Stats by Source
Total, split by cell line (COSMIC CL / DepMap / PubMed) vs tissue (COSMIC primary tissue)
Total = all mutations for this gene across every source.
Cell line = COSMIC Cell Lines Project + DepMap + PubMed.
Tissue = COSMIC primary-tissue (patient tumour) samples.
Total can exceed cell line + tissue: COSMIC tissue-derived models sit only in global, and a peptide can be shared across both.
| Total | Cell line | Tissue | |
|---|---|---|---|
| Mutations | 2,139 | 244 | 1,857 |
| Samples | 643 | 110 | 522 |
| Peptides | 524 | 77 | 454 |
Function
TEK · TEK receptor tyrosine kinase
This gene encodes a receptor that belongs to the protein tyrosine kinase Tie2 family. The encoded protein possesses a unique extracellular region that contains two immunoglobulin-like domains, three epidermal growth factor (EGF)-like domains and three fibronectin type III repeats. The ligand angiopoietin-1 binds to this receptor and mediates a signaling pathway that functions in embryonic vascular development. Mutations in this gene are associated with inherited venous malformations of the skin and mucous membranes. Alternative splicing results in multiple transcript variants. Additional alternatively spliced transcript variants of this gene have been described, but their full-length nature is not known. [provided by RefSeq, Feb 2014].
Isoforms & Proteins
4 transcripts · UniProt mapping is sequence-verified (AA-safe)
Each Ensembl transcript (ENST) this gene is mutated on, with its matched UniProt accession.
The mapping is sequence-verified: the UniProt sequence is identical to the transcript translation, so amino-acid positions line up exactly. A * marks an unreviewed (TrEMBL) entry.
Counts are mutations and unique mutant peptides on each transcript.
| Transcript | UniProt | Mutations | Peptides |
|---|---|---|---|
| ENST00000380036 | Q02763 | 710 | 495 |
| ENST00000406359 | Q02763-2 | 616 | 452 |
| ENST00000519097 | Q02763-3 | 561 | 419 |
| ENST00000615002 | A0A087WWI7* | 252 | 176 |
Gene Properties
Recurrent Mutations
All 495 amino-acid changes on canonical ENST00000380036 · needle height = samples · drag the mini-map to zoom
A lollipop / needle plot – the standard way to show recurrent mutations along a protein (as used by cBioPortal and MutationMapper).
X-axis = amino-acid position in the protein.
Needle height & head size = how often that exact amino-acid change was observed (its recurrence). Tall/large heads are mutational hotspots.
The most recurrent changes are labelled; hover any needle for the change, position and counts.
Mutation frequency across cancer types
% of samples with a missense/complex mutation in TEK · cell line vs tissue
For each cancer type, the fraction of samples that carry at least one missense/complex mutation anywhere in TEK – counted as distinct samples (a sample counts once no matter how many mutations it has).
Split into cell line and tissue; each cell shows mutated / total and the percentage. Cohorts with <20 samples are omitted. Ordered by combined frequency.
| Cancer type | Cell lines | Tissue samples |
|---|---|---|
| Melanoma | 17/210 8% | 107/1899 6% |
| Endometrial Carcinoma | 7/42 17% | 29/612 5% |
| T-Lymphoblastic Leukemia | 2/40 5% | 0/0 0% |
| Chordoma | 0/7 0% | 1/13 8% |
| T-Cell Non-Hodgkins Lymphoma | 1/26 4% | 0/0 0% |
| Hodgkins Lymphoma | 4/16 25% | 0/122 0% |
| Bladder Carcinoma | 0/58 0% | 26/956 3% |
| Thymic Epithelial Tumor | 0/0 0% | 1/39 3% |
| Colorectal Carcinoma | 19/143 13% | 67/3239 2% |
| Non-Small Cell Lung Carcinoma | 15/304 5% | 24/1390 2% |
| Gastrointestinal Stromal Tumour | 0/0 0% | 3/133 2% |
| Gastric Carcinoma | 0/74 0% | 39/1809 2% |
| Germ Cell Tumour | 2/25 8% | 2/169 1% |
| Other Solid Cancers | 5/94 5% | 25/1515 2% |
| Plasma Cell Myeloma | 2/44 5% | 4/305 1% |
| Squamous Cell Lung Carcinoma | 0/57 0% | 14/810 2% |
| Cervical Carcinoma | 0/35 0% | 7/422 2% |
| Ovarian Carcinoma | 8/109 7% | 8/998 1% |
| Neuroendocrine Tumour | 8/154 5% | 2/577 0% |
| Hepatocellular Carcinoma | 0/46 0% | 29/2210 1% |
| Non-Cancerous | 1/104 1% | 11/830 1% |
| Other Sarcomas | 3/69 4% | 5/699 1% |
| Adrenocortical Carcinoma | 0/3 0% | 1/112 1% |
| Thyroid Gland Carcinoma | 2/45 4% | 12/1592 1% |
| Small Cell Lung Carcinoma | 0/9 0% | 6/752 1% |
| Glioma | 0/52 0% | 17/2127 1% |
| Breast Carcinoma | 3/144 2% | 22/3264 1% |
| Head and Neck Carcinoma | 0/85 0% | 12/1574 1% |
| Biliary Tract Carcinoma | 1/54 2% | 6/950 1% |
| Ewings Sarcoma | 0/63 0% | 2/262 1% |
Mutation Distribution
Where TEK is mutated · all tissues, split by cell line vs tissue
How many mutations in TEK were found in each tissue, across the whole database.
Each bar is a tissue (cell-line and tissue names are merged to the standard tissue), split into cell line and tissue (patient tumour) contributions.
This shows the cancer-context where this gene is recurrently altered.
GTEx Expression
Median TPM across 54 healthy tissues
Median gene expression (TPM) in normal, non-cancer human tissues from the GTEx project.
Useful for judging tumour specificity – a strong neoantigen target ideally comes from a gene with low expression in healthy tissues.
Scroll or drag the mini-axis below the chart to browse all tissues.
Mutations
All 2,139 mutations in TEK
Every mutation record for this gene, across all samples and sources.
The Sample column links to the cell line (cell-line samples) or the tissue type (tissue samples).
Use the Type / Source filters, the search box, and column sorting to explore; each CAN-IMMUNE ID opens the full mutation & peptide view.
| ID | Sample | Transcript | AA Change | CDS | Type | Source | Mutant Peptide | Wild-type Peptide |
|---|