Stats by Source
Total, split by cell line (COSMIC CL / DepMap / PubMed) vs tissue (COSMIC primary tissue)
Total = all mutations for this gene across every source.
Cell line = COSMIC Cell Lines Project + DepMap + PubMed.
Tissue = COSMIC primary-tissue (patient tumour) samples.
Total can exceed cell line + tissue: COSMIC tissue-derived models sit only in global, and a peptide can be shared across both.
| Total | Cell line | Tissue | |
|---|---|---|---|
| Mutations | 1,092 | 130 | 943 |
| Samples | 307 | 64 | 237 |
| Peptides | 259 | 42 | 218 |
Function
TLK1 · Tousled like kinase 1
The protein encoded by this gene is a serine/threonine kinase that may be involved in the regulation of chromatin assembly. The encoded protein is only active when it is phosphorylated, and this phosphorylation is cell cycle-dependent, with the maximal activity of this protein coming during S phase. The catalytic activity of this protein is diminished by DNA damage and by blockage of DNA replication. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2011].
Isoforms & Proteins
4 transcripts · UniProt mapping is sequence-verified (AA-safe)
Each Ensembl transcript (ENST) this gene is mutated on, with its matched UniProt accession.
The mapping is sequence-verified: the UniProt sequence is identical to the transcript translation, so amino-acid positions line up exactly. A * marks an unreviewed (TrEMBL) entry.
Counts are mutations and unique mutant peptides on each transcript.
Gene Properties
Recurrent Mutations
All 237 amino-acid changes on canonical ENST00000431350 · needle height = samples · drag the mini-map to zoom
A lollipop / needle plot – the standard way to show recurrent mutations along a protein (as used by cBioPortal and MutationMapper).
X-axis = amino-acid position in the protein.
Needle height & head size = how often that exact amino-acid change was observed (its recurrence). Tall/large heads are mutational hotspots.
The most recurrent changes are labelled; hover any needle for the change, position and counts.
Mutation frequency across cancer types
% of samples with a missense/complex mutation in TLK1 · cell line vs tissue
For each cancer type, the fraction of samples that carry at least one missense/complex mutation anywhere in TLK1 – counted as distinct samples (a sample counts once no matter how many mutations it has).
Split into cell line and tissue; each cell shows mutated / total and the percentage. Cohorts with <20 samples are omitted. Ordered by combined frequency.
| Cancer type | Cell lines | Tissue samples |
|---|---|---|
| T-Lymphoblastic Leukemia | 6/40 15% | 0/0 0% |
| Endometrial Carcinoma | 7/42 17% | 26/612 4% |
| Melanoma | 7/210 3% | 21/1899 1% |
| Burkitts Lymphoma | 2/32 6% | 1/196 1% |
| Colorectal Carcinoma | 10/143 7% | 27/3239 1% |
| Glioblastoma | 1/98 1% | 0/0 0% |
| Other Solid Cancers | 0/94 0% | 16/1515 1% |
| Neuroendocrine Tumour | 3/154 2% | 4/577 1% |
| Small Cell Lung Carcinoma | 0/9 0% | 7/752 1% |
| Bladder Carcinoma | 1/58 2% | 8/956 1% |
| Other Sarcomas | 2/69 3% | 4/699 1% |
| Head and Neck Carcinoma | 2/85 2% | 11/1574 1% |
| Non-Small Cell Lung Carcinoma | 5/304 2% | 7/1390 0% |
| Thyroid Gland Carcinoma | 3/45 7% | 8/1592 0% |
| Cervical Carcinoma | 0/35 0% | 3/422 1% |
| Esophageal Squamous Cell Carcinoma | 0/51 0% | 17/2550 1% |
| Gastric Carcinoma | 2/74 3% | 10/1809 1% |
| Ovarian Carcinoma | 2/109 2% | 5/998 0% |
| Esophageal Carcinoma | 2/23 9% | 3/769 0% |
| Squamous Cell Lung Carcinoma | 0/57 0% | 5/810 1% |
| Plasma Cell Myeloma | 1/44 2% | 1/305 0% |
| Germ Cell Tumour | 0/25 0% | 1/169 1% |
| Biliary Tract Carcinoma | 0/54 0% | 5/950 1% |
| Hepatocellular Carcinoma | 0/46 0% | 10/2210 0% |
| Breast Carcinoma | 2/144 1% | 12/3264 0% |
| Neuroblastoma | 2/87 2% | 3/1331 0% |
| Prostate Carcinoma | 0/13 0% | 6/2105 0% |
| Glioma | 0/52 0% | 6/2127 0% |
| Pancreatic Carcinoma | 0/89 0% | 4/1611 0% |
| B-Cell Non-Hodgkins Lymphoma | 2/88 2% | 4/2534 0% |
Mutation Distribution
Where TLK1 is mutated · all tissues, split by cell line vs tissue
How many mutations in TLK1 were found in each tissue, across the whole database.
Each bar is a tissue (cell-line and tissue names are merged to the standard tissue), split into cell line and tissue (patient tumour) contributions.
This shows the cancer-context where this gene is recurrently altered.
GTEx Expression
Median TPM across 54 healthy tissues
Median gene expression (TPM) in normal, non-cancer human tissues from the GTEx project.
Useful for judging tumour specificity – a strong neoantigen target ideally comes from a gene with low expression in healthy tissues.
Scroll or drag the mini-axis below the chart to browse all tissues.
Mutations
All 1,092 mutations in TLK1
Every mutation record for this gene, across all samples and sources.
The Sample column links to the cell line (cell-line samples) or the tissue type (tissue samples).
Use the Type / Source filters, the search box, and column sorting to explore; each CAN-IMMUNE ID opens the full mutation & peptide view.
| ID | Sample | Transcript | AA Change | CDS | Type | Source | Mutant Peptide | Wild-type Peptide |
|---|