Stats by Source
Total, split by cell line (COSMIC CL / DepMap / PubMed) vs tissue (COSMIC primary tissue)
Total = all mutations for this gene across every source.
Cell line = COSMIC Cell Lines Project + DepMap + PubMed.
Tissue = COSMIC primary-tissue (patient tumour) samples.
Total can exceed cell line + tissue: COSMIC tissue-derived models sit only in global, and a peptide can be shared across both.
| Total | Cell line | Tissue | |
|---|---|---|---|
| Mutations | 652 | 98 | 550 |
| Samples | 290 | 52 | 235 |
| Peptides | 220 | 40 | 185 |
Function
TMEFF2 · Transmembrane protein with EGF like and two follistatin like domains 2
This gene encodes a member of the tomoregulin family of transmembrane proteins. This protein has been shown to function as both an oncogene and a tumor suppressor depending on the cellular context and may regulate prostate cancer cell invasion. Multiple soluble forms of this protein have been identified that arise from both an alternative splice variant and ectodomain shedding. Additionally, this gene has been found to be hypermethylated in multiple cancer types. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2015].
Isoforms & Proteins
3 transcripts · UniProt mapping is sequence-verified (AA-safe)
Each Ensembl transcript (ENST) this gene is mutated on, with its matched UniProt accession.
The mapping is sequence-verified: the UniProt sequence is identical to the transcript translation, so amino-acid positions line up exactly. A * marks an unreviewed (TrEMBL) entry.
Counts are mutations and unique mutant peptides on each transcript.
Gene Properties
Recurrent Mutations
All 195 amino-acid changes on canonical ENST00000272771 · needle height = samples · drag the mini-map to zoom
A lollipop / needle plot – the standard way to show recurrent mutations along a protein (as used by cBioPortal and MutationMapper).
X-axis = amino-acid position in the protein.
Needle height & head size = how often that exact amino-acid change was observed (its recurrence). Tall/large heads are mutational hotspots.
The most recurrent changes are labelled; hover any needle for the change, position and counts.
Mutation frequency across cancer types
% of samples with a missense/complex mutation in TMEFF2 · cell line vs tissue
For each cancer type, the fraction of samples that carry at least one missense/complex mutation anywhere in TMEFF2 – counted as distinct samples (a sample counts once no matter how many mutations it has).
Split into cell line and tissue; each cell shows mutated / total and the percentage. Cohorts with <20 samples are omitted. Ordered by combined frequency.
| Cancer type | Cell lines | Tissue samples |
|---|---|---|
| T-Lymphoblastic Leukemia | 2/40 5% | 0/0 0% |
| Melanoma | 6/210 3% | 49/1899 3% |
| Endometrial Carcinoma | 3/42 7% | 14/612 2% |
| Non-Small Cell Lung Carcinoma | 11/304 4% | 13/1390 1% |
| Other Solid Cancers | 3/94 3% | 18/1515 1% |
| Bladder Carcinoma | 0/58 0% | 11/956 1% |
| Germ Cell Tumour | 2/25 8% | 0/169 0% |
| Esophageal Carcinoma | 0/23 0% | 8/769 1% |
| Gastric Carcinoma | 2/74 3% | 16/1809 1% |
| Colorectal Carcinoma | 4/143 3% | 25/3239 1% |
| Hepatocellular Carcinoma | 0/46 0% | 13/2210 1% |
| Squamous Cell Lung Carcinoma | 3/57 5% | 2/810 0% |
| Small Cell Lung Carcinoma | 0/9 0% | 4/752 1% |
| Esophageal Squamous Cell Carcinoma | 1/51 2% | 12/2550 0% |
| Rhabdomyosarcoma | 1/33 3% | 0/171 0% |
| Mesothelioma | 1/62 2% | 0/165 0% |
| Cervical Carcinoma | 0/35 0% | 2/422 0% |
| Head and Neck Carcinoma | 0/85 0% | 7/1574 0% |
| Glioma | 0/52 0% | 9/2127 0% |
| Meningioma | 0/3 0% | 1/252 0% |
| Breast Carcinoma | 7/144 5% | 6/3264 0% |
| Ovarian Carcinoma | 1/109 1% | 3/998 0% |
| Plasma Cell Myeloma | 0/44 0% | 1/305 0% |
| Pancreatic Carcinoma | 0/89 0% | 5/1611 0% |
| Neuroendocrine Tumour | 2/154 1% | 0/577 0% |
| B-Cell Non-Hodgkins Lymphoma | 2/88 2% | 4/2534 0% |
| Kidney Carcinoma | 1/85 1% | 3/1862 0% |
| Non-Cancerous | 0/104 0% | 2/830 0% |
| Biliary Tract Carcinoma | 0/54 0% | 2/950 0% |
| B-Lymphoblastic Leukemia | 0/55 0% | 4/2640 0% |
Mutation Distribution
Where TMEFF2 is mutated · all tissues, split by cell line vs tissue
How many mutations in TMEFF2 were found in each tissue, across the whole database.
Each bar is a tissue (cell-line and tissue names are merged to the standard tissue), split into cell line and tissue (patient tumour) contributions.
This shows the cancer-context where this gene is recurrently altered.
GTEx Expression
Median TPM across 53 healthy tissues
Median gene expression (TPM) in normal, non-cancer human tissues from the GTEx project.
Useful for judging tumour specificity – a strong neoantigen target ideally comes from a gene with low expression in healthy tissues.
Scroll or drag the mini-axis below the chart to browse all tissues.
Mutations
All 652 mutations in TMEFF2
Every mutation record for this gene, across all samples and sources.
The Sample column links to the cell line (cell-line samples) or the tissue type (tissue samples).
Use the Type / Source filters, the search box, and column sorting to explore; each CAN-IMMUNE ID opens the full mutation & peptide view.
| ID | Sample | Transcript | AA Change | CDS | Type | Source | Mutant Peptide | Wild-type Peptide |
|---|