Stats by Source
Total, split by cell line (COSMIC CL / DepMap / PubMed) vs tissue (COSMIC primary tissue)
Total = all mutations for this gene across every source.
Cell line = COSMIC Cell Lines Project + DepMap + PubMed.
Tissue = COSMIC primary-tissue (patient tumour) samples.
Total can exceed cell line + tissue: COSMIC tissue-derived models sit only in global, and a peptide can be shared across both.
| Total | Cell line | Tissue | |
|---|---|---|---|
| Mutations | 227 | 54 | 171 |
| Samples | 226 | 54 | 170 |
| Peptides | 146 | 32 | 123 |
Function
TNFAIP6 · TNF alpha induced protein 6
The protein encoded by this gene is a secretory protein that contains a hyaluronan-binding domain, and thus is a member of the hyaluronan-binding protein family. The hyaluronan-binding domain is known to be involved in extracellular matrix stability and cell migration. This protein has been shown to form a stable complex with inter-alpha-inhibitor (I alpha I), and thus enhance the serine protease inhibitory activity of I alpha I, which is important in the protease network associated with inflammation. This gene can be induced by proinflammatory cytokines such as tumor necrosis factor alpha and interleukin-1. Enhanced levels of this protein are found in the synovial fluid of patients with osteoarthritis and rheumatoid arthritis.[provided by RefSeq, Dec 2010].
Isoforms & Proteins
1 transcript · UniProt mapping is sequence-verified (AA-safe)
Each Ensembl transcript (ENST) this gene is mutated on, with its matched UniProt accession.
The mapping is sequence-verified: the UniProt sequence is identical to the transcript translation, so amino-acid positions line up exactly. A * marks an unreviewed (TrEMBL) entry.
Counts are mutations and unique mutant peptides on each transcript.
| Transcript | UniProt | Mutations | Peptides |
|---|---|---|---|
| ENST00000243347 | P98066 | 227 | 146 |
Gene Properties
Recurrent Mutations
All 146 amino-acid changes on canonical ENST00000243347 · needle height = samples · drag the mini-map to zoom
A lollipop / needle plot – the standard way to show recurrent mutations along a protein (as used by cBioPortal and MutationMapper).
X-axis = amino-acid position in the protein.
Needle height & head size = how often that exact amino-acid change was observed (its recurrence). Tall/large heads are mutational hotspots.
The most recurrent changes are labelled; hover any needle for the change, position and counts.
Mutation frequency across cancer types
% of samples with a missense/complex mutation in TNFAIP6 · cell line vs tissue
For each cancer type, the fraction of samples that carry at least one missense/complex mutation anywhere in TNFAIP6 – counted as distinct samples (a sample counts once no matter how many mutations it has).
Split into cell line and tissue; each cell shows mutated / total and the percentage. Cohorts with <20 samples are omitted. Ordered by combined frequency.
| Cancer type | Cell lines | Tissue samples |
|---|---|---|
| T-Lymphoblastic Leukemia | 3/40 8% | 0/0 0% |
| Endometrial Carcinoma | 5/42 12% | 13/612 2% |
| Rhabdomyosarcoma | 0/33 0% | 4/171 2% |
| Non-Small Cell Lung Carcinoma | 7/304 2% | 19/1390 1% |
| Hodgkins Lymphoma | 2/16 12% | 0/122 0% |
| Melanoma | 6/210 3% | 20/1899 1% |
| Colorectal Carcinoma | 5/143 4% | 33/3239 1% |
| Glioblastoma | 1/98 1% | 0/0 0% |
| Bladder Carcinoma | 0/58 0% | 10/956 1% |
| Neuroendocrine Tumour | 6/154 4% | 0/577 0% |
| Squamous Cell Lung Carcinoma | 3/57 5% | 4/810 0% |
| Gastrointestinal Stromal Tumour | 0/0 0% | 1/133 1% |
| Cervical Carcinoma | 0/35 0% | 3/422 1% |
| Non-Cancerous | 0/104 0% | 6/830 1% |
| Head and Neck Carcinoma | 2/85 2% | 7/1574 0% |
| Small Cell Lung Carcinoma | 0/9 0% | 4/752 1% |
| Esophageal Carcinoma | 0/23 0% | 3/769 0% |
| Gastric Carcinoma | 0/74 0% | 7/1809 0% |
| Hepatocellular Carcinoma | 4/46 9% | 3/2210 0% |
| Biliary Tract Carcinoma | 1/54 2% | 2/950 0% |
| Glioma | 0/52 0% | 6/2127 0% |
| Ovarian Carcinoma | 2/109 2% | 1/998 0% |
| Other Solid Cancers | 0/94 0% | 4/1515 0% |
| Prostate Carcinoma | 1/13 8% | 4/2105 0% |
| Breast Carcinoma | 0/144 0% | 8/3264 0% |
| Pancreatic Carcinoma | 0/89 0% | 3/1611 0% |
| Thyroid Gland Carcinoma | 1/45 2% | 2/1592 0% |
| Kidney Carcinoma | 0/85 0% | 3/1862 0% |
| Esophageal Squamous Cell Carcinoma | 3/51 6% | 0/2550 0% |
| B-Cell Non-Hodgkins Lymphoma | 2/88 2% | 1/2534 0% |
Mutation Distribution
Where TNFAIP6 is mutated · all tissues, split by cell line vs tissue
How many mutations in TNFAIP6 were found in each tissue, across the whole database.
Each bar is a tissue (cell-line and tissue names are merged to the standard tissue), split into cell line and tissue (patient tumour) contributions.
This shows the cancer-context where this gene is recurrently altered.
GTEx Expression
Median TPM across 54 healthy tissues
Median gene expression (TPM) in normal, non-cancer human tissues from the GTEx project.
Useful for judging tumour specificity – a strong neoantigen target ideally comes from a gene with low expression in healthy tissues.
Scroll or drag the mini-axis below the chart to browse all tissues.
Mutations
All 227 mutations in TNFAIP6
Every mutation record for this gene, across all samples and sources.
The Sample column links to the cell line (cell-line samples) or the tissue type (tissue samples).
Use the Type / Source filters, the search box, and column sorting to explore; each CAN-IMMUNE ID opens the full mutation & peptide view.
| ID | Sample | Transcript | AA Change | CDS | Type | Source | Mutant Peptide | Wild-type Peptide |
|---|