Stats by Source
Total, split by cell line (COSMIC CL / DepMap / PubMed) vs tissue (COSMIC primary tissue)
Total = all mutations for this gene across every source.
Cell line = COSMIC Cell Lines Project + DepMap + PubMed.
Tissue = COSMIC primary-tissue (patient tumour) samples.
Total can exceed cell line + tissue: COSMIC tissue-derived models sit only in global, and a peptide can be shared across both.
| Total | Cell line | Tissue | |
|---|---|---|---|
| Mutations | 116 | 23 | 91 |
| Samples | 113 | 23 | 88 |
| Peptides | 93 | 18 | 78 |
Function
TNFRSF4 · TNF receptor superfamily member 4
The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor has been shown to activate NF-kappaB through its interaction with adaptor proteins TRAF2 and TRAF5. Knockout studies in mice suggested that this receptor promotes the expression of apoptosis inhibitors BCL2 and BCL2lL1/BCL2-XL, and thus suppresses apoptosis. The knockout studies also suggested the roles of this receptor in CD4+ T cell response, as well as in T cell-dependent B cell proliferation and differentiation. [provided by RefSeq, Jul 2008].
Isoforms & Proteins
1 transcript · UniProt mapping is sequence-verified (AA-safe)
Each Ensembl transcript (ENST) this gene is mutated on, with its matched UniProt accession.
The mapping is sequence-verified: the UniProt sequence is identical to the transcript translation, so amino-acid positions line up exactly. A * marks an unreviewed (TrEMBL) entry.
Counts are mutations and unique mutant peptides on each transcript.
| Transcript | UniProt | Mutations | Peptides |
|---|---|---|---|
| ENST00000379236 | P43489 | 116 | 93 |
Gene Properties
Recurrent Mutations
All 93 amino-acid changes on canonical ENST00000379236 · needle height = samples · drag the mini-map to zoom
A lollipop / needle plot – the standard way to show recurrent mutations along a protein (as used by cBioPortal and MutationMapper).
X-axis = amino-acid position in the protein.
Needle height & head size = how often that exact amino-acid change was observed (its recurrence). Tall/large heads are mutational hotspots.
The most recurrent changes are labelled; hover any needle for the change, position and counts.
Mutation frequency across cancer types
% of samples with a missense/complex mutation in TNFRSF4 · cell line vs tissue
For each cancer type, the fraction of samples that carry at least one missense/complex mutation anywhere in TNFRSF4 – counted as distinct samples (a sample counts once no matter how many mutations it has).
Split into cell line and tissue; each cell shows mutated / total and the percentage. Cohorts with <20 samples are omitted. Ordered by combined frequency.
| Cancer type | Cell lines | Tissue samples |
|---|---|---|
| Chronic Myelogenous Leukemia | 2/25 8% | 0/0 0% |
| Acute Myeloid Leukemia | 3/90 3% | 0/0 0% |
| Oral Cavity Carcinoma | 1/54 2% | 0/0 0% |
| Melanoma | 1/210 0% | 15/1899 1% |
| Endometrial Carcinoma | 3/42 7% | 2/612 0% |
| Biliary Tract Carcinoma | 0/54 0% | 5/950 1% |
| Other Solid Cancers | 1/94 1% | 7/1515 0% |
| Neuroendocrine Tumour | 2/154 1% | 1/577 0% |
| Non-Small Cell Lung Carcinoma | 1/304 0% | 6/1390 0% |
| Colorectal Carcinoma | 0/143 0% | 12/3239 0% |
| Squamous Cell Lung Carcinoma | 0/57 0% | 3/810 0% |
| Gastric Carcinoma | 1/74 1% | 5/1809 0% |
| Ewings Sarcoma | 1/63 2% | 0/262 0% |
| Thyroid Gland Carcinoma | 0/45 0% | 5/1592 0% |
| Bladder Carcinoma | 0/58 0% | 3/956 0% |
| Kidney Carcinoma | 2/85 2% | 3/1862 0% |
| Cervical Carcinoma | 0/35 0% | 1/422 0% |
| Hepatocellular Carcinoma | 0/46 0% | 5/2210 0% |
| Prostate Carcinoma | 0/13 0% | 4/2105 0% |
| Ovarian Carcinoma | 1/109 1% | 1/998 0% |
| Glioma | 1/52 2% | 2/2127 0% |
| Esophageal Carcinoma | 0/23 0% | 1/769 0% |
| Small Cell Lung Carcinoma | 0/9 0% | 1/752 0% |
| Other Sarcomas | 1/69 1% | 0/699 0% |
| Esophageal Squamous Cell Carcinoma | 0/51 0% | 3/2550 0% |
| Head and Neck Carcinoma | 0/85 0% | 2/1574 0% |
| B-Cell Non-Hodgkins Lymphoma | 1/88 1% | 1/2534 0% |
| Pancreatic Carcinoma | 0/89 0% | 1/1611 0% |
| B-Lymphoblastic Leukemia | 0/55 0% | 1/2640 0% |
| Breast Carcinoma | 1/144 1% | 0/3264 0% |
Mutation Distribution
Where TNFRSF4 is mutated · all tissues, split by cell line vs tissue
How many mutations in TNFRSF4 were found in each tissue, across the whole database.
Each bar is a tissue (cell-line and tissue names are merged to the standard tissue), split into cell line and tissue (patient tumour) contributions.
This shows the cancer-context where this gene is recurrently altered.
GTEx Expression
Median TPM across 54 healthy tissues
Median gene expression (TPM) in normal, non-cancer human tissues from the GTEx project.
Useful for judging tumour specificity – a strong neoantigen target ideally comes from a gene with low expression in healthy tissues.
Scroll or drag the mini-axis below the chart to browse all tissues.
Mutations
All 116 mutations in TNFRSF4
Every mutation record for this gene, across all samples and sources.
The Sample column links to the cell line (cell-line samples) or the tissue type (tissue samples).
Use the Type / Source filters, the search box, and column sorting to explore; each CAN-IMMUNE ID opens the full mutation & peptide view.
| ID | Sample | Transcript | AA Change | CDS | Type | Source | Mutant Peptide | Wild-type Peptide |
|---|