Stats by Source
Total, split by cell line (COSMIC CL / DepMap / PubMed) vs tissue (COSMIC primary tissue)
Total = all mutations for this gene across every source.
Cell line = COSMIC Cell Lines Project + DepMap + PubMed.
Tissue = COSMIC primary-tissue (patient tumour) samples.
Total can exceed cell line + tissue: COSMIC tissue-derived models sit only in global, and a peptide can be shared across both.
| Total | Cell line | Tissue | |
|---|---|---|---|
| Mutations | 1,133 | 144 | 978 |
| Samples | 376 | 66 | 305 |
| Peptides | 287 | 45 | 250 |
Function
TLR2 · Toll like receptor 2
The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. This protein is a cell-surface protein that can form heterodimers with other TLR family members to recognize conserved molecules derived from microorganisms known as pathogen-associated molecular patterns (PAMPs). Activation of TLRs by PAMPs leads to an up-regulation of signaling pathways to modulate the host's inflammatory response. This gene is also thought to promote apoptosis in response to bacterial lipoproteins. This gene has been implicated in the pathogenesis of several autoimmune diseases. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2016].
Isoforms & Proteins
3 transcripts · UniProt mapping is sequence-verified (AA-safe)
Each Ensembl transcript (ENST) this gene is mutated on, with its matched UniProt accession.
The mapping is sequence-verified: the UniProt sequence is identical to the transcript translation, so amino-acid positions line up exactly. A * marks an unreviewed (TrEMBL) entry.
Counts are mutations and unique mutant peptides on each transcript.
Gene Properties
Recurrent Mutations
All 287 amino-acid changes on canonical ENST00000642700 · needle height = samples · drag the mini-map to zoom
A lollipop / needle plot – the standard way to show recurrent mutations along a protein (as used by cBioPortal and MutationMapper).
X-axis = amino-acid position in the protein.
Needle height & head size = how often that exact amino-acid change was observed (its recurrence). Tall/large heads are mutational hotspots.
The most recurrent changes are labelled; hover any needle for the change, position and counts.
Mutation frequency across cancer types
% of samples with a missense/complex mutation in TLR2 · cell line vs tissue
For each cancer type, the fraction of samples that carry at least one missense/complex mutation anywhere in TLR2 – counted as distinct samples (a sample counts once no matter how many mutations it has).
Split into cell line and tissue; each cell shows mutated / total and the percentage. Cohorts with <20 samples are omitted. Ordered by combined frequency.
| Cancer type | Cell lines | Tissue samples |
|---|---|---|
| Chordoma | 0/7 0% | 1/13 8% |
| Endometrial Carcinoma | 4/42 10% | 18/612 3% |
| Melanoma | 7/210 3% | 51/1899 3% |
| Hodgkins Lymphoma | 2/16 12% | 1/122 1% |
| Cervical Carcinoma | 0/35 0% | 8/422 2% |
| Colorectal Carcinoma | 18/143 13% | 36/3239 1% |
| Non-Small Cell Lung Carcinoma | 5/304 2% | 18/1390 1% |
| Other Solid Cancers | 0/94 0% | 20/1515 1% |
| Ewings Sarcoma | 0/63 0% | 4/262 2% |
| Gastric Carcinoma | 2/74 3% | 20/1809 1% |
| Esophageal Carcinoma | 1/23 4% | 8/769 1% |
| Acute Myeloid Leukemia | 1/90 1% | 0/0 0% |
| Germ Cell Tumour | 0/25 0% | 2/169 1% |
| Rhabdomyosarcoma | 0/33 0% | 2/171 1% |
| Squamous Cell Lung Carcinoma | 3/57 5% | 5/810 1% |
| Non-Cancerous | 2/104 2% | 6/830 1% |
| Biliary Tract Carcinoma | 0/54 0% | 8/950 1% |
| Gastrointestinal Stromal Tumour | 0/0 0% | 1/133 1% |
| Other Sarcomas | 1/69 1% | 4/699 1% |
| B-Cell Non-Hodgkins Lymphoma | 2/88 2% | 14/2534 1% |
| Glioma | 1/52 2% | 12/2127 1% |
| Bladder Carcinoma | 1/58 2% | 5/956 1% |
| Esophageal Squamous Cell Carcinoma | 1/51 2% | 14/2550 1% |
| Plasma Cell Myeloma | 0/44 0% | 2/305 1% |
| Kidney Carcinoma | 2/85 2% | 7/1862 0% |
| Mesothelioma | 1/62 2% | 0/165 0% |
| Neuroendocrine Tumour | 2/154 1% | 1/577 0% |
| Prostate Carcinoma | 0/13 0% | 7/2105 0% |
| Hepatocellular Carcinoma | 2/46 4% | 5/2210 0% |
| Head and Neck Carcinoma | 0/85 0% | 5/1574 0% |
Mutation Distribution
Where TLR2 is mutated · all tissues, split by cell line vs tissue
How many mutations in TLR2 were found in each tissue, across the whole database.
Each bar is a tissue (cell-line and tissue names are merged to the standard tissue), split into cell line and tissue (patient tumour) contributions.
This shows the cancer-context where this gene is recurrently altered.
GTEx Expression
Median TPM across 54 healthy tissues
Median gene expression (TPM) in normal, non-cancer human tissues from the GTEx project.
Useful for judging tumour specificity – a strong neoantigen target ideally comes from a gene with low expression in healthy tissues.
Scroll or drag the mini-axis below the chart to browse all tissues.
Mutations
All 1,133 mutations in TLR2
Every mutation record for this gene, across all samples and sources.
The Sample column links to the cell line (cell-line samples) or the tissue type (tissue samples).
Use the Type / Source filters, the search box, and column sorting to explore; each CAN-IMMUNE ID opens the full mutation & peptide view.
| ID | Sample | Transcript | AA Change | CDS | Type | Source | Mutant Peptide | Wild-type Peptide |
|---|