Stats by Source
Total, split by cell line (COSMIC CL / DepMap / PubMed) vs tissue (COSMIC primary tissue)
Total = all mutations for this gene across every source.
Cell line = COSMIC Cell Lines Project + DepMap + PubMed.
Tissue = COSMIC primary-tissue (patient tumour) samples.
Total can exceed cell line + tissue: COSMIC tissue-derived models sit only in global, and a peptide can be shared across both.
| Total | Cell line | Tissue | |
|---|---|---|---|
| Mutations | 782 | 66 | 684 |
| Samples | 269 | 34 | 223 |
| Peptides | 202 | 26 | 174 |
Function
TMPRSS2 · Transmembrane serine protease 2
This gene encodes a protein that belongs to the serine protease family. The encoded protein contains a type II transmembrane domain, a receptor class A domain, a scavenger receptor cysteine-rich domain and a protease domain. Serine proteases are known to be involved in many physiological and pathological processes. This gene was demonstrated to be up-regulated by androgenic hormones in prostate cancer cells and down-regulated in androgen-independent prostate cancer tissue. The protease domain of this protein is thought to be cleaved and secreted into cell media after autocleavage. This protein also facilitates entry of viruses into host cells by proteolytically cleaving and activating viral envelope glycoproteins. Viruses found to use this protein for cell entry include Influenza virus and the human coronaviruses HCoV-229E, MERS-CoV, SARS-CoV and SARS-CoV-2 (COVID-19 virus). Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2020].
Isoforms & Proteins
3 transcripts · UniProt mapping is sequence-verified (AA-safe)
Each Ensembl transcript (ENST) this gene is mutated on, with its matched UniProt accession.
The mapping is sequence-verified: the UniProt sequence is identical to the transcript translation, so amino-acid positions line up exactly. A * marks an unreviewed (TrEMBL) entry.
Counts are mutations and unique mutant peptides on each transcript.
Gene Properties
Recurrent Mutations
All 186 amino-acid changes on canonical ENST00000332149 · needle height = samples · drag the mini-map to zoom
A lollipop / needle plot – the standard way to show recurrent mutations along a protein (as used by cBioPortal and MutationMapper).
X-axis = amino-acid position in the protein.
Needle height & head size = how often that exact amino-acid change was observed (its recurrence). Tall/large heads are mutational hotspots.
The most recurrent changes are labelled; hover any needle for the change, position and counts.
Mutation frequency across cancer types
% of samples with a missense/complex mutation in TMPRSS2 · cell line vs tissue
For each cancer type, the fraction of samples that carry at least one missense/complex mutation anywhere in TMPRSS2 – counted as distinct samples (a sample counts once no matter how many mutations it has).
Split into cell line and tissue; each cell shows mutated / total and the percentage. Cohorts with <20 samples are omitted. Ordered by combined frequency.
| Cancer type | Cell lines | Tissue samples |
|---|---|---|
| Gastrointestinal Stromal Tumour | 0/0 0% | 5/133 4% |
| Rhabdomyosarcoma | 0/33 0% | 7/171 4% |
| T-Lymphoblastic Leukemia | 1/40 2% | 0/0 0% |
| Endometrial Carcinoma | 2/42 5% | 13/612 2% |
| Other Solid Cancers | 2/94 2% | 18/1515 1% |
| Melanoma | 0/210 0% | 26/1899 1% |
| Bladder Carcinoma | 0/58 0% | 12/956 1% |
| Gastric Carcinoma | 2/74 3% | 19/1809 1% |
| Colorectal Carcinoma | 2/143 1% | 34/3239 1% |
| Glioblastoma | 1/98 1% | 0/0 0% |
| Cervical Carcinoma | 0/35 0% | 4/422 1% |
| Non-Cancerous | 0/104 0% | 7/830 1% |
| Small Cell Lung Carcinoma | 0/9 0% | 5/752 1% |
| Hepatocellular Carcinoma | 0/46 0% | 13/2210 1% |
| Thyroid Gland Carcinoma | 0/45 0% | 9/1592 1% |
| Esophageal Squamous Cell Carcinoma | 0/51 0% | 14/2550 1% |
| Osteosarcoma | 1/45 2% | 0/166 0% |
| Non-Small Cell Lung Carcinoma | 3/304 1% | 5/1390 0% |
| Prostate Carcinoma | 1/13 8% | 9/2105 0% |
| Ovarian Carcinoma | 1/109 1% | 4/998 0% |
| Neuroendocrine Tumour | 1/154 1% | 2/577 0% |
| Kidney Carcinoma | 1/85 1% | 5/1862 0% |
| Ewings Sarcoma | 1/63 2% | 0/262 0% |
| Biliary Tract Carcinoma | 1/54 2% | 2/950 0% |
| Head and Neck Carcinoma | 2/85 2% | 3/1574 0% |
| Glioma | 1/52 2% | 5/2127 0% |
| Other Sarcomas | 0/69 0% | 2/699 0% |
| Breast Carcinoma | 3/144 2% | 4/3264 0% |
| Neuroblastoma | 2/87 2% | 1/1331 0% |
| B-Lymphoblastic Leukemia | 4/55 7% | 1/2640 0% |
Mutation Distribution
Where TMPRSS2 is mutated · all tissues, split by cell line vs tissue
How many mutations in TMPRSS2 were found in each tissue, across the whole database.
Each bar is a tissue (cell-line and tissue names are merged to the standard tissue), split into cell line and tissue (patient tumour) contributions.
This shows the cancer-context where this gene is recurrently altered.
GTEx Expression
Median TPM across 54 healthy tissues
Median gene expression (TPM) in normal, non-cancer human tissues from the GTEx project.
Useful for judging tumour specificity – a strong neoantigen target ideally comes from a gene with low expression in healthy tissues.
Scroll or drag the mini-axis below the chart to browse all tissues.
Mutations
All 782 mutations in TMPRSS2
Every mutation record for this gene, across all samples and sources.
The Sample column links to the cell line (cell-line samples) or the tissue type (tissue samples).
Use the Type / Source filters, the search box, and column sorting to explore; each CAN-IMMUNE ID opens the full mutation & peptide view.
| ID | Sample | Transcript | AA Change | CDS | Type | Source | Mutant Peptide | Wild-type Peptide |
|---|