Stats by Source
Total, split by cell line (COSMIC CL / DepMap / PubMed) vs tissue (COSMIC primary tissue)
Total = all mutations for this gene across every source.
Cell line = COSMIC Cell Lines Project + DepMap + PubMed.
Tissue = COSMIC primary-tissue (patient tumour) samples.
Total can exceed cell line + tissue: COSMIC tissue-derived models sit only in global, and a peptide can be shared across both.
| Total | Cell line | Tissue | |
|---|---|---|---|
| Mutations | 1,091 | 229 | 837 |
| Samples | 949 | 192 | 740 |
| Peptides | 826 | 150 | 681 |
Function
TLN1 · Talin 1
This gene encodes a cytoskeletal protein that is concentrated in areas of cell-substratum and cell-cell contacts. The encoded protein plays a significant role in the assembly of actin filaments and in spreading and migration of various cell types, including fibroblasts and osteoclasts. It codistributes with integrins in the cell surface membrane in order to assist in the attachment of adherent cells to extracellular matrices and of lymphocytes to other cells. The N-terminus of this protein contains elements for localization to cell-extracellular matrix junctions. The C-terminus contains binding sites for proteins such as beta-1-integrin, actin, and vinculin. [provided by RefSeq, Feb 2009].
Isoforms & Proteins
1 transcript · UniProt mapping is sequence-verified (AA-safe)
Each Ensembl transcript (ENST) this gene is mutated on, with its matched UniProt accession.
The mapping is sequence-verified: the UniProt sequence is identical to the transcript translation, so amino-acid positions line up exactly. A * marks an unreviewed (TrEMBL) entry.
Counts are mutations and unique mutant peptides on each transcript.
| Transcript | UniProt | Mutations | Peptides |
|---|---|---|---|
| ENST00000314888 | Q9Y490 | 1,091 | 826 |
Gene Properties
Recurrent Mutations
All 826 amino-acid changes on canonical ENST00000314888 · needle height = samples · drag the mini-map to zoom
A lollipop / needle plot – the standard way to show recurrent mutations along a protein (as used by cBioPortal and MutationMapper).
X-axis = amino-acid position in the protein.
Needle height & head size = how often that exact amino-acid change was observed (its recurrence). Tall/large heads are mutational hotspots.
The most recurrent changes are labelled; hover any needle for the change, position and counts.
Mutation frequency across cancer types
% of samples with a missense/complex mutation in TLN1 · cell line vs tissue
For each cancer type, the fraction of samples that carry at least one missense/complex mutation anywhere in TLN1 – counted as distinct samples (a sample counts once no matter how many mutations it has).
Split into cell line and tissue; each cell shows mutated / total and the percentage. Cohorts with <20 samples are omitted. Ordered by combined frequency.
| Cancer type | Cell lines | Tissue samples |
|---|---|---|
| T-Lymphoblastic Leukemia | 9/40 22% | 0/0 0% |
| Chronic Myelogenous Leukemia | 5/25 20% | 0/0 0% |
| Acute Monocytic Leukemia | 0/1 0% | 2/25 8% |
| Endometrial Carcinoma | 13/42 31% | 37/612 6% |
| Melanoma | 8/210 4% | 81/1899 4% |
| Gastrointestinal Stromal Tumour | 0/0 0% | 5/133 4% |
| Gastric Carcinoma | 7/74 9% | 63/1809 3% |
| Oral Cavity Carcinoma | 2/54 4% | 0/0 0% |
| Colorectal Carcinoma | 31/143 22% | 92/3239 3% |
| Hodgkins Lymphoma | 2/16 12% | 3/122 2% |
| Other Solid Cancers | 3/94 3% | 54/1515 4% |
| Cervical Carcinoma | 4/35 11% | 11/422 3% |
| Non-Small Cell Lung Carcinoma | 20/304 7% | 31/1390 2% |
| Head and Neck Carcinoma | 8/85 9% | 42/1574 3% |
| Unknown | 1/10 10% | 0/29 0% |
| Rhabdomyosarcoma | 5/33 15% | 0/171 0% |
| Other Sarcomas | 1/69 1% | 17/699 2% |
| Squamous Cell Lung Carcinoma | 1/57 2% | 19/810 2% |
| Chondrosarcoma | 2/14 14% | 0/75 0% |
| Bladder Carcinoma | 1/58 2% | 21/956 2% |
| Germ Cell Tumour | 1/25 4% | 3/169 2% |
| Plasma Cell Myeloma | 2/44 5% | 4/305 1% |
| Hepatocellular Carcinoma | 3/46 7% | 35/2210 2% |
| Neuroendocrine Tumour | 10/154 6% | 2/577 0% |
| Esophageal Squamous Cell Carcinoma | 1/51 2% | 37/2550 1% |
| Ovarian Carcinoma | 7/109 6% | 9/998 1% |
| Kidney Carcinoma | 4/85 5% | 24/1862 1% |
| Osteosarcoma | 2/45 4% | 1/166 1% |
| Pheochromocytoma and Paraganglioma | 0/0 0% | 1/71 1% |
| Glioma | 0/52 0% | 27/2127 1% |
Mutation Distribution
Where TLN1 is mutated · all tissues, split by cell line vs tissue
How many mutations in TLN1 were found in each tissue, across the whole database.
Each bar is a tissue (cell-line and tissue names are merged to the standard tissue), split into cell line and tissue (patient tumour) contributions.
This shows the cancer-context where this gene is recurrently altered.
GTEx Expression
Median TPM across 54 healthy tissues
Median gene expression (TPM) in normal, non-cancer human tissues from the GTEx project.
Useful for judging tumour specificity – a strong neoantigen target ideally comes from a gene with low expression in healthy tissues.
Scroll or drag the mini-axis below the chart to browse all tissues.
Mutations
All 1,091 mutations in TLN1
Every mutation record for this gene, across all samples and sources.
The Sample column links to the cell line (cell-line samples) or the tissue type (tissue samples).
Use the Type / Source filters, the search box, and column sorting to explore; each CAN-IMMUNE ID opens the full mutation & peptide view.
| ID | Sample | Transcript | AA Change | CDS | Type | Source | Mutant Peptide | Wild-type Peptide |
|---|