping is sequence-verified (AA-safe)
Each Ensembl transcript (ENST) this gene is mutated on, with its matched UniProt accession.
The mapping is sequence-verified: the UniProt sequence is identical to the transcript translation, so amino-acid positions line up exactly. A * marks an unreviewed (TrEMBL) entry.
Counts are mutations and unique mutant peptides on each transcript.
Gene Properties
Recurrent Mutations
All 223 amino-acid changes on canonical ENST00000645353 · needle height = samples · drag the mini-map to zoom
A lollipop / needle plot – the standard way to show recurrent mutations along a protein (as used by cBioPortal and MutationMapper).
X-axis = amino-acid position in the protein.
Needle height & head size = how often that exact amino-acid change was observed (its recurrence). Tall/large heads are mutational hotspots.
The most recurrent changes are labelled; hover any needle for the change, position and counts.
Mutation frequency across cancer types
% of samples with a missense/complex mutation in TBL1X · cell line vs tissue
For each cancer type, the fraction of samples that carry at least one missense/complex mutation anywhere in TBL1X – counted as distinct samples (a sample counts once no matter how many mutations it has).
Split into cell line and tissue; each cell shows mutated / total and the percentage. Cohorts with <20 samples are omitted. Ordered by combined frequency.
| Cancer type | Cell lines | Tissue samples |
|---|---|---|
| T-Lymphoblastic Leukemia | 3/40 8% | 0/0 0% |
| Chronic Myelogenous Leukemia | 1/25 4% | 0/0 0% |
| Endometrial Carcinoma | 3/42 7% | 16/612 3% |
| Oral Cavity Carcinoma | 1/54 2% | 0/0 0% |
| Gastric Carcinoma | 1/74 1% | 26/1809 1% |
| Colorectal Carcinoma | 7/143 5% | 41/3239 1% |
| Melanoma | 0/210 0% | 29/1899 2% |
| Glioblastoma | 1/98 1% | 0/0 0% |
| Other Solid Cancers | 2/94 2% | 12/1515 1% |
| Ovarian Carcinoma | 5/109 5% | 4/998 0% |
| Biliary Tract Carcinoma | 2/54 4% | 6/950 1% |
| Non-Cancerous | 1/104 1% | 6/830 1% |
| Gastrointestinal Stromal Tumour | 0/0 0% | 1/133 1% |
| Neuroendocrine Tumour | 3/154 2% | 2/577 0% |
| Head and Neck Carcinoma | 0/85 0% | 11/1574 1% |
| Non-Small Cell Lung Carcinoma | 2/304 1% | 9/1390 1% |
| Thyroid Gland Carcinoma | 0/45 0% | 10/1592 1% |
| Other Sarcomas | 2/69 3% | 2/699 0% |
| Kidney Carcinoma | 1/85 1% | 8/1862 0% |
| Hepatocellular Carcinoma | 1/46 2% | 9/2210 0% |
| Cervical Carcinoma | 0/35 0% | 2/422 0% |
| Small Cell Lung Carcinoma | 0/9 0% | 3/752 0% |
| Bladder Carcinoma | 0/58 0% | 4/956 0% |
| Breast Carcinoma | 3/144 2% | 10/3264 0% |
| Glioma | 2/52 4% | 6/2127 0% |
| Esophageal Squamous Cell Carcinoma | 0/51 0% | 9/2550 0% |
| Squamous Cell Lung Carcinoma | 0/57 0% | 3/810 0% |
| Ewings Sarcoma | 1/63 2% | 0/262 0% |
| B-Cell Non-Hodgkins Lymphoma | 2/88 2% | 6/2534 0% |
| Pancreatic Carcinoma | 0/89 0% | 4/1611 0% |
Mutation Distribution
Where TBL1X is mutated · all tissues, split by cell line vs tissue
How many mutations in TBL1X were found in each tissue, across the whole database.
Each bar is a tissue (cell-line and tissue names are merged to the standard tissue), split into cell line and tissue (patient tumour) contributions.
This shows the cancer-context where this gene is recurrently altered.
GTEx Expression
Median TPM across 54 healthy tissues
Median gene expression (TPM) in normal, non-cancer human tissues from the GTEx project.
Useful for judging tumour specificity – a strong neoantigen target ideally comes from a gene with low expression in healthy tissues.
Scroll or drag the mini-axis below the chart to browse all tissues.
Mutations
All 1,930 mutations in TBL1X
Every mutation record for this gene, across all samples and sources.
The Sample column links to the cell line (cell-line samples) or the tissue type (tissue samples).
Use the Type / Source filters, the search box, and column sorting to explore; each CAN-IMMUNE ID opens the full mutation & peptide view.
| ID | Sample | Transcript | AA Change | CDS | Type | Source | Mutant Peptide | Wild-type Peptide |
|---|