Stats by Source
Total, split by cell line (COSMIC CL / DepMap / PubMed) vs tissue (COSMIC primary tissue)
Total = all mutations for this gene across every source.
Cell line = COSMIC Cell Lines Project + DepMap + PubMed.
Tissue = COSMIC primary-tissue (patient tumour) samples.
Total can exceed cell line + tissue: COSMIC tissue-derived models sit only in global, and a peptide can be shared across both.
| Total | Cell line | Tissue | |
|---|---|---|---|
| Mutations | 943 | 162 | 764 |
| Samples | 459 | 98 | 353 |
| Peptides | 345 | 59 | 287 |
Function
TLR5 · Toll like receptor 5
This gene encodes a member of the toll-like receptor (TLR) family, which plays a fundamental role in pathogen recognition and activation of innate immune responses. These receptors recognize distinct pathogen-associated molecular patterns that are expressed on infectious agents. The protein encoded by this gene recognizes bacterial flagellin, the principal component of bacterial flagella and a virulence factor. The activation of this receptor mobilizes the nuclear factor NF-kappaB, which in turn activates a host of inflammatory-related target genes. Mutations in this gene have been associated with both resistance and susceptibility to systemic lupus erythematosus, and susceptibility to Legionnaire disease.[provided by RefSeq, Dec 2009].
Isoforms & Proteins
3 transcripts · UniProt mapping is sequence-verified (AA-safe)
Each Ensembl transcript (ENST) this gene is mutated on, with its matched UniProt accession.
The mapping is sequence-verified: the UniProt sequence is identical to the transcript translation, so amino-acid positions line up exactly. A * marks an unreviewed (TrEMBL) entry.
Counts are mutations and unique mutant peptides on each transcript.
Gene Properties
Recurrent Mutations
All 344 amino-acid changes on canonical ENST00000642603 · needle height = samples · drag the mini-map to zoom
A lollipop / needle plot – the standard way to show recurrent mutations along a protein (as used by cBioPortal and MutationMapper).
X-axis = amino-acid position in the protein.
Needle height & head size = how often that exact amino-acid change was observed (its recurrence). Tall/large heads are mutational hotspots.
The most recurrent changes are labelled; hover any needle for the change, position and counts.
Mutation frequency across cancer types
% of samples with a missense/complex mutation in TLR5 · cell line vs tissue
For each cancer type, the fraction of samples that carry at least one missense/complex mutation anywhere in TLR5 – counted as distinct samples (a sample counts once no matter how many mutations it has).
Split into cell line and tissue; each cell shows mutated / total and the percentage. Cohorts with <20 samples are omitted. Ordered by combined frequency.
| Cancer type | Cell lines | Tissue samples |
|---|---|---|
| T-Lymphoblastic Leukemia | 10/40 25% | 0/0 0% |
| Endometrial Carcinoma | 4/42 10% | 29/612 5% |
| Melanoma | 10/210 5% | 76/1899 4% |
| T-Cell Non-Hodgkins Lymphoma | 1/26 4% | 0/0 0% |
| Oral Cavity Carcinoma | 1/54 2% | 0/0 0% |
| Colorectal Carcinoma | 8/143 6% | 52/3239 2% |
| Non-Small Cell Lung Carcinoma | 12/304 4% | 17/1390 1% |
| Squamous Cell Lung Carcinoma | 6/57 11% | 8/810 1% |
| Gastrointestinal Stromal Tumour | 0/0 0% | 2/133 2% |
| Gastric Carcinoma | 1/74 1% | 26/1809 1% |
| Other Sarcomas | 3/69 4% | 8/699 1% |
| Bladder Carcinoma | 0/58 0% | 14/956 1% |
| Other Solid Cancers | 4/94 4% | 17/1515 1% |
| Plasma Cell Myeloma | 1/44 2% | 3/305 1% |
| Cervical Carcinoma | 2/35 6% | 3/422 1% |
| Small Cell Lung Carcinoma | 0/9 0% | 8/752 1% |
| Germ Cell Tumour | 0/25 0% | 2/169 1% |
| Neuroendocrine Tumour | 6/154 4% | 1/577 0% |
| Ovarian Carcinoma | 6/109 6% | 4/998 0% |
| Esophageal Carcinoma | 0/23 0% | 7/769 1% |
| Burkitts Lymphoma | 2/32 6% | 0/196 0% |
| Non-Cancerous | 0/104 0% | 7/830 1% |
| Ewings Sarcoma | 1/63 2% | 1/262 0% |
| Hepatocellular Carcinoma | 3/46 7% | 9/2210 0% |
| Biliary Tract Carcinoma | 2/54 4% | 3/950 0% |
| Breast Carcinoma | 3/144 2% | 14/3264 0% |
| Rhabdomyosarcoma | 0/33 0% | 1/171 1% |
| Head and Neck Carcinoma | 1/85 1% | 7/1574 0% |
| Kidney Carcinoma | 4/85 5% | 5/1862 0% |
| Meningioma | 0/3 0% | 1/252 0% |
Mutation Distribution
Where TLR5 is mutated · all tissues, split by cell line vs tissue
How many mutations in TLR5 were found in each tissue, across the whole database.
Each bar is a tissue (cell-line and tissue names are merged to the standard tissue), split into cell line and tissue (patient tumour) contributions.
This shows the cancer-context where this gene is recurrently altered.
GTEx Expression
Median TPM across 54 healthy tissues
Median gene expression (TPM) in normal, non-cancer human tissues from the GTEx project.
Useful for judging tumour specificity – a strong neoantigen target ideally comes from a gene with low expression in healthy tissues.
Scroll or drag the mini-axis below the chart to browse all tissues.
Mutations
All 943 mutations in TLR5
Every mutation record for this gene, across all samples and sources.
The Sample column links to the cell line (cell-line samples) or the tissue type (tissue samples).
Use the Type / Source filters, the search box, and column sorting to explore; each CAN-IMMUNE ID opens the full mutation & peptide view.
| ID | Sample | Transcript | AA Change | CDS | Type | Source | Mutant Peptide | Wild-type Peptide |
|---|