Stats by Source
Total, split by cell line (COSMIC CL / DepMap / PubMed) vs tissue (COSMIC primary tissue)
Total = all mutations for this gene across every source.
Cell line = COSMIC Cell Lines Project + DepMap + PubMed.
Tissue = COSMIC primary-tissue (patient tumour) samples.
Total can exceed cell line + tissue: COSMIC tissue-derived models sit only in global, and a peptide can be shared across both.
| Total | Cell line | Tissue | |
|---|---|---|---|
| Mutations | 1,068 | 185 | 873 |
| Samples | 773 | 154 | 613 |
| Peptides | 556 | 102 | 471 |
Function
TIE1 · Tyrosine kinase with immunoglobulin like and EGF like domains 1
This gene encodes a member of the tyrosine protein kinase family. The encoded protein plays a critical role in angiogenesis and blood vessel stability by inhibiting angiopoietin 1 signaling through the endothelial receptor tyrosine kinase Tie2. Ectodomain cleavage of the encoded protein relieves inhibition of Tie2 and is mediated by multiple factors including vascular endothelial growth factor. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Nov 2011].
Isoforms & Proteins
2 transcripts · UniProt mapping is sequence-verified (AA-safe)
Each Ensembl transcript (ENST) this gene is mutated on, with its matched UniProt accession.
The mapping is sequence-verified: the UniProt sequence is identical to the transcript translation, so amino-acid positions line up exactly. A * marks an unreviewed (TrEMBL) entry.
Counts are mutations and unique mutant peptides on each transcript.
Gene Properties
Recurrent Mutations
All 552 amino-acid changes on canonical ENST00000372476 · needle height = samples · drag the mini-map to zoom
A lollipop / needle plot – the standard way to show recurrent mutations along a protein (as used by cBioPortal and MutationMapper).
X-axis = amino-acid position in the protein.
Needle height & head size = how often that exact amino-acid change was observed (its recurrence). Tall/large heads are mutational hotspots.
The most recurrent changes are labelled; hover any needle for the change, position and counts.
Mutation frequency across cancer types
% of samples with a missense/complex mutation in TIE1 · cell line vs tissue
For each cancer type, the fraction of samples that carry at least one missense/complex mutation anywhere in TIE1 – counted as distinct samples (a sample counts once no matter how many mutations it has).
Split into cell line and tissue; each cell shows mutated / total and the percentage. Cohorts with <20 samples are omitted. Ordered by combined frequency.
| Cancer type | Cell lines | Tissue samples |
|---|---|---|
| T-Lymphoblastic Leukemia | 7/40 18% | 0/0 0% |
| Chordoma | 0/7 0% | 2/13 15% |
| Chronic Myelogenous Leukemia | 2/25 8% | 0/0 0% |
| Melanoma | 12/210 6% | 100/1899 5% |
| Endometrial Carcinoma | 8/42 19% | 26/612 4% |
| Squamous Cell Lung Carcinoma | 8/57 14% | 27/810 3% |
| T-Cell Non-Hodgkins Lymphoma | 1/26 4% | 0/0 0% |
| Acute Monocytic Leukemia | 0/1 0% | 1/25 4% |
| Oral Cavity Carcinoma | 2/54 4% | 0/0 0% |
| Other Solid Cancers | 2/94 2% | 54/1515 4% |
| Colorectal Carcinoma | 20/143 14% | 85/3239 3% |
| Glioblastoma | 3/98 3% | 0/0 0% |
| Unknown | 1/10 10% | 0/29 0% |
| Gastric Carcinoma | 4/74 5% | 43/1809 2% |
| Ewings Sarcoma | 5/63 8% | 3/262 1% |
| Osteosarcoma | 1/45 2% | 4/166 2% |
| Bladder Carcinoma | 3/58 5% | 17/956 2% |
| Neuroendocrine Tumour | 7/154 5% | 6/577 1% |
| Non-Small Cell Lung Carcinoma | 10/304 3% | 20/1390 1% |
| Cervical Carcinoma | 0/35 0% | 8/422 2% |
| Head and Neck Carcinoma | 6/85 7% | 20/1574 1% |
| Gastrointestinal Stromal Tumour | 0/0 0% | 2/133 2% |
| Small Cell Lung Carcinoma | 0/9 0% | 11/752 1% |
| Hodgkins Lymphoma | 0/16 0% | 2/122 2% |
| Glioma | 5/52 10% | 25/2127 1% |
| Thyroid Gland Carcinoma | 0/45 0% | 22/1592 1% |
| Burkitts Lymphoma | 3/32 9% | 0/196 0% |
| Other Sarcomas | 4/69 6% | 6/699 1% |
| Chondrosarcoma | 0/14 0% | 1/75 1% |
| Germ Cell Tumour | 0/25 0% | 2/169 1% |
Mutation Distribution
Where TIE1 is mutated · all tissues, split by cell line vs tissue
How many mutations in TIE1 were found in each tissue, across the whole database.
Each bar is a tissue (cell-line and tissue names are merged to the standard tissue), split into cell line and tissue (patient tumour) contributions.
This shows the cancer-context where this gene is recurrently altered.
GTEx Expression
Median TPM across 54 healthy tissues
Median gene expression (TPM) in normal, non-cancer human tissues from the GTEx project.
Useful for judging tumour specificity – a strong neoantigen target ideally comes from a gene with low expression in healthy tissues.
Scroll or drag the mini-axis below the chart to browse all tissues.
Mutations
All 1,068 mutations in TIE1
Every mutation record for this gene, across all samples and sources.
The Sample column links to the cell line (cell-line samples) or the tissue type (tissue samples).
Use the Type / Source filters, the search box, and column sorting to explore; each CAN-IMMUNE ID opens the full mutation & peptide view.
| ID | Sample | Transcript | AA Change | CDS | Type | Source | Mutant Peptide | Wild-type Peptide |
|---|